Clinical Pharmacology of Anti-cancer Chemotherapeutic Agents

Clinical Pharmacology of Anti-cancer Chemotherapeutic Agents
By:Dr. Jeff R. Wilcke

Therapeutic Principles Diagnosis & Drug Selection
Absorption
Distribution
Metabolism
Elimination
Toxicity &/OR
Efficacy
Pharmacokinetics
Pharmacodynamics
Therapeutic Endpoints
* Efficacy without toxicity
o Human medicine: palliative therapy only
o Veterinary medicine: palliative therapy probably?
* Efficacy AND toxicity
o Human and veterinary medicine: aggressive, curative therapy
* Toxicity without efficacy
o Tentative administration
+ You may affect bone marrow ONLY rather than bone marrow AND tumor
o Drug Resistance
+ Reduces tumor response, bone marrow still sensitive
* Neither toxicity nor efficacy

Dosing v. P’kinetic End Points
Dose vs AUC Target
Peak Concentration
AUC
Intensity / Time Above
Absorption
* Oral
* Intramuscular
Activation
* Hepatic
* Intracellular phosphorylation
* Tissue metabolism with free radical production
Distribution
Elimination
Dosing Chemotherapeutics
Body Surface Area
Oral Chemotherapy
IM Chemotherapy
Intravenous Chemotherapy
Gemcitabine
Dose Form Manipulation

Clinical Pharmacology of Anti-cancer Chemotherapeutic Agents.ppt