Showing posts with label Physiology. Show all posts
Showing posts with label Physiology. Show all posts

29 April 2012

Antidiuretic hormone Lecture Notes and 200 free full text articles



Antidiuretic hormone and the mineralcorticoids
ADH.ppt

Antidiuretic hormone and the mineralcorticoids
Dale Buchanan Hales, PhD
ADH.ppt

ADH: AntiDiuretic Hormone
Pat Hock RN
ADH: AntiDiuretic Hormone.ppt

Hormones of Water and Sodium Regulation
Hormones of Water and Sodium Regulation.ppt

Hormones of the Body
Dawn Tamarkin, Ph.D.
Endocrine.ppt

Diabetes Insipidus
Dr. Abdelaziz Elamin
Diabetes Insipidus.PPT

Mechanisms of hormone release
Mechanisms of hormone release.ppt

Syndrome of Inappropriate ADH Secretion
Tracy Merrill MD
ADH Secretion.ppt

Reabsorption and Secretion
Reabsorption.ppt

Endocrine System
Endocrine System.ppt

Functions of the Endocrine System
Functions of the Endocrine System.PPT

Fluid, Electrolyte and Acid-Base Balance
Fluid, Electrolyte and Acid-Base Balance.ppt

Major Functions of the Kidneys and the Urinary System
Kidneys and the Urinary System.ppt
200 free full text articles

13 January 2010

Protein Digestion and Absorption



Protein Digestion and Absorption

* Dietary proteins, with few exceptions, are not absorbed.
* Dietary proteins, with few exceptions, are not absorbed.
* They must be digested first into amino acids or di- and tri-peptides.
* Dietary proteins, with few exceptions, are not absorbed.
* They must be digested first into amino acids or di- and tri-peptides.
* Through the action of gastric and pancreatic proteases, proteins are digested within the lumen into medium and small peptides (oligopeptides).


Digestion of protein - hydrolysis
Protein digestion begins in stomach
Pepsin - inactive precursor pepsinogen
Active @ pH 2-3, inactive pH>5
Secretion stimulated by acetylcholine or acid
Only protease which can break down collagen
Action terminated by neutralisation by bicarbonate in duodenum.
N.B. **All proteases (stomach & pancreatic) secreted as inactive precursors. Most protein digestion occurs in the duodenum/jejunum

Activation of pancreatic proteases
Trypsinogen
Trypsin
Enterokinase
Trypsinogen
Chymotrypsinogen
Proelastase
Procarboxypeptidase
Trypsin
Chymotrypsin
Elastase
Carboxypeptidase
Active proteases inactivated by trypsin
peptidases
aminopolypeptidase
transporters
amino acids
Di/tri peptides
Cytoplasmic peptidase

Pancreatic enzymes
Essential for digestion
essential for life
Proteases
Inactive form
Activated in gut
Acinar cells
Lipases Amylases
Active enzymes

Pancreatic Enzymes
* The bulk of protein digestion occurs within the intestine due to the action of pancreatic proteases.

Pancreatic Proteases
* The two primary pancreatic proteases are trypsin and chymotrypsin.
* They are synthesized and packaged within secretory vesicles as inactive proenzymes:
trypsinogen chymotrypsin
* The two primary pancreatic proteases are trypsin and chymotrypsin.
* They are synthesized and packaged within secretory vesicles as inactive proenzymes:

trypsinogen chymotrypsin
The secretory vesicles also contain a trypsin inhibitor to serve as a safeguard against trypsinogen converted to trypsin.

Other Pancreatic Proteases
* Procarboxypeptidase  carboxypeptidase
* Proelastase  elastase

Trypsin
* Trypsinogen is converted to trypsin by the enzyme enterokinase (enteropeptidase) secreted by cells lining duodenum.
* Trypsinogen is converted to trypsin by the enzyme enterokinase (enteropeptidase) secreted by cells lining duodenum.
* Trypsin then activates the conversion of other zymogens from their inactive to active forms.
* Trypsinogen is converted to trypsin by the enzyme enterokinase (enteropeptidase) secreted by cells lining duodenum.
* Trypsin then activates the conversion of other zymogens from their inactive to active forms.
* Inhibition of trypsin will slow activation of other proteases.
* Trypsin catalyzes the splitting of peptide bonds on the carboxyl side of lysine and arginine residues.
* It has a pH optimum of 7.6 to 8.0 (alkaline).
* Classified as a serine protease (serine and histidine at the active site.

Trypsin, Chymotrypsin
* Similar chemical compositions
* Chief differences are specificity of action:
trypsin – lysine, arginine
chymotrypsin – tyrosine, phenylalanine, tryptophan, methionine,leucine
(aromatic or large hydrophobic side chains)

Lock and Key Model of Enzyme Activity

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15 July 2009

Physiology Presentations



Physiology Presentations from ksums.net

Properties of Cardiac Muscle.ppt

Endo Introduction.ppt

Renal Physiology.pdf

Male Reproductive System.pdf

Endo Thyroid gland.pdf

Female Reproductive System.pdf

Respiratory physiology.ppt

Acid Base Regulation.ppt

Acid Base Regulation Modified.ppt

Acid Base Abnormality

Parathyroid Gland%20& Calcium Homeostasis.ppt

Pregnancy and Lactation.ppt

Read more...

15 June 2009

Male Sexual Anatomy & Physiology



Male Sexual Anatomy & Physiology

The Penis
* Nerves, blood vessels, fibrous tissue, and three parallel cylinders of spongy tissue.
* There is no bone and little muscular tissue (although there are muscles at the base of the penis)
* Terms:
* Penis: consists of internal root, external shaft, & glans.
* Root: the portion of the penis that extends internally into the pelvic cavity.
* Shaft: the length of the penis between the glans and the body.
* Glans: the head of the penis; has many nerve endings.
* Cavernous bodies: the structures in the shaft of the penis that engorge with blood during sexual arousal.
* Spongy body: a cylinder that forms a bulb at the base of the penis, extends up into the penile shaft, and forms the penile glans. Also engorge with blood during arousal.
* Foreskin: a covering of skin over the penile glans.

Fig 5.1a Interior structure of the penis:
External penile structures
Scrotum and testes
* Scrotum (or scrotal sac):
* Testis
o Male gonad inside scrotum that produces sperm and sex hormones
* Spermatic cord
o A cord attached to the testis inside the scrotum that contains the vas deferens, blood vessels, nerves, and muscle fibers
Structures inside the testis
Cross-section of seminiferous tubule
Interstitial cells: secrete androgens
Spermatogenic cells: produce sperm

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07 June 2009

Refresher Course on Cellular Homeostasis



Refresher Course on Cellular Homeostasis
from APS Education online
Organizers:Michael F. Romero, Ph.D. and Jeffrey C. Freedman, Ph.D.

The goal of this Refresher Course was to provide an overview of recent advances in areas of cellular homeostasis. The talks provided information that may not be readily available in a standard textbook.

In the beginning ... There was the cell (ppt file)
Michael F. Romero, Ph.D., Case Western Reserve University

Generation of the Membrane Potential (ppt file)
Steven H. Wright, Ph.D., University of Arizona College of Medicine

Ion Homeostasis, Channels, and Transporters: An Update on Cellular Mechanisms (ppt file)
George R. Dubyak, Ph.D., Case Western Reserve University

Cellular Volume Homeostasis (ppt file)
Kevin Strange, Ph.D., Vanderbilt University

Cellular pH Homeostasis (ppt file)
Walter F. Boron, M.D., Ph.D., Yale University

Refresher Course on Respiratory Physiology



Refresher Course on Respiratory Physiology
from APS Education online

Click on the title for Audio+presentation

  • Introduction
    L. Britt Wilson, Ph.D.
    University of South Carolina School of Medicine
  • Mechanics of Breathing
    John B. West, M.D., Ph.D., D.Sc.
    University of California, San Diego School of Medicine

Refresher Course on GI Physiology



Refresher Course on GI Physiology
from APS Education online

Click on the title for audio+presentation

Refresher Course on Gender Differences in Physiology



Refresher Course on Gender Differences in Physiology
from APS Education online

The APS Education Committee and Teaching Section sponsor courses on physiology topics during the APS annual meeting, Experimental Biology. Courses are designed to provide both an intensive overview of content in one of the areas of physiology and opportunities to review new teaching methods and materials for physiology instruction. They are targeted especially for non-specialists who have teaching responsibilities in the refresher course's content area.

Introduction

Martha L. Blair, Ph.D.
University of Rochester

Sex Steroid Effects on Different Target Tissues: Mechanism of Action

Margaret E. Wierman, M.D.
Physiology and Biophysics
University of Colorado
Denver Health Sciences Center

Cardiovascular System: Gender Differences in Normal Function and Disease

Virginia H. Huxley, Ph.D.
Director, National Center for Gender Physiology
University of Missouri-Columbia School of Medicine

Skeletal Muscle and Bone: Effects of Sex Steroids and Aging

Marybeth Brown, Ph.D.
Physical Therapy
University of Missouri-Columbia

Common Auto-immune Signaling Defects: What Does Gender Have to Do With It?

Denise Faustman, M.D., Ph.D.
Director, Immunobiology Laboratory
Massachusetts General Hospital
Harvard Medical School

10 May 2009

Insulin Secretion, Beta Cell Biology



Insulin Secretion, Beta Cell Biology and the Pathogenesis of Type 2 Diabetes


Kenneth S. Polonsky
Presentation by:Professor of Medicine, Cell Biology and Physiology
Director Institute of Clinical and Translational Sciences
Washington University School of Medicine

Diabetes:Basic Abnormalities
Islets of Langerhans
GLUCOSE
Pancreas
Muscle
Liver
Fat

INSULIN
* The pancreas does not produce enough insulin
* Muscle, liver and fat tissues don’t respond to insulin-insulin resistance
* Elevated Fatty Acids impair insulin secretion and action

Normal Glucose Tolerance
Genetic susceptibility
Diabetogenic Lifestyle
Normal Glucose Tolerance
Insulin Resistance
Compensatory hypersecretion of insulin
Impaired Glucose Tolerance
Insulin Resistance
β-cell compensation starts to fail
Overt Hyperglycemia
Insulin Resistance
Failed β-cell compensation

Read more...

08 May 2009

Human Anatomy and Physiology ppt lectures



Human Anatomy and Physiology
Presentation lectures by:R. Adam Franssen, PhD
Roane State Community College

• Muscle Tissue Lectures week 1
• Muscle Tissue Lectures weeks 2 and 3
• Blood Lectures weeks 4 and 5
• Heart Lectures weeks 5 and 6
• Blood Vessels week 7
• Lymphatic System weeks 9 and 10
• Respiratory System weeks 11 and 12
• Digestive System weeks 12 and 13
• Urinary System week 14

02 May 2009

Physiology video presentations



Physiology video presentations
from University of Wisconsin

Date
Presentation
07/15/2008 Picture from Physiology of Alcohol video
K. Strang
03/13/2008 Picture from Altitude Adaptation and Illness video
F. Luyet
02/14/2008 Picture from Energy Metabolism in the Failing Heart: Should We Intervene? video
J. Ralphe
01/03/2008 Picture from Inducible Intrapulmonary Arteriovenous Shunts: A Paradigm Changing View of the Pulmonary Circulation video
M. Eldridge
10/04/2007 Picture from Channel Surfing in Pediatrics video
C. Stafstrom
View description
Dr. Stafstrom will speak on: 1) Structure, function and genetics of ion channels 2) Disorders of ion channel function - "channelopathies" 3) Ion channels as therapeutic targets
06/21/2007 Picture from Arterial Stiffening and Cardiovascular Disease video
N. Sweitzer
View description
Nancy Sweitzer, MD, PhD, assistant professor in the Department of Cardiovascular Medicine at the University of Wisconsin-Madison, speaks on "Arterial Stiffening and Cardiovascular Disease" at the Health Sciences Learning Center on June 21, 2007.
05/17/2007 Picture from Location, Location, Location: Why Neighborhood Matters to an Ion Channel and for Arrhythmias video
T. Kamp
View description
Timothy J. Kamp, MD, PhD, an associate professor of medicine and the associate director of the Medical Scientist Training Program at the University of Wisconsin-Madison speaks on "Location, Location, Location: Why Neighborhood Matters to an Ion Channel and for Arrhythmias" at the Health Sciences Learning Center.
04/09/2007 Picture from Everything You Ever Wanted to Know about Sexual Health video
M. Wilhite
View description

30 April 2009

Sexual Anatomy & Physiology



Sexual Anatomy & Physiology
Presentation by: Dr. Penny Frohlich
University of Texas at Austin

Female External Genitalia

Vulva: everything that is externally visible (mons pubis, labia majora, labia minora, clitoris, urethral orifice, vaginal vestibule, perineal body)
mons pubis: mound of fatty tissue above the pubic bone
labia majora: large, outer fatty folds of skin tissue
labia minora: inner folds of skin and erectile tissue
clitoris: small, highly sensitive organ
glans: tip of the clitoris
prepuce (clitoral hood): loose-fitting fold of skin covering the clitoral glans
vaginal vestibule: the cleft containing the vaginal and urethral openings
Skene’s glands: group of small mucous glands that open into vaginal vestibule (near urethra)
Bartholin’s glands: two glands that open into vaginal vestibule (on either side of the vaginal opening) - thought to provide some lubrication, may emit a pheromone
hymen: thin mucous membrane partially covering the vaginal opening
perineum: tissue between the genital and anus.

Normal Variations

Female Internal Genitalia
Vagina: tubular organ connecting external genitals with uterus
Grafenberg spot (g-spot):

o mass of erectile and glandular tissue surrounding the urethra just below the bladder
o some women report that simulation to g-spot produces sexual arousal and orgasm

uterus: hollow muscular organ - purpose to nurture developing fetus

cervix: small lower portion of the uterus that projects into the vagina
cervical os: small opening in the cervix allowing passage of fluids between the uterus and vagina
myometrium: layers of smooth muscle comprising the uterus
endometrium: inner lining of the uterus that builds a rich blood supply and sloughs off the lining each month (if conception does not occur)

ovaries: female gonads - containing the immature female reproductive cells
ovum: female reproduce cell
fallopian tubes: thin flexible muscular structures connecting the ovaries with the uterus - passageway for the ovum to travel to the uterus
cilia: tiny hairlike projections that line the fallopian tubes and propel the ovum towards the uterus
fimbriae: fringelike projections that reach out to the ovary to draw a released ovum into the fallopian tube.

Sexual Response
Arteries & Veins
Female Internal Genitalia: Muscles

* Pelvic floor muscles
o Ischiocavernosus: acts to drive blood into the body of the clitoris
o bulbocavernosus: helps to maintain the structure of the pelvic tissue and serves as a vaginal sphincter

Female Internal Genitalia: Nerves
* Sexual arousal: stimulation to tactile and temperature receptors on the genitalia, breasts, etc.
* Orgasm: genital reflex governed by the spinal cord

Male External Genitalia

penis: male copulatory organ
frenulum: underside of the penis, between shaft and glans
glans: enlarged conic structure at the tip of the penis
corona: raised rim or ridge of tissue that separates the glans from the shaft
prepuce (forskin): loose-fitting retractable casing of skin that forms over the glans
smegma: accumulation of secretions on the penile glans from glands of foreskin
circumcision: surgical procedure involving removal of the prepuce
scrotum: skin-covered pouch containing the testes

corpora cavernosa: two large and uppermost cylindrical masses of penile tissue
corpus spongiosum: lower, smaller cyhlindrical mass of tissue in the penis, contains the urethra
crura: tapering part of the corpora cavernosa - forms the connection to the pubic bone
Testes: oval, glandular organs contained in the scrotum - produce sperm, secrete male hormones

Read more...

The Appendicular Skeleton



The Appendicular Skeleton

* Limb bones and their girdles are appended, or attached to the axial skeleton
* The pectoral girdle attaches the upper limbs to the trunk
* The pelvic girdle secures the lower limbs
* The upper and lower limbs differ in their functions but share the same structural plan

The Pectoral Girdle

* Consists of the clavicle and the scapula
- do not completely encircle the body
* Medial end of each clavicle articulates with the manubrium and first rib
* Laterally, the ends of the clavicles join the scapulae
- scapulae do not join each other

Pectoral Girdle Functions

* Provides attachment for many muscles that move the upper limb
* The girdle is light allows upper limbs to be mobile
* Only the clavicle articulates with the axial skeleton
* Glenoid cavity - socket of the shoulder joint is shallow
- good for flexibility but bad for stability

Clavicles (‘Little Keys’)

* Aka collarbones are slender and S-shaped
* Extend horizontally across the superior thorax
* The flattened acromial end articulates with the scapula laterally
* The cone-shaped sternal end attaches to the manubrium medially


Clavicle Functions

* Provide attachment for muscles
* Act as braces - holds the scapulae and arms out laterally from the thorax
- a fractured clavicle will cause the entire shoulder region to collapse
* Transmits compression forces from the upper limbs to the axial skeleton
- allows you to push a heavy object

Scapulae

* Are thin, triangular flat bones located on the dorsal surface of the rib cage
- between rib 2 superiorly and rib 7 inferiorly
* 3 borders: Superior – shortest and sharpest;
Medial (vertebral) – parallels the vertebral column;
Lateral (axillary) – abuts the axilla and ends superiorly in the glenoid cavity (shallow fossa)
* 3 angles: Lateral – by the glenoid cavity;
Superior – the superior and medial borders meet;
Inferior – junction of the medial and lateral borders
* Biceps muscle
* Articulates with the humerus
* Suprascapular nerve
* Subscapularis muscle

Muscles:

* Infraspinatus
* Supraspinatus

The Upper Limb

* 30 bones – arm, forearm, and hand
* Humerus – only bone of the arm
- longest and strongest bone of the upper limb
- articulates with the scapula at the shoulder
- articulates with the radius and ulna at the elbow
- provides sites for muscle attachment
- provides articulation sites for other bones

* Rotator cuff muscles

Read more...

29 April 2009

Upper Cervical Spine Fractures



Upper Cervical Spine Fractures
Presentation lecture by:Daniel Gelb, MD

Upper Cervical Spine Fractures

* Epidemiology
* Anatomy
* Radiology
* Common Injuries
* Management Issues

Upper Cervical Spine Fractures
* Epidemiology
o Cause
+ MVC 42%
+ Fall 20%
+ GSW 16%
o Gender
+ Male 81%
+ Female 19%

Etiology of Spinal Cord Injury by Age
Upper Cervical Spine Fractures
Upper Cervical Anatomy
C1 - Atlas
Anatomy – The Atlas
C2 Anatomy
Anatomy – The Axis
Anatomy – The Ligaments
AtlantoAxial Anatomy
Tectorial Membrane
AtlantoAxial Anatomy
occiput
Tranverse Ligament
C1-C2 joint
Alar Ligament
AtlantoAxial Anatomy
Transverse
Ligament
Facet for Occipital Condyle


AtlantoAxial Anatomy

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The Skeletal System



The Skeletal System
The Axial Skeleton presentation lecture from:NORTHLAND COMMUNITY & TECHNICAL COLLEGE

* Axial Skeleton
o 80 bones
o lie along longitudinal axis
o skull, hyoid, vertebrae, ribs, sternum, ear ossicles
* Appendicular Skeleton
o 126 bones
o upper & lower limbs and pelvic & pectoral girdles

Types of Bones

* 5 basic types of bones:
o long = compact
o short = spongy except surface
o flat = plates of compact enclosing spongy
o irregular = variable
o sesamoid = develop in tendons or ligaments (patella)
* Sutural bones = in joint between skull bones

Bone Surface Markings

* Surface features-- rough area, groove, openings, process
* Specific functions
o passageway for blood vessels and nerves
o joint formation
o muscle attachment & contraction
* Foramen = opening
* Fossa = shallow depression
* Sulcus = groove
* Meatus = tubelike passageway or canal
* Condyle = large, round protuberance
* Facet = smooth flat articular surface
* Trochanter = very large projection
* Tuberosity = large, rounded, roughened projection
* Learning the terms found in this Table will simplify your study of the skeleton.

The Skull

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