Cigarette Smoking Addiction Treatment

Tackling  the smoking epidemic - Smoking cessation guidance for primary care
http://www.theipcrg.org/resources/resources_smokingcessation/smokingcessationslides.ppt

Treating  Tobacco Dependence In  Smokers With Co-Occurring  Substance Abuse Or Mental  Health Disorders: Scientific  Overview
Judith  J. Prochaska, PhD, MPH
http://casat.unr.edu/docs/KEYNOTE_jjprochaska_Yakima.ppt

Are  the 5A's Enough?: Tobacco  Dependence Treatment for  Smokers with Mental  Illness
National Conference  on Tobacco or Health
http://smokingcessationleadership.ucsf.edu/Presentation07/5A.ppt

Panic  Symptoms, Cigarette Smoking and Drinking in Adolescent Female Twins
Michele  Pergadia, Andrew C. Heath, Kathleen  K. Bucholz, Elliot C. Nelson, Christina  N. Lessov†, Donald F. Klein, Pamela  A.F. Madden
http://www.alcoholdependence.org/2%20Poster%2018%20-Michelle.ppt
http://alcoholdependence.wustl.edu/guze/Documents/1_Pergadia_03.ppt

Smoking  in The Elderly Population
http://www.ehle-project.eu/final_materials/en/TRAINING%20PROFESSIONALS/SMOKING_handbook_EN.ppt

Tobacco  Addiction, Why is It so Powerful?
Gaylene  Mooney, M.Ed, RRT-NPS
http://www.aarc.org/resources/tobacco/documents/tobacco_addiction.ppt

Nicotine  and smoking: insights  from the Health Survey  for England
Martin  Jarvis
http://www.ccsr.ac.uk/esds/events/2004-10-29/Slides/Jarvis.ppt

Welcome to  smoking cessation – an interactive workshop designed to assist general practitioners
http://www.heartfoundation.org.au/SiteCollectionDocuments/ILC-Presentation-Smoking.ppt

The Tobacco Consultation How We Do It & What we teach your patients!
Jay Taylor, RRT, TTS
http://www.askadviserefer.org/downloads/tobacco%20Consult2.ppt

Implementing  Successful Cessation Program
http://www.ghi-ctp.emory.edu/documents/Cessationprograminhospitals.ppt

Cigarette  Cravings and the Self-Regulation of Smoking
Michael  Sayette
http://www.publichealth.pitt.edu/docs/Sayette-ReSET-June09.ppt

Maternal & Child Health and  Smoking
http://www2.aap.org/richmondcenter/DownloadablePresentations/MaternalChildHealth.ppt

Are outcome  expectancies the possible targets of smoking  prevention?
http://kozegeszsegtan.sote.hu/tobacco/user_files/110614getwxq825575.ppt

Nicotine addiction
Royal  College of Physicians  of London
http://old.rcplondon.ac.uk/pubs/books/tag/3-Nicotine_addiction.ppt

Crushing virtual  cigarettes helps reducing tobacco addiction.
Final results from a preliminary control trial
Girard1, B., Turcotte1, V., & Bouchard, S.
http://www.grap.ca/site/francais/documents/stop_smoking09.ppt

Neurochemical Effects of Nicotine
http://www.vdha.net/documents/tobacco_cessation/Pfizer-Medical%20Strategies%20for%20Tobacco%20Dependence.ppt

Nicotine  Addiction: Bio-Psycho-Social Aspects of Addiction
http://www-nehc.med.navy.mil/downloads/bumed/tcrof_cd/nicotineaddiction.ppt

Cigarette Smoking PDFs

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Subacute Sclerosing Panencephalitis Ppt

Subacute sclerosing panencephalitis (SSPE) is a rare chronic, progressive encephalitis that affects primarily children and young adults, caused by a persistent infection of immune resistant measles virus (which can be a result of a mutation of the virus itself). No cure for SSPE exists, but the condition can be managed by medication if treatment is started at an early stage.

Viruses,  Viroids, and Prions
Lectures  prepared by Christine L. Case
Viruses,  Viroids, and Prions.ppt

Subacute-sclerosing  panencephalitis (SSPE)
Virology/NegStrandRNA2005B.ppt

Paramyxoviruses Measles, mumps,  parainfluenza virus, respiratory syncytial virus,  human metapneumovirus
AM_Paramyxo.ppt

Global  Health Update: Travel  & Tropical Medicine Seminar
Tropical Medicine Seminar.ppt

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Diabetes Drug Improves Glucose Control Without Increasing Risk of Hypoglycemia

Diabetes Drug Improves Glucose Control Without Increasing Risk of Hypoglycemia

Too high? Too low? Only about half of those with type 2 diabetes have their blood sugar levels on target, but a new drug shows promise in managing glucose levels.  TAK-875 works by boosting the release of insulin from pancreatic B cells, but only when diabetics need it most – such as when glucose and fatty acids rise in the blood after a meal.

TAK-875, a new treatment for type 2 diabetes, improves blood sugar control and is equally effective as glimepiride, but has a significantly lower risk of creating a dangerous drop in blood sugar, called hypoglycemia, according to a new study.

Takeda Pharmaceutical has reported the positive results from its Phase 2 trial of TAK-875 in patients with type 2 diabetes.

TAK-875 is a selective agonist of GPR40, one of the GPCRs that are expressed in pancreatic islet cells.

The Phase 2 trial is a randomized double-blind placebo- and active (glimepiride) comparator-controlled multicenter study, intended to evaluate once-daily treatment with five different doses of TAK-875 (6.25 mg, 25 mg, 50 mg, 100 mg, and 200 mg) and glimepiride (2 mg -4 mg), over 12 weeks.

The study showed that at doses ranging from 6.25 to 200 mg a day, the drug has met its primary endpoint of significantly lowering HbA1c (blood glucose) levels.

The primary objective of the study is the change from baseline in HbA1c levels at week 12, while the secondary endpoints included fasting blood glucose, area under the curve (AUC) for glucose and insulin during an oral glucose tolerance test (OGTT), and body weight.

Takeda Development therapeutic area head Thomas Strack said because of its observed ability to potently stimulate insulin secretion and improve glycemic control with less or no hypoglycemia, these data further support TAK-875 as a potential therapy for the treatment of type 2 diabetes.

TAK-875 is the first GPR40 agonist to reach late-stage Phase 3 clinical development, the company said.
The results of the phase 2 randomized trial were published in The Lancet.

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http://dx.doi.org/10.1016/S0140-6736(11)61879-5

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