Blood Brain Barrier: Structure, Function and Bypass by Microorganisms

Discovery
What is the Blood Brain Barrier?
Structure of Blood Brain Barrier
Integrity of BBB
Astrocyte end feet
Tight Junctions between BMEC
Claudin
Occludin
Barrier Function of Occludin and Claudin
Junction Adhesion Molecules:
BMEC intercellular space
Barrier function of JAM
Cytoplasmic accessory proteins
Membrane associated guanylate kinase-like proteins (MAGUKS)
Adherens Junction
Pericytes
Astrocyte end feet
Circumventricular organs
Circumventricular organ functions:
Normal BBB transport
Factors produced by astrocytes
Glutamate,
Aspartate
Taurine
ATP
Endothelin-1
NO
MIP-2
Tumor necrosis factor alpha TNF-α
Interleukin beta IL-β
Bradykin
5HT
Histamine
Thrombin
UTP
UMP
Substance P
Qionolonic acid
Platelet activating factor
Free radicals
E. Coli model
Physical damage of BBB
Ligand receptor interactions followed by host cell actin cytoskeletal rearrangements
Transcellular transport while maintaining integrity of BMEC
Physcial damage of BBB
Conclusion
References



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