Clinical Pharmacology of Anti-cancer Chemotherapeutic Agents

Clinical Pharmacology of Anti-cancer Chemotherapeutic Agents
By:Dr. Jeff R. Wilcke

Therapeutic Principles Diagnosis & Drug Selection
Absorption
Distribution
Metabolism
Elimination
Toxicity &/OR
Efficacy
Pharmacokinetics
Pharmacodynamics
Therapeutic Endpoints
* Efficacy without toxicity
o Human medicine: palliative therapy only
o Veterinary medicine: palliative therapy probably?
* Efficacy AND toxicity
o Human and veterinary medicine: aggressive, curative therapy
* Toxicity without efficacy
o Tentative administration
+ You may affect bone marrow ONLY rather than bone marrow AND tumor
o Drug Resistance
+ Reduces tumor response, bone marrow still sensitive
* Neither toxicity nor efficacy

Dosing v. P’kinetic End Points
Dose vs AUC Target
Peak Concentration
AUC
Intensity / Time Above
Absorption
* Oral
* Intramuscular
Activation
* Hepatic
* Intracellular phosphorylation
* Tissue metabolism with free radical production
Distribution
Elimination
Dosing Chemotherapeutics
Body Surface Area
Oral Chemotherapy
IM Chemotherapy
Intravenous Chemotherapy
Gemcitabine
Dose Form Manipulation

Clinical Pharmacology of Anti-cancer Chemotherapeutic Agents.ppt

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Tumors and Vascular diseases of the Brain

Tumors and Vascular diseases of the Brain
By:Jennifer Villa Frabizzio, M.D.
* Abington Memorial Hospital
* Radiology Group of Abington, PC
* Board Certified in Diagnostic Imaging with Added Qualifications in Neuroradiology

Topics for Discussion
Neuroimaging Then and Now
Neuroanatomy
Vascular and Nonvascular
Diagnosis and Treatment
Tumors
Primary and Metastatic Disease
Neuroimaging- Then
Standard Radiograph
Pneumoencephalography
Direct Cerebral Angiography
Direct Cerebral Arteriography
Neuroimaging-Now
Computed Tomography
* Advanced techniques
CT angiography and venography
* CT perfusion
Magnetic Resonance Imaging (MRI)
Neuroimaging Nonvascular
Vascular diseases Stroke
Trauma/Intracranial Hemorrhage
Aneurysm
Arteriovenous Malformations
Stroke
case study
Anoxic brain injury
Intracranial Hemorrhage
Aneurysms
Arteriovenous Malformations (AVM)
Brain Tumors

Tumors and Vascular diseases of the Brain.ppt

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U.S. Public Health Service Perinatal Guidelines

U.S. Public Health Service Perinatal Guidelines

Recommendations for the Use of Antiretroviral Drugs in Pregnant HIV-1 Infected Women for Maternal Health and to Reduce Perinatal HIV-1 Transmission in the United States.

Perinatal Guidelines

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