Showing posts with label Reproductive Medicine. Show all posts
Showing posts with label Reproductive Medicine. Show all posts

07 May 2012

Female Reproductive Endocrinology



Female Reproductive System
Female Reproductive System.ppt

Female Reproductive Endocrinology
Joel Michael, PhD
GU block/Pregnancy.ppt

Reproductive Endocrinology
Reproductive Endocrinology.ppt

Female Reproductive System Aging
Female Reproductive System Aging.ppt

Endocrinology of reproduction
Reproductive endocrinology.ppt

Female Reproductive Endocrinology
Kenneth L. Campbell
FemaleRepro.ppt

Female Reproductive Endocrinology
Female Reproductive Endocrinology.ppt

Female Reproductive Endocrinology
Joel Michael, PhD
Female Reproductive Endocrinology.ppt

Female Reproductive Endocrinology
Female Reproductive Endocrinology.ppt

Female Reproductive System
Ricki Otten, MT(ASCP)SC
Female Reproductive Endocrinology-1.ppt
Female Reproductive Endocrinology-2.ppt

What is Assisted Reproductive Technology?
Amanda J. Weathers
Assisted Reproductive Technology.ppt

Female Reproductive Endocrinology
gonadalhormones.ppt

Female Reproductive Endocrinology
femalerepro,estrogen.ppt

26 January 2012

Sperm Disorders Ppts



Infertility Treatment
by: Joshua Prince, Preston Moore, Candace Lindler
Fertilization Specialists
https://camcom.ngu.edu/Science/biology/BIOL%203465/male%20reproductive%20problems.ppt

Male Reproductive System and Genitourinary Disorders
by Eva Talastas
http://webenhanced.lbcc.edu/vnjm/vn255jm/coursedocs/male.ppt

Developmental, Genetic,  & Pediatric Disease
http://nhscience.lonestar.edu/biol/durham/docs/biol2305/7%20Developmental,%20Genetic,%20&%20Pediatric%20Disease.ppt

Reproductive  Function & Disorders
bby Mandy  Vichas RN, BSN, NPS
http://facweb.northseattle.edu/gmihalyne/nur128/power%20points/SP08%20Reproductive%20Function%20&%20Disorders.ppt

Assessment  and Management of Patients with Endocrine  Disorders
by Linda Self
http://www.atu.edu/nursing/faculty_docs/self/Assessment_and_Management_of_Patients_with_Endocrine_Disorders.ppt

Male  Reproductive System
http://www.netc.edu/faculty/twright/MT%20_Ch07.ppt


01 September 2011

Female Genital Cutting



Female Genital Cutting
By:Safa Magid

Female Genital Cutting(FGC)
* Also known as: female circumcision & female genital mutilation
* Female circumcision is the term preferred by cultures who practice this custom

FGC -Definition
* Procedure involving partial or total removal of the external female genitalia or other injury to the female genital organs whether for cultural, religious, or other non-therapeutic reasons.

WHO Classification of FGC
* Type 1: Excision of prepuce w/ or w/o excision of all of the clitoris
* Type 2: Clitoridectomy and partial or total excision of labia minora
* Type 3: Infibulation, includes removing all or part of ext. genitalia and re-approximation of remnant labia majora, leaving a small interoitus for passage of urine and menstrual blood

Read more...

22 February 2010

Female Genital Cutting



Female Genital Cutting
By:Safa Magid

Female Genital Cutting(FGC)
* Also known as: female circumcision & female genital mutilation
* Female circumcision is the term preferred by cultures who practice this custom

FGC -Definition
* Procedure involving partial or total removal of the external female genitalia or other injury to the female genital organs whether for cultural, religious, or other non-therapeutic reasons.

WHO Classification of FGC
* Type 1: Excision of prepuce w/ or w/o excision of all of the clitoris
* Type 2: Clitoridectomy and partial or total excision of labia minora
* Type 3: Infibulation, includes removing all or part of ext. genitalia and re-approximation of remnant labia majora, leaving a small interoitus for passage of urine and menstrual blood

Read more...

11 January 2010

Male Reproductive Problems



Male Reproductive Problems
By:Fertilization Specialists
Joshua Prince
Preston Moore
Candace Lindler

Infertility
* Infertility is the inability of a couple to become pregnant
* 6.1 million people in the United States are effected

Treatment
Normospermia with functional defects
Asthenospermia and teratozoospermia
Oligospermia
Untreatable subfertility
Reversible toxin effects
Disorders of sexual function
Gonadotropin deficiency
Obstructive azoospermia
Sperm autoimmunity
Treatable conditions
Primary seminiferous tubule failure
Untreatable sterility
FREQUENCY (%)

TYPE OF INFERTILITY
Table 1. Classification Of Male Infertility By Effectiveness Of Medical Intervention To Improve Natural Conception Rate

* Sperm count equals the number of sperm per cm3 or cc
* The average has dropped in the past 20 years
* 85-90% are treated with medication or surgery
* Lifestyle changes

Normal Reproduction
* Ovulation
* Spermatogenesis
* Sperm meets with egg in fallopian tube
* Fertilization
* Implantation

Male Reproductive System
Female Reproduction System
Normal Spermatogenesis
Testes

* Normal Testes
* 10-14 grams
* Body of the testis
o Epididymis
o Spermatic Cord
* Embryonal Carcinoma
o hemorrhage and necrosis
* Spermatogonium (2N)
Differentiation
* Primary Spermatocyte (2N)
Meiosis I
* Secondary Spermatocytes
Meiosis II
* Spermatids
Differentiation
* Spermatozoa

Spermatogenesis
* Seminferous Tubules
90% of the testis
* Thousands of sperm per second although spermatogenesis 8-10 weeks
* Stored for months
* Degraded and deposited into the circulatory system if not ejaculated

Klinefelter Syndrome
* XXY instead of XX or XY
* usually male
* lower levels of testosterone
* improper formation of semineferous tubules

Bilateral Anorchia
* vanishing testes syndrome
* testes originally present but reabsorbed before or after birth

Oligospermia
* having too few sperm
* due to:
fever
excessive alcohol
smoking
varicocele
orchitis

Azoospermia
* total lack of sperm in ejaculate
* due to:
fever
undescended testicle
obstructions of seminal vesicles
testicle infection

Cryptorchidism
* 30% of males born premature
* 3% of males carried to term
* Predisposes the person to risk of torsion
* Androgen receptor
* Bilateral has six times the impact on infertility
* Increase in Temperature
* Testicular atrophy
* Treated at Childhood

Abnormalities

Read more...

Male Obesity and Semen Analysis Parameters



Male Obesity and Semen Analysis Parameters
By:Joseph Petty, MD
Samuel Prien, PhD
Amantia Kennedy, MSIV
Sami Jabara, MD

Background: Obesity

* Obesity is a growing problem.
* The Behavioral Risk Factor Surveillance System, in conjunction with the CDC, conducted a national survey and found that in 2000, the prevalence of obesity (BMI >30 kg/m2) was 19.8%, a 61% increase since 1991.
* Obesity affects female and male fertility.
* In a study comparing IVF success rates and female obesity, it was shown that a 0.1 unit increase in waist-hip ratio led to a 30% decrease in probability of conception per cycle 2.
* In couples complaining of infertility, male factor plays a role in up to 40% of cases.

Background: Semen Parameters
* What parameters best predict fertility?
* National Cooperative Reproductive Medicine Network: 765 infertile couples (no conception after 12 months), and 696 fertile couples
* greatest discriminatory power was in the percentage of sperm with normal morphologic features.

Hypothesis
* Since there is an observed correlation between obesity and male factor infertility, our hypothesis is that an increased BMI is associated with higher rate of abnormal semen parameters, especially sperm morphology.

Recent Studies
* Danish study by Jensen et al. enrolled 1,558 young men (mean 19 years old) when they presented for their compulsory physical exam as part of their country’s military drafting system.
* The authors showed decreased sperm counts and concentration (39 million/mL vs. 46million/mL) in those with an elevated BMI (>25kg/m2). They did not, however, observe a difference in morphology.
* Hormonal differences
* Kort et al. looked at semen analysis results in 520 men
* grouped according to their BMI, and measured the average normal-motile-sperm count (NMS = volume x concentration x %motility x %morphology)
* Kort concluded that men with high BMI values (>25) present with few normal-motile sperm cells
* Hammoud et al., showed a increased incidence of oligospermia and increased BMI and also showed decreased levels of progressively motile sperm
* Considered each parameter separately.

Sexual function
* Agricultural study: The association between BMI and infertility was similar for older and younger men, disproving the theory that erectile dysfunction in older men is a significant factor.
* Hammoud et al., though primarily concerned with hormones, looked at erectile dysfunction directly and showed that there was no correlation with increases in BMI
* Nguyen et al., effect of BMI is essentially unchanged regardless of coital frequency, suggesting that decreased libido in overweight men is not a significant factor

Hormonal Profile
* Danish study, observed decreased FHS and inhibin B levels in the obese.
* Pauli et al., observed with increases in BMI a decreased total T, decreased SHBG, increased estrogen and decreased FSH and inhibin B.
* Inhibin B, cited for its usefulness as a novel marker for spermatogenesis and its role in pituitary gonadotropin regulation.
* Pauli: no correlation of BMI or skinfold thickness with semen analysis parameters, though it was observed that men with proven paternity versus those without had lower BMI.

Interventions: Gastric Bypass

Read more...

28 July 2009

Male Reproductive System



Male Reproductive System
By:Linda Harmon

Male Reproductive System
* Several organs serve as parts of both the urinary tract and the reproductive systems.
* The structures are the tests, the vas deference and the seminal vesicles, the penis, certain accessory glands, such as the prostate and Cowper’s gland..
* Disorders in these organs may interfere with the function of either or both systems.
* Diseases are usually treated by a urologist.

Health History and Assessment
* Changes in urinary function and symptoms of obstruction caused by an enlarged prostate
* Changes in physical activity
* Sexual function and any manifestations of sexual dysfunction
* Factors that affect sexual functioning (stress, physical disease, use of medications, drugs, or alcohol)

Physical Examination
* Digital-Rectal Exam
o Recommended for every man over the age of 40
o Assess the size, shape, and consistency of the prostate
o Screening for cancer of the prostate
* Testicular Exam
o The male genitalia are inspected for abnormalities
o Note nodules, masses, or inflammation
o Instruct the patient about the technique for TSE

Diagnostic Studies
* Prostate-Specific Antigen
o The prostate gland produces a substance known as Prostate-Specific Antigen (PSA). This is measured in the blood and increases in prostate cancer. It needs to be drawn prior to a rectal exam or urinary catheterization.
* Ultrasound
o Transrectal ultrasound studies are used in detecting nonpalpable prostate cancers and in staging localized prostate cancers,. Needle biopsies of the prostate are commonly guided by ultrasound. Ultrasounds are more sensitive than a digital rectal exam.
* Prostate Fluid or Tissue Analysis
o A biopsy may be necessary to obtain tissue for histologic examination. This can be done with a prostatectomy or via a perineal or transrectal needle biopsy.
* Test of Male Sexual Functioning
o Usually conducted by a special team of health care providers.

Medications Associated with Erectile Dysfunction
* Antiadrenergics and antihypertensives
* Anticholinergics and phenothiazines
* Antiseizure agents
* Antifungals
* Antihormone
* Antipsychotics
* Antispasmodics
* Anxiollytics
* Betablockers
* Calcium channel blockers
* Carbonic anhydrase inhibitors
* H2 antagonists
* Nonsteroidal anti-inflammatory drugs
* Thiazides diuretics
* Tricyclic antidepressant

Conditions of the Prostate

Prostatitis
* Inflammation of the prostate gland caused by infectious agents or other conditions
* Clinical manifestations: perineal discomfort, burning, urgency, frequency and pain with or after ejaculation, fever, chills, rectal or low back pain, urinary tract infections.
* Complications: swelling, urinary retention, epididymitis, bacteremia, pyelonephritis.
* Management: avoid complications, broad spectrum antibiotic agent, bed rest, analgesic agents, antispasmodics, bladder sedatives, sitz baths. Chronic is difficult to treat.
* Nursing Management: antibiotics, comfort measures, analgesics, sitz baths, teaching.
* Self care: administration of antibiotics, sitz baths, fluids encouraged but not forced, foods and liquids with diuretic action or that increase prostatic secretions should be avoided.

Benign Prostatic Hyperplasia
* Enlargement of the prostate, extending upward into the bladder and obstructing the outflow of urine by encroaching on the vesical orifice.
* BPH is one of the most common pathologic conditions in men over 50
* Cause is uncertain
* Hypertrophied lobes cause incomplete emptying and urinary retention.
* Manifestations: frequency, nocturia, urgency, hesitancy, abdominal straining, decrease in volume and force of stream, interruption of stream, dribbling, urinary retention, recurrent UTI, fatigue, anorexia, nausea, vomiting, epigastric discomfort.
* Medical Management: Plan is dependent on cause, severity and condition. Immediate, hormonal, pharmacological, surgical

Cancer of the Prostate
* The most common cancer in men.
* Prostate cancer rates twice as high in African American men. They are more likely to die than men in any other racial or ethnic group.
* Risk factors: increasing age, African American, familial predisposition, diet high in red meat and fat
* Manifestations: urinary obstruction, difficulty and frequency, retention,decrease in size and force of stream, painful ejaculation, hematuria, late signs include backache, hip pain, perineal and rectal discomfort, anemia, weight loss, weakness
* Diagnosis: Early detection increases likelihood of cure. Over 40 requires a digital rectal exam (DRE) – early cancer may be detected as a nodule within the substance of the gland or as an extensive hardening in the posterior lobe.
* Men with prostate cancer experience sexual dysfunction before the diagnosis is made.
* Medical Management: based on the stage, age, symptoms. Surgical management, radiation therapy, hormonal therapy, others.
* Surgical Procedures: the procedure chosen depends on the size of the gland, the severity of the obstruction, the patients age, physical status, presence of associated diseases, and patient preference.
* Complications: hemorrhage, clot formation, catheter obstruction and sexual dysfunction.

Prostatectomy

Read more...

05 July 2009

Male Reproductive Problems



Male Reproductive Problems
By:Fertilization Specialists
Joshua Prince
Preston Moore
Candace Lindler

Infertility
* Infertility is the inability of a couple to become pregnant

Treatment
Normospermia with functional defects
Asthenospermia and teratozoospermia
Oligospermia
Untreatable subfertility
Reversible toxin effects
Disorders of sexual function
Gonadotropin deficiency
Obstructive azoospermia
Sperm autoimmunity
Treatable conditions
Primary seminiferous tubule failure
Untreatable sterility
FREQUENCY (%)

TYPE OF INFERTILITY
Table 1. Classification Of Male Infertility By Effectiveness Of Medical Intervention To Improve Natural Conception Rate
* Sperm count equals the number of sperm per cm3 or cc
* The average has dropped in the past 20 years
* 85-90% are treated with medication or surgery
* Lifestyle changes

Normal Reproduction
* Ovulation
* Spermatogenesis
* Sperm meets with egg in fallopian tube
* Fertilization
* Implantation

Male Reproductive System
Female Reproduction System
Normal Spermatogenesis
Testes
* Spermatogonium (2N)
Differentiation
* Primary Spermatocyte (2N)
Meiosis I
* Secondary Spermatocytes
Meiosis II
* Spermatids
Differentiation
* Spermatozoa
Spermatogenesis
* Seminferous Tubules
90% of the testis
* Thousands of sperm per second although spermatogenesis 8-10 weeks
* Stored for months
* Degraded and deposited into the circulatory system if not ejaculated
Klinefelter Syndrome
* XXY instead of XX or XY
* usually male
* lower levels of testosterone
* improper formation of semineferous tubules

Bilateral Anorchia
* vanishing testes syndrome
* testes originally present but reabsorbed before or after birth
Oligospermia
* having too few sperm
* due to:
fever
excessive alcohol
smoking
varicocele
orchitis

Azoospermia
* total lack of sperm in ejaculate
* due to:
fever
undescended testicle
obstructions of seminal vesicles
testicle infection

Cryptorchidism
* 30% of males born premature
* 3% of males carried to term
* Predisposes the person to risk of torsion
* Androgen receptor
* Bilateral has six times the impact on infertility
* Increase in Temperature
* Testicular atrophy
* Treated at Childhood

Abnormalities
* Testicular torsion
of the spermatic cord cuts off the venous drainage, leading to hemorrhagic infarction
It is the twisting of the spermatic cords
Immediate treatment
* Testicular cancer

Illnesses
* Acute
* Chronic
Orchitis
STDs
* Fibropapilloma
Stimulants
Age
Gynecomastia
* Testicular Failure
* Androgen receptors
* Cirrhosis
* Tumors
* Illegal steroid
* Feminine characteristics

Examination

Read more...

Male Obesity and Semen Analysis Parameters



Male Obesity and Semen Analysis Parameters
By:Joseph Petty, MD
Samuel Prien, PhD
Amantia Kennedy, MSIV
Sami Jabara, MD


Background: Obesity
Background: Semen Parameters
* What parameters best predict fertility?
* National Cooperative Reproductive Medicine Network: 765 infertile couples (no conception after 12 months), and 696 fertile couples
* greatest discriminatory power was in the percentage of sperm with normal morphologic features.

Hypothesis
Recent Studies
Sexual function
Hormonal Profile
Interventions: Gastric Bypass
Study Design
* Retrospective chart review for all couples and individual patients presenting for an infertility consultation and evaluation at the Texas Tech Physicians Center for Fertility and Reproductive Surgery from September 2005 through January 2008.
* Intake questionnaire: demographic, medical, surgical and fertility history.
Questionnaire
* Previous pregnancies fathered: current or previous partner

Read more...

Male Infertility



Male Infertility: Definitions
By:Jeanne O’Brien MD
Assistant Professor of Urology and Male Infertility
University of Rochester Medical Center, Department of Urology

Definitions
* Primary infertility: inability to achieve pregnancy > 1yr
* Secondary infertility: previously fertile, now unable >1 yr
* Azoospermia: no sperm in semen
* Oligospermia: reduced sperm concentration <20 million/ml
* Asthenospermia: reduced percent motility <50%
* Teratospermia: reduced percent normal forms <30%
* IVF: in vitro fertilization
* ICSI: intra-cytoplasmic sperm injection

Etiology of Male Infertility
* Varicocele
* Idiopathic
* Infection
* Genetic
* Endocrine
* Immunologic
* Obstruction
* Cryptorchidism

Male Infertility: Evaluation
* Basic Evaluation:
o History (Questionnaire)
o Physical examination
o Standard semen analysis
o Hormonal evaluation
* Optional Additional Evaluation:
o Genetic counseling and evaluation
o Specialized sperm function tests
o Imaging studies
o Testis biopsy

Male Infertility: History
* Duration of infertility
o Previous treatments
o Female-factor (anovulation, tubal obstruction)
* Sexual history
o timing and mechanics of intercourse
o lubricants (peanut oil, olive oil, egg whites ok)

History
* Childhood & Development
o cryptorchidism
o pubertal development
* Medical History
o systemic illness
* Surgical History
o abdominal, pelvic or scrotal surgery
* Infections
o STDs, prostatitis, orchitis (post-pubertal mumps)
* Environmental gonadotoxins
o smoking
o ETOH
o radiation, chemicals, pesticides, chemotherapy
o Heat exposure (short order cook, tanning booths, hot tub/bath)
* Medications (steroids, herbal supplements, hair growth products)

History: Medications
* Hormonal (pre-testicular)
o e.g. androgens, anti-androgens, estrogens
* Gonadotoxic (testicular)
o e.g. chemotherapy/alkylating agents
* Sperm-toxic (post-testicular)
o e.g. Ca-channel blockers

Anatomy of the male reproductive tract

Physical Examination
* General
o Body habitus (muscle mass), hair distribution
o Evidence of normal virilization
* CNS
o visual fields (r/o pituitary adenoma)
o sense of smell (Kallmann’s Syndrome - HypoHypo)
* Abdomen/Pelvis
o Surgical scars
* Genital/Prostate
* Penis:
o length (normal development)
o position of urethral meatus (deposition of semen)
* Prostate :
o size
o firmness
o tenderness
o presence of cysts (ejaculatory duct)
* Testis:
o -position (cryptorchid?)
o -volume (normal ~15-25ml)
o -firmness (normal = firm)

Testis:
o -Seminiferous tubules
+ Germ cells
+ Sertoli cells
o -Interstitium
+ Leydig cells
+ macrophages, endothelial cells
Spermatogenesis
o ~74 days in humans (epididymal transit ~15 days)
o Clinical correlate: Need to wait 3 months after any intervention (medical or surgical) to see a change in semen quality
* Epididymis:
o -fullness
o -cystic changes
* Vas deferens:
o -congenital absence of vas (CAVD)
+ Cystic fibrosis mutations
+ Woolfian duct anomalies

Genital tubercule Penis
Overview of sexual differentiation in the male
(modified from Male Reproductive Biology, eds Lipshultz, Howards)
Varicocele: Diagnosis
* Definition: dilated testicular veins due to reflux of blood
* Established by physical examination (in a warm room)
* Other modalities used to diagnose a sub-clinical varicocele:ultrasound, venography, doppler stethoscope
* However, the subclinical varicocele does not require repair!
* WHO Fertil Steril 1985
* Howards Fertil Steril 1992

Varicocele
* Etiology: probably multi-factorial
Varicocele: Prevalence

Read more...

28 June 2009

Endometrial Biopsy



Endometrial Biopsy
By:Lianne Beck, MD
Assistant Professor
Emory Family Medicine

Indications
* Abnormal uterine bleeding: postmenopausal bleeding, malignancy/hyperplasia, ovulation/anovulation, HRT
* Evaluation of patient with one year of presumed menopausal amenorrhea
* Assessment of enlarged utereus (combined with US and neg HCG)
* Monitoring adjuvant hormonal tx (tamoxifen)
* Evaluation of infertility
* Abnormal Pap smear with atypical cells favoring endometrial origin (AGUS)
* Follow-up of previously diagnosed endometrial hyperplasia
* Cancer screening (e.g., hereditary nonpolyposis colorectal cancer)
* Inappropriately thick endometrial stripe found on US
* Endometrial dating


Contraindications
* Pregnancy
* Acute PID
* Clotting disorders (coagulopathy)
* Acute cervical or vaginal infections
* Cervical cancer

Conditions Possibly Prohibiting Endometrial Biopsy
* Morbid obesity
* Severe pelvic relaxation with uterine descensus
* Severe cervical stenosis

Equipment
* Non-sterile Tray (Examination for Uterine Position)
o Nonsterile gloves
o Lubricating jelly
o Absorbent pad to place beneath the patient on the examination table
o Formalin container (for endometrial sample) with the patient's name and the date recorded on the label
o 20 percent benzocaine (Hurricaine) spray with the extended application nozzle *
* Optional Equipment
* Sterile Tray for the Procedure
o Sterile gloves
o Sterile vaginal speculum
o Uterine sound
o Sterile metal basin containing sterile cotton balls soaked in povidone-iodine solution
o Endometrial suction catheter
o Cervical tenaculum
o Ring forceps (for wiping the cervix with the cotton balls)
o Sterile 4 x 4 gauze (to wipe off gloves or equipment)

Procedure

Read more...

24 June 2009

Sexuality & Fertility Issues in Cancer Patients



Sexuality & Fertility Issues in Cancer Patients
bt:Carolyn Vachani, MSN, RN, AOCN

Scope of Sexuality Issues
* 40-100% of cancer patients experience some form of sexual dysfunction
* Issues do not always resolve after therapy
* Almost all cancer treatments have the potential to alter sexual function (surgery, chemotherapy, radiation, hormones)
* Represents major quality of life (QOL) issue
* With intervention, up to 70% of patients can have improved functioning

To Optimize QOL, Nurses Can:
* Learn evidence-based information on how diagnosis/treatment affects sexual function
* Conduct assessments before/during therapy
* Inform patients of possible changes
* Educate clients & partners
* Provide guidance & suggestions for adapting to changes
* Know resources & refer when needed

Survey of Physician/Patient Communications
Nurses’ Beliefs
Johnson’s Behavioral Model
PLISSIT Model for Communication
Sexual Dysfunction in Men
* Chemo/hormonal therapy: Erectile dysfunction, decreased libido, ejaculatory dysfunction, gynecomastia, penile/ testicular atrophy, and infertility
* Radiation/ brachytherapy: Urinary issues, impotence, bowel dysfunction, penile/ testicular atrophy
* Surgery: Urinary issues, impotence, body image, pain, retrograde ejaculation

Sexual Dysfunction in Women
* Chemo/Hormone therapy: Irregular menses, early menopause, hot flashes, insomnia, irritability, depression, vaginal dryness, painful intercourse, infertility, and decreased libido
* Radiation/ brachytherapy: Pelvic fibrosis, vaginal atrophy/stenosis, scarring, decreased lubrication, urinary effects, erythema, edema, ulceration, decreased elasticity, shortening, and increased irritation of vagina
* Surgery: Body image, bowel changes, ROM issues, menopause, pain, changes in vaginal size/sensitivity, loss of nipple

General Nursing Interventions
Ostomy Surgery: Interventions
Interventions for Male Issues
Interventions for Female Issues
Radiation-Induced Vaginal Stenosis
Other Interventions for Women
Resources
* www.eyesontheprize.org (online community for gynecologic cancers)
* Support groups (Gilda’s Club, Wellness Community)
* www.oncolink.org
* www.ustoo.org (prostate cancer website)
* www.fertilehope.org
* www.resolve.org (fertility)
* ACS Sexuality booklets
(available on ACS website)

Pregnancy & Treatment

Read more...

16 June 2009

Sexual Development



Sexual Development

UROGENITAL SINUS & TUBERCLE
VULVA
UTERUS
OVARY
VAGINA
UTERINE TUBE
MULLERIAN DUCT
SEXUAL DEVELOPMENT
PROSTATE
PENIS
SEMINAL VESICLE
RETE TESTIS
TUBULUS RECTUS
EFFERENT DUCT
EPIDIDYMIS
DUCTUS DEFERNS
BULBOURETHRAL GLAND
urethra
INTERSTITIAL CELLS
SEMINIFEROUS TUBULE
TESTIS
WOLFFIAN DUCT
MESONEPHRIC DUCT
PARAMESONEPHRIC DUCT
GONAD on hold
OVARY
TESTIS
INTERSTITIAL CELLS
SEMINIFEROUS TUBULE

Read more...

15 June 2009

Fertility Facts



Fertility Facts
Definition:unprotected sex for one year, not pregnant
What can cause infertility?
* Ovulation disorders
* Tube/uterus blockage
* Cervix
* Endometriosis
* Other
* Sperm count and defects
* Erectile or ejaculation deficiency

Intrinsic vs. Extrinsic, Environmental
More detail on female infertility
* Ovulatory failure-polycystic ovarian syndrome (high androgen/estrogenlevels), resistant ovarian syndrome, gonadal dysgenesis
* Impaired gamete/zygote transport-pelvic inflammatory disease, endometriosis
* Implantation defects-progesterone low
* Spontaneous abortion-chromosome abnormality

More detail on male infertility
* Cryptorchidism-Why?
* Chromosome disorders-gonadal dysgenesis
* Obstructions
* Gonadotropin deficiency
Result in:Low sperm count, sperm of poor quality

Female Infertility Tests
* For ovulation
* Post ovulatory block
Laparoscopy
Hysterosalpingogram
Blocked tubes
Male Infertility Tests
* Sperm count/motility
* If low check LH and androgen levels
* Testicular biopsy
Sperm Count
Older, low tech treatments
* Drug treatment for ovulation block
* Intrauterine insemination
* Tubal surgery

High tech Assisted Reproduction Technologies
* IVF-in vitro fert and embryo transfer
* GIFT-gamete intrafallopian tube transfer
* ZIFT-zygote intrafallopian tube transfer
* Intracytoplasmic sperm injection

frozen eggs/ ovary transplant; cloned human embryo
First test-tube baby

Assisted Reproductive Technology

Read more...

Male Sexual Anatomy & Physiology



Male Sexual Anatomy & Physiology

The Penis
* Nerves, blood vessels, fibrous tissue, and three parallel cylinders of spongy tissue.
* There is no bone and little muscular tissue (although there are muscles at the base of the penis)
* Terms:
* Penis: consists of internal root, external shaft, & glans.
* Root: the portion of the penis that extends internally into the pelvic cavity.
* Shaft: the length of the penis between the glans and the body.
* Glans: the head of the penis; has many nerve endings.
* Cavernous bodies: the structures in the shaft of the penis that engorge with blood during sexual arousal.
* Spongy body: a cylinder that forms a bulb at the base of the penis, extends up into the penile shaft, and forms the penile glans. Also engorge with blood during arousal.
* Foreskin: a covering of skin over the penile glans.

Fig 5.1a Interior structure of the penis:
External penile structures
Scrotum and testes
* Scrotum (or scrotal sac):
* Testis
o Male gonad inside scrotum that produces sperm and sex hormones
* Spermatic cord
o A cord attached to the testis inside the scrotum that contains the vas deferens, blood vessels, nerves, and muscle fibers
Structures inside the testis
Cross-section of seminiferous tubule
Interstitial cells: secrete androgens
Spermatogenic cells: produce sperm

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Reproductive Ethics



Reproductive Ethics

Schedule
* Papers
* Understanding the Technology
* Ethical Issues

Reproductive Technology
* Artificial Insemination
* In Vitro Fertilization
* Surrogacy
* Freezing Sperm
* Freezing Embryos
* Freezing Eggs
* (Cloning)

Artificial Insemination
* Essentially, sperm (either from the husband or some other donor) is injected into the reproductive tract of the intended mother.
* Used most commonly when there are concerns about male infertility.
* The sperm can be “washed” first to ensure that there is a high concentration of sperm.
* Actually a general term, not a specific procedure.
* The most common procedure is intrauterine insemination (IUI), where the sperm is inserted directly into the uterus, so as to avoid possible problems with the cervix.
* IUI has a success rate of about 15-20%, and is fairly quick.
* A major disadvantage is that the doctor cannot tell if insemination has been successful because it occurs in the body.
* Another procedure, intracytoplasmic sperm injection (ICSI) involves injecting a single sperm by pipette into an egg.
* ICSI allows men with very low sperm counts to reproduce.
* Can be done in utero, but is becoming more common in vitro.

In Vitro Fertilization
* In these processes, sperm and eggs are combined outside the body, and reinserted after it is clear that insemination has occurred.
* The most common sign that insemination is successful is when the egg has divided into an eight-celled organism. This is the point that the egg(s) are reinserted.
* Depending on the procedure used, can cost between $5,000 and $12,000 an attempt.
* The rate of success for IVF varies from clinic to clinic, and procedure to procedure, but the national average is about 34% (measured in terms of babies per egg retrieval.)

GIFT
* Gamete Intrafallopian Transfer (GIFT) is a hybrid of IVF and AI.
* Eggs and sperm are both retrieved from the potential parents, and screened for problems.
* The sperm and eggs are then placed in a catheter together and inserted directly into one the woman’s fallopian tubes.
* Since the eggs are withdrawn from the body first, GIFT is similar to in vitro, but since the fertilization occurs in the body it is like AI.
* Some find this preferable to traditional IVF, because there is no question about what to do with “excess” embryos.

Surrogacy

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Assisted Reproductive Technologies (ART)



Assisted Reproductive Technologies (ART)
* Artificial Inseminations
* In vitro fertilization (IVF)
* Embryo transfers
* “Cloning”

Some Common Reasons for ART
* Infertility
o Male
o Female
* Absence of one or the other partner
o Lesbian, gay, transgendered parent
o Death of spouse
* Genetic Engineering
o Hereditary disorders
o Sex selection

Artificial Insemination
* Method other than intercourse to facilitate fertilization
* Introduction of semen or washed sperm into the vagina, the uterus or the Fallopian tubes
* Can be from legally recognized partner (husband) = AIH, or from another donor = AID
* Fresh or frozen semen samples (e.g., Select Sires, Inc.)

Long History of AI
* Agricultural uses
o 14th Century breeding of Arabian horses
o 1780 Spallanzani used sperm in dog breeding
o By 1940 many breeders Coops
* Human experience
o John Hunter (1780s) patient with hypospadias
o Marion Sims (mid 1800s) one success out of 55 tries
o By 1941 over 10,000 births in the US by AI
o By 1955 over 50,000
o Now, approx 1 percent of all births in US

The Famous Turkey Baster
Sorting sperm according to sex
* Sperm are sexually dimorphic: half have an X-chromosome, half have a Y-chromosome
* The X-chromosome is much bigger, so “female determining” sperm have more DNA, and are (hypothetically) slightly heavier
* Try to physically separate sperm based on size or DNA content
* Mark either the X or Y chromosome in some way and sort on the basis of the marking.
More than one X chromosome: Sex chromatin (
Flow sorting of marked sperm
IVF: In vitro fertilization

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Sperm Terms



Sperm Terms

Sperm Count – # of sperm
Sperm Mobility- ability of sperm to move
Forward Progression- quality of movement
Sperm Morphology- size and shape of sperm

Factors in Decreased Spermatogenesis
* Exposure to Heat
* Lifestyle Factors
* Age
* Endocrine Problems
* Immunological Problems

Anatomical Problems
Retrograde Ejaculation

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Semen quality in relation to pesticides



Semen quality in relation to exposure to currently used pesticides
By:Shanna H. Swan, PhD
University of Missouri-Columbia
6th International Symposium on Environmental Endocrine Disrupters
Sendai, Japan

Background
Normal morphology
Motile sperm
Concentration

The Study for Future Families (SFF)
SFF Recruitment:
Summary of Semen Parameters

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