Evidence-based Treatment of Psychotic Depression

Evidence-based Treatment of Psychotic Depression
By:Gregory W. Dalack, MD

The Practice of EBM

Step 1: Asking an answerable question
Step 2: Tracking down the best evidence to answer that question
Step 3: Critically appraise the evidence for validity, size of the effect, and utility of the findings
Step 4: Incorporate the clinical appraisal into our clinical expertise and patient’s individual issues
Step 5: Evaluate and improve steps 1-4 with each new opportunity to apply these principles


Brief case history
Asking answerable clinical questions (CEBM- Oxford)
An answerable clinical question

For patients with psychotic depression...
...is antidepressant treatment alone...
...when compared to antidepressant plus antipsychotic treatment…
...result in greater improvement of depressive/psychotic symptoms?

Search Treatment of Psychotic Depression

Electronic Books
Classic Study
The pharmacological treatment of delusional depression
Search Treatment of Psychotic Depression
Relative Risk: the ratio in the treated group to the risk in the control group (TG/CG)
Conclusions

Evidence-based Treatment of Psychotic Depression.ppt