Showing posts with label Interdisciplinary. Show all posts
Showing posts with label Interdisciplinary. Show all posts

29 November 2014

Bleeding disorders Ppts and latest 200 publications



Bleeding Disorders an Overview With Emphasis on Emergencies
http://www.med.wayne.edu/

Acquired Bleeding Disorders
Steven Pipe, MD
http://open.umich.edu/

Disorders of Primary Hemostasis
http://instructional1.calstatela.edu/

Laboratory Diagnosis of Bleeding Disorders
http://www.columbia.edu

Oral Manifestations of Systemic Diseases
http://www.cabrillo.edu

Bleeding & Clotting Disorders I
Richard E. Freeman MD
http://paportal.lhup.edu

Pediatric Hematology
R. Hadley, PhD
http://www.uky.edu

Causes of Bleeding
http://williams.medicine.wisc.edu/

Hemorrhage, Hemostasis and Circulatory Shock
https://www.life.illinois.edu

Complications of Pregnancy
http://www.austincc.edu

Hemostasis & Thrombosis
Beth A. Bouchard
http://biochem.uvm.edu

Third Trimester Bleeding, Postpartum Hemorrhage, & Shock Management
https://www.med.unc.edu

Gastrointestinal Bleeding 
David A. Gremse, MD,
http://medicine.nevada.edu/

Clotting of Blood
https://files.nyu.edu

Perioperative Medical Care of the Surgical Patient
Darrell L. Hunt, MD
http://education.surgery.ufl.edu 

Latest 200 Published articles on bleeding disorders

20 April 2013

Medicine Grand Rounds Video from nyu.edu 2012-13






Date:
Sponsoring Division/Unit:
 Presenter:
Title of Presentation:
3/12/2013
Department Research
3/5/2013
Endocrinology
2/26/2013
Pulmonary, Critical Care,
and Sleep Medicine
2/19/2013
Translational Medicine
2/12/2013
Infectious Diseases and Immunology
2/5/2013
General Internal Medicine
1/29/2013
Gastroenterology
1/22/2013
Medical Humanities
1/15/2013
Pulmonary, Critical Care
and Sleep Medicine
1/8/2013
Nephrology
12/18/2012
General Internal Medicine
10/11/2012
Endocrinology
10/16/2012
Hematology and Medical Oncology
10/09/2012
Rheumatology
10/02/2012
Hematology and Medical Oncology
09/18/2012
Nephrology
09/11/2012
Cardiology
09/04/2012
General Internal Medicine

02 February 2013

POEMS Syndrome



POEMS Syndrome [Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes] also known as Crow–Fukase syndrome.

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or a growth factor.[Mediscape]

Castle-POES disease successfully treated with Rituximab
Nezam Torok , MD
http://www.utoledo.edu

Progressive Ascending Paralysis in an Adult Male diagnosed with POEMS Syndrome:
A Case Report
http://www.temple.edu

Castleman’s Disease
Anastassia Doutova
http://www.med.unc.edu

Scleromyxedema
Christine Williams, MD
https://medicine.med.unc.edu 20Scleromyxedema.ppt

Dermal and Subcutaneous Tumors
Erik Austin, D.O., M.P.H.
http://www.atsu.edu

Diseases of the Skin Appendages
http://www.atsu.edu

Genodermatosis
Boris Ioffe, D.O.
http://www.atsu.edu

Type 1A Diabetes Immunology and Polyglandular Syndromes
http://som.ucdenver.edu

Multiple Myeloma
Pamela S. Becker, MD, PhD
http://blog.hsl.washington.edu/ 

29 September 2012

MAPK Inhibitors




Novel Prevention and Treatment Approaches to Cancer
Cemile Kumas
http://faculty.smu.edu/

Vemurafenib: mechanisms of resistance and secondary skin tumors
Eric Knoche
http://hematology.wustl.edu

Extinction of auditory fear conditioning requires MAPK/ERK activation in the basolateral amygdala
Herry et al
http://people.usd.edu

A MAPK cascade in Arabidopsis innate immunity
Guillaume Tena
http://molbio.mgh.harvard.edu

Primary Pulmonary Hypertension: Recent Insights into Molecular Pathways Underlying Pathogenesis
Jonathan Alexander MD PhD
http://pulmonary.ucsf.edu

Drug Design Kinase Regulation and targeting
http://www.pharmacy.umaryland.edu

Protein kinases : Role in cell signaling & implication in human pathologies
Jayanti Tokas, Rubina Begum, Shalini Jain and Hariom Yadav
http://www.pitt.edu

Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory
Raymond J. Kelleher III, Arvind Govindarajan, Hae-Yoon Jung, Hyejin Kang and Susumu Tonegawa
http://classes.biology.ucsd.edu

Chemopreventive Phytochemicals
http://www.integratedhealthcare.eu

A Road-Map to Integrated Biomarker Studies
George R. Simon, MD
http://hcc.musc.edu

Dose Escalation of Topical Curcumin
Christopher D. Lao, MD, MPH
http://www.cancer.med.umich.edu

How Organs are Stored Today
Charles Chiang, Kathy Jee, Diana Zhong
http://teams.gemstone.umd.edu

MAP Kinase family regulates the nuclear localization of Nrf2
Ngan Nguyen, Tory Hagen
http://oregonstate.edu

Signaling by Serine/Threonine Kinase Receptors
http://www.calstatela.edu

Map Kinase (Map = mitogen-activated protein kinases)
http://clasfaculty.ucdenver.edu

Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis
Yan Shi, Ravi P Sahu and Sanjay K Srivastava
http://www.chem.wwu.edu

Cell cycle and differentiation
http://www.ap.gatech.edu

Signal Transduction
http://mcb.berkeley.edu

38 Published articles on MAPK Inhibitors

23 September 2012

Granulomatous




Case Studies: Granulomatous Inflammation
Demaretta Rush, M.D.
https://www.pathology.ufl.edu

Chronic Granulomatous Disease (CGD)
http://www.uhmc.sunysb.edu

Subacute (de Quervain’s) Thyroiditis
Lauren Galpin, MD
http://www.med.unc.edu

Wegener’s Granulomatosis
Kristine Scruggs
https://medicine.med.unc.edu

52nd Annual Diagnostic Slide Session 2011
Cristiane M. Ida, M.D., Caterina Giannini, M.D. Ph.D., Julie E. Hammack, M.D., Jonathan M. Morris, M.D.
http://neuro.pathology.pitt.edu

Case Study
Kenneth Clark, MD
http://neuro.pathology.pitt.edu

Granulomatous Lymphocytes and Macrophages Space occupying lesion
http://www.uth.tmc.edu

Case Report
Phillip Parmet, M.D.
http://www.uth.tmc.edu


Primary Vasculitides
Amy Shultz, M.D.
http://imrp.ouhsc.edu

Case Study -
Trinidad Cisneros, Ruby Khan, Patricia Nykaza
http://instructional1.calstatela.edu/

Sarcoidosis
T. Lianne Beck, MD
http://www.fpm.emory.edu

Review of Elevated Lesions of the Retina
Kimberly D Kohne, OD, FAAO
http://www.opt.indiana.edu

Clinical Pathology Conference
Stanford Massie M.D.
http://www.uab.edu

Vasculitis II
William Clapp, M.D.
https://www.pathology.ufl.edu

Type 4 Hypersensitivity and Autoimmunity 
Chang Kim
http://web.ics.purdue.edu
600 free full text published articles

27 August 2012

Retinoids



Aging skin & Vitamin A (retinoids)
http://mcb.berkeley.edu

Influence of Retinoids on Embryonic Chick Intestinal Development
J. Orion Rogers and Sheila Shomo
http://www.radford.edu

Vitamin A
https://camcom.ngu.edu

Acne: Evaluation and Management
Betsy Pfeffer MD
http://www.columbia.edu

Vitamins and minerals
http://www.csuchico.edu

Recurrent Respiratory Papillomatosis
Michael E. Decherd, MD, Ronald W. Deskin, MD
http://www2.utmb.edu

The Synthetic Retinoid
Arsen Khachatryan
http://ww2.biol.sc.edu

Fat-Soluble Vitamins
http://35-206-202.wiki.uml.edu

Acne Treatment and Therapeutic Strategies
Dr. Marie Andrades
http://www.pitt.edu

Psoriasis
Mark Gill, PharmD, Professor of Clinical Pharmacy
http://www-hsc.usc.edu

Nuclear Receptors and Cancer
Joe Lipsick
http://www.stanford.edu

462 Published articles on Retinoids

09 May 2012

Thoracic Outlet Compression Syndrome



Thoracic Outlet Syndrome
Tim Kubal
Thoracic Outlet Syndrome.ppt

An Interesting Case of Thoracic Outlet Syndrome
Laurel Romer, M.D.
An Interesting Case of Thoracic Outlet Syndrome.ppt

Procedures
Procedures.ppt

Sholder Complex
Shoulder.ppt

Work Related Musculoskeletal Disorders
Work Related Musculoskeletal Disorders.ppt

The Shoulder Complex
The Shoulder Complex.ppt

Shoulder Evaluation
Shoulder Evaluation.ppt

Ergonomics Evaluations
Ergonomics Evaluations.ppt

Postural Evaluation
Postural Evaluation.ppt

Care of the Vascular Patient
Stacey Becker, RN, Angela Allen, ACNP
Care of the Vascular Patient.ppt

Shoulder Injuries
shoulder_evaluation.ppt

CERVICAL HYPOLORDOSIS: A CASE STUDY OF TREATMENTS AND OUTCOMES
EMILY ZIPOY, MATHEW KALAPURAYIL, RHONDA CROSS BEEMER
CERVICAL HYPOLORDOSIS.ppt?sequence=1
71 free full text articles links

06 April 2012

Paraneoplastic Syndrome Ppts and 48 full text articles



Paraneoplastic Syndrome
Shirley H. Wray, M.D., Ph.D., FRCP
Saccades_guest_lecture.ppt

SIADH
Sandy Kelly MSN, RN-BC,OCN
SIADH.ppt

Common Cutaneous Manifestations Resulting From Paraneoplastic Internal Disease
Presented  by Brian M. Swan, M.D.
Swan.ppt

Tumor  Host Interactions
Husni Maqboul,  M.D
Tumor  Host Interactions.ppt

Pediatric Oncology  for Otolaryngologists
Frederick S.  Huang, M.D.
Pediatric Oncology  for Otolaryngologists.ppt

Case Study
Alex  Ulitsky, MD, Walter  Hogan, MD
Bloatingcase.ppt

Case  Presentation
Leslie  Andritsos, M.D.
Case  Presentation.ppt

Collagen Vascular Diseases
Collagen Vascular Diseases.ppt

30 March 2012

Atrophy



Atrophy is the partial or complete wasting away of a part of the body. A wasting or decrease in the size of an organ or tissue.

Spinal Muscular Atrophy (SMA) in the Puerto
Aníbal Cruz Sánchez, Sonia Muñoz García, Cristina Rivera Febres
Spinal Muscular Atrophy.ppt

MicroRNA Target Prediction Using Muscle Atrophy Genes As Models
Caltech Wold Lab
Muscle Atrophy Genes As Models .ppt

Spinal Muscular Atrophy (SMA)
Nanci Yuan, MD
sma.ppt

Imaging Degenerative Diseases of the Brain
Cathleen Kouvolo
Imaging Degenerative Diseases of the Brain.ppt

Atrophy
Anna Eichner, Sam Laskey, Diana Thomas, Baron Kim
ATROPHY.ppt

Neuroimaging Data Provenance Using the LONI Pipeline Workflow Environment
Allan MacKenzie-Graham, Arash Payan, Ivo Dinov, John Van Horn, Arthur W. Toga
Neuroimaging Data.ppt

Motor Neuron Disease
MOTOR_NEURON_DISEASE.ppt

Atrophic Rhinitis
Alan L. Cowan, M.D., Matthew Ryan, M.D.
Atrophic-Rhinitis.ppt

Hepatic Artery Disorders



Hepatic Artery Disorders
Also known as: Hepatic Artery Occlusion; Hepatic Artery Thrombosis; Hepatic Artery Aneurysm; Liver Artery Occlusion; Liver Artery Thrombosis; Liver Artery Aneurysm.

Hepatobiliary Disorders
Hepatobiliarydisorders.ppt

Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Syndrome)
Andrew Avery
Hereditary Hemorrhagic Telangiectasia.ppt

The Liver
The Liver.ppt

Assessment and Management of Patients With Hepatic Disorders
Miss Iman Shaweesh
Hepatic Disorders.ppt

Hepatic Disorders: Hepatitis/Cirrhosis
Lisa Randall
Hepatic_Disorders_000.ppt

Medical and Surgical Approach to Biliary and Gallbladder Disease
Norman H. Gilinsky, M.D., FACP, FACG
GallBladd.ppt

Managing Hepatic Disorders
Hepatic Disorders.ppt

Liver Functions
CholestaticLiverDiseasejaundicewithCholangiocarcinomafocus.ppt

End Stage Liver Disease in HIV Patients
HepaticFailure.ppt

Assessment and Management of Patients With Hepatic Disorders
Hepatic DisordersPart2.ppt

Liver Disorders
John Nation
Liver Disorders.ppt

05 March 2012

Diagnostic Tests




A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease.

Evaluation of  Diagnostic Tests
Gary E Raskob,  Ph. D.
http://gcrc.ouhsc.edu/documents/Evaluationofdiagnostictests.ppt

Diagnostic Tests 
Shurouq  Qadose
http://elearning.najah.edu/OldData/pdfs/diagnostic%20test.ppt

Critical  Appraisal of Articles  About Diagnostic Tests
Rani  Gereige, M.D., MPH
http://health.usf.edu/NR/rdonlyres/B263F946-AC48-4E3B-B634-DD95C6C33AA6/29656/CriticalAppraisalofArticlesAboutDiagnosticTests.ppt

Methods  for Evaluating the Performance of Diagnostic  Tests in the Absence of a “Gold Standard:” A Latent Class Model Approach
Elizabeth  Garrett-Mayer, Division  of Biostatistics
http://people.musc.edu/~elg26/talks/carmatalk.ppt

Bayesian  modeling of the accuracy  of diagnostic tests
Adam  Branscum, U.C. Davis, Wes  Johnson, Ian  Gardner
http://www.epi.ucdavis.edu/diagnostictests/files/Bayes-TestAccTalk.ppt

Diagnostic Tests  and Full-Response Fault Dictionary
Vishwani D.  Agrawal
http://www.eng.auburn.edu/~agrawvd/COURSE/E7950_Fall09/TALK/Oct28_Agrawal_Diagnosis.ppt

Diagnostic  Tests for Lower Extremity  Osteomyelitis
Laura  Zakowski, MD
http://www2.medicine.wisc.edu/home/files/domfiles/genintmed/3-12-08-Zakowski-Osteomyelitis%20diagnosis%20PCC.ppt

Comparing the Use of Diagnostic Tests in Canadian and US Hospitals
Steven J Katz, Laurence F McMahon and Willard G Manning
http://www.econ.wayne.edu/agoodman/7550/week14/CANADA_US.ppt

Basic Research Designs An Overview
Frances S. Shofer, PhD
http://www.uphs.upenn.edu/em/Research/academicassociates/ppt/study_designs.ppt

Diagnostic  Tests
http://web.as.uky.edu/statistics/users/viele/sta570s07/diagnostictests.ppt

PDF Lecture Notes Here

05 February 2012

Primary amyloidosis Ppts latest 50 Published articles



Primary amyloidosis: Primary amyloidosis is a disorder in which abnormal proteins build up in tissues and organs. Clumps of the abnormal proteins are called amyloid deposits.

Primary amyloidosis can lead to conditions that include:
    Carpal tunnel syndrome
    Heart muscle damage (cardiomyopathy) leading to congestive heart failure
    Intestinal malabsorption
    Liver enlargement
    Kidney failure
    Nephrotic syndrome
    Neuropathy (nerves that do not work properly)
    Orthostatic hypotension (abnormal drop in blood pressure with standing)

Primary  AL Amyloidosis
by Matthew  Volk
http://www.med.unc.edu/medicine/web/12.1.08%20Volk.%20Amyloid,%20LCDD.ppt

Cardiac  Amyloidosis
by Ann Isaksen
https://medicine.med.unc.edu/education/internal-medicine-residency-program/files/ppt/11.10.09%20Isaksen%20cardiac%20amyloid.ppt

Primary  Amyloidosis  Case Presentation & Discussion
By Warren  Brenner
http://hematology.wustl.edu/conferences/presentations/Brenner20031017.ppt

Immune Disorders:  HLA and Disease Associations and Amyloidosis
by Nancy L. Jones, M.D.
http://cmspath.edu/rfc/lectures11-12/jones/hla/jones-hla_and_amyloidosis.ppt

Protein  Structure Determination, Protein Folding, Molecular Chaperones, Prions Alzyheimer’s
http://www.uh.edu/sibs/faculty/glegge/lecture_18.ppt

Computational  Method for Predicting Amyloidogenic Sequences
by Bill Welsh
http://dimacs.rutgers.edu/Workshops/Neurodegenerative/slides/welsh.ppt

Alphabet  Soup and Interstitial Lung Disease
by Leslie  Scheunemann
http://www.med.unc.edu/medicine/web/3.26.08%20ILD%20Scheunemann.ppt

Latest 50 Published articles:

17 January 2010

Pediatric Urology- Gynecology



Pediatric Urology- Gynecology
By:Keith Wilkinson, MD FACEP

Anatomy
Shaft
Corpus Cavernosum (two)
* Two large columns on penile dorsum
* Columns separated by septum of fibers
Corpus spongiosum
* Located on ventral side (underside) of penis
* Does not contribute to penile rigidity
* Contains urethra
Tunica albuginea
* Bands together the two columns of corpus cavernosa
Lacunar space (Space of Smith)
* Surrounds tunica albuginea
* Intralacunar smooth muscle found within space

Anatomy
Glans
Innervation-
Sensation-
Pudendal nerve supplies dorsal nerves to penis
Erectile function- Nerves course through corpus cavernosa
Parasympathetic input (excitatory)- “Point”
Nervi erigentes runs adjacent to prostate gland
Sympathetic input (inhibitory)- “Shoot”
Sympathetic nerves supplied by thoracolumbar plexus
Vascular Supply of the Penis
Arterial inflow
Branches of deep internal pudendeal arteries

Hypospadias
* Incomplete development of the anterior urethra
o Anterior- (50 %)- Distal 1/3rd ventral shaft
o Middle- (20 %) percent of cases)- Middle 1/3rd
o Posterior hypospadias (30%)- Proximal 1/3rd
* More common in caucasians (esp Italians, Jews)
* Hypospadias, chordee associated with undescended testes and inguinal hernia (9- 17%)
o Abnormalities of the higher urinary tract are infrequent
* Treatment
o Single stage repair at age 6-18 months

Phimosis
* Previously retractable foreskin no longer retractable or foreskin retraction doesn’t occur by puberty
* Most retract by 1 year with 80% by age 4
* Rare in children
* Circumcision, repeated trauma, infections, poor hygiene, or chemical irritation
* Kids more likely to have obstruction
o Adults present with pain
* Surgery for obstruction of urinary stream, recurrent UTI or bouts of balanoposthitis

Phimosis
* Treatment
o Rare- only required for retention, possible prepuce abscess
o Urinary retention
+ Tub urination
+ Place feeding tube
+ Suprapubic aspiration safe, temporary
o Dorsal slit
+ Dorsal block or collar block
+ Double hemostat crush swollen prepuce
+ Incise between hemostats
+ Close open ends with absorbable suture
* Inability to extend foreskin back over glans
* Less common than phimosis
* Much more common in adults than kids
* More pressing than phimosis
* Often iatrogenic
* Therapy
o Pain management-
+ Topical 2% lidocaine gel or EMLA (eutectic mixture of local anesthetics cream [2.5% prilocaine, 2.5% lidocaine]
+ Systemic analgesia, dorsal penile nerve block, ring block
+ 1-5 cc lidocaine without epi
# 1/2 at 10:00 and 2:00 position at shaft base
# Inject between Buck’s fascia and corpora
o Control of edema-
+ Granular sugar to the surface of the swollen foreskin, cover with a condom or a finger of a rubber glove
+ Cool, compressive 1-in Surgical Cling dressings wrapped distal to proximal
+ Cooled with ice water-filled latex examination gloves
* Therapy
o Direct circumferential manual compression
o Hyaluronidase
+ 1 mL of hyaluronidase (150 U/cc Wydase) injected via TB syringe directly into several sites of the edematous foreskin
+ Breaks down hyaluronic acid in connective tissue, enhances fluid diffusion between tissue planes
+ Almost immediate decreased swelling
o Manual reduction
+ Distal traction of the foreskin using index and third fingers
+ Thumbs push the glans penis back through the paraphimotic ring of the foreskin
o Dorsal slit

Balanitis
Inflammation of the glans
* More common in men than boys
* Causes

Uncircumcised, poor hygiene
Chemical irritants (soap, petroleum jelly)
Drug allergies (tetracycline, sulfonamide)
Morbid obesity
Candidal species
Group A and B streptococci, Staph.,
Trichomonal species
Herpes Simplex
* Recurrent bouts can lead to phimosis

Balanitis
* Testing
o Serum glucose
o Culture of discharge
o Wet mount for Candida
o Syphilis serology test if STD suspected
o Herpes PCR swab
o Gonorrheal, chlamydia in adolescent, suspicion of abuse
* Treatment
o Retract the foreskin daily and soak in warm water to clean penis and foreskin
o Apply Bacitracin (not Neosporin)
o Apply topical clotrimazole for probable candidal balanitis

Balanoposthitis
* Inflammation of the glans and foreskin
* Etiology- uncircumcised, usually preschoolers
o Infection-
+ Grp A Strep (thin, purulent discharge; rapid strep positive), Staph, Candida, rarely gram negatives, syphilis (adolescents)
o Chronic friction, zipper injuries, and contact dermatitis, or a fixed drug eruption (TCN, or clotrimazole)
o Chronic- Balanitis xerotica obliterans
* Treatment-
o Local hygiene (sitz baths, cleaning)
o 0.5% hydrocortisone cream to the affected parts
o Antimicrobial topical ointments
+ Utility is unproved
o Oral antibiotics
+ 5 to 7 days of amoxicillin or cephalexin in recalcitrant cases or with more advanced cellulitis
+ Recurrence raises suspicion of DM, immunocompromise, Balanitis xerotica obliterans

Pearly Papules
* Common- seen in 30%
o Most common in young, uncircumcised African- Americans
* Empty hair follicules on the corona
* Benign- Do not warrant treatment
o Don’t resolve with circumcision
* Can be confused with (genital warts)

Meatal Stenosis
* Circumcised males
* Follows inflammatory reaction around meatus
o Usually diaper rash
* Significant when sprays or dorsally deflects stream
* Obstruction, dysuria, UTI uncommon
o Tub voids, urologic consultation
o Foley catheter, urethral meatotomy
Priapism
* Can occur in any age group
o Peaks at age 5-10 years, 20-50 years
* Causes
o Erectile dysfunction drugs most common causes of adult priapism (0.05-6% of users)
o Sickle cell most common cause in children
+ Causes 2/3rd of all cases
+ Occurs in 27% male children, 89% male adults
+ Highest aged 19-21 years
* Duration of symptoms most important factor affecting outcome
o Up to 92% with priapism for less than 24 hours remained potent
o Only 22% with priapism that lasted longer than 7 days remained potent
* Erection-smooth muscle relaxation and increased arterial flow into the corpora cavernosa
o Engorgement of the corpora cavernosa causes compression of the venous outflow tracts (ie, subtunical venules), resulting in blood trapping within the corpora cavernosa.
o Nitric oxide- major neurotransmitter controlling erection
+ Corpora cavernosa endothelium lining secretes nitric oxide

* Priaprism - failure of detumescence
+ Underregulation of arterial inflow (ie, high flow)
+ Failure of venous outflow (ie, low flow)- more common
# Excessive release of neurotransmitters
# Blockage of draining venules (eg, mechanical interference in sickle cell crisis, leukemia, or excessive use of IV TPN
* Treatment
o Impotence uncommon
o Need for surgical decompression uncommon
o Most low- flow, resolves spontaneously
o Hydration, analgesia
* Sickle cell disease
o Analgesics, hydration
o Exchange transfusion
+ Aim for reduction of Hgb S to 30- 35%
+ Aim for HCT > 30%
o Medical therapy successful up to 37%Alpha, beta agonists
o Oral pseudoephedrine or oral beta-agonists- (terbutaline) little efficacy
* Penile nerve block
o Bupivicaine without epi
* Intercavernosal phenylephrine (Neo-Synephrine)- drug of choice
o Nearly pure alpha agonist
o Intracavernosal injection
o 1 mL:1000 mcg diluted with an additional 9 mL NS
o Inject 0.3-0.5 ml using a 29-gauge needle into the corpora cavernosa
o Compress area of injection
o Wait 10-15 minutes between injections

Penile decompression
* Repeated aspirations or irrigations and sympathomimetic injections over several hours might be necessary
* Resolution of ischemic priapism following sympathomimetic injection with or without irrigation has been shown to occur in 43-81%
* Aspiration- 16- to 18-gauge angiocath into the lateral aspect of the corpus cavernosum
o Unilateral approach usually adequate because of the vascular channels between the 2 corpora cavernosa
o May be difficult because of the sludging of blood within the corpus cavernosum
o Saline irrigation and repeated aspirations may improve flow dynamics
* Surgical decompression
* Phenylephrine irrigation
o 1000 mcg phenylephrine in 100 mL of normal saline (10 mcg/mL)
o Infuse 10-20 mL at a time
o If unable to infuse, inject phenylephrine directly in 200- to 500-mcg aliquots
o Maximum dose of 1500 mcg
o Compression must be applied
o Epinephrine can also be used

Penile Trauma
* Zipper injury
o Local anesthetic
o Cute median bar with wire cutters
* Corporal rupture
o Adolescents, teens, adults
o Palpable, audible snap
o Acute bending of the penis
o Acute pain, immediate detumescence
o Delayed presentation common
o Treatment
+ Exploration
* Shaft laceration
o Exclude corporal, uretheral injuries
o Close with absorbable suture
* Toilet seat most common
o Corporal, urethral injury uncommon
o Meatal blood warrants consultation, consideration for retrograde urethrogram

Scrotal Pain by Age
* Acute scrotal pain seen in the ED
o Torsion of an appendage was the most common diagnosis (46%)
+ Especially age 3- 13
o Epididymitis next (35%)
+ Most common after age 13
o Testicular torsion (16%)
+ Most common cause in first year (86%)

Testicular Torsion

Read more...

10 July 2009

Before and after fistula repair



Before and after fistula repair

Tracheoesohpageal fistula

An omphalocele is an abdominal wall defect at the base of the umbilical cord (umbilicus); the infant is born with sac protruding through the defect which contains small intestine, liver, and large intestine.

Gastroschisis:
Surgical repair of abdominal wall defects involves replacing the abdominal organs back into the abdomen through the abdominal wall defect, repairing the defect if possible, or creating a sterile pouch to protect the intestines while they are gradually pushed back into the abdomen.

Anorectal malformations; Anal atresia
Imperforate anus is a relatively common congenital malformation that occurs in about 1 out of 5,000 infants.
signs & symptoms
o absence of anal opening
o misplaced anal opening
o anal opening very near the vaginal opening in the female
o no passage of first stool within 24 to 48 hours after birth
o stool passed by way of vagina or urethra
o Abdomianl distention
o vomiting if infant is fed
o Asymmetry in leg positions
o Asymmetry of the thigh fat folds
o After 3 months of age, asymmetry of rotation of the leg and apparent shortening of the affected leg
o Diminished movement in the affected side

Signs & tests
Pediatricians routinely screen all newborns and infants for hip dysplasia. There are several maneuvers that can detect a dislocated hip or a hip that is able to be dislocated. A hip that is truly dislocated in an infant should be picked up but some cases are subtle and some develop after birth, which is why multiple examinations are recommended. Some mild cases are "silent"; and cannot be picked up on physical exam.

Ultrasound of the hip is the most important imaging study and will demonstrate hip deformity. A hip X-ray joint X-ray) is helpful in older infants and children.

Treatment
In early infancy, positioning with a device to keep the legs apart and turned outward (frog-leg position) will usually hold the femoral head in the socket. If there is difficulty in maintaining proper position, a plaster cast may be applied and changed periodically to accommodate growth. Operative management may be necessary if early measures to reduce the joint (put the joint back in place) are unsuccessful, or if the defect is first detected in an older child.

Prognosis
If the dysplasia is picked up in the first few months of life, it can almost always be treated successfully with bracing. In a few cases surgery is necessary to put the hip back in joint.The older the age at diagnosis, the worse the outcome and the bigger the surgery needed to repair the problem.

Talipes equinovarus; Talipes or Clubfoot

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