03 August 2009

Eating Disorders, Obesity & Sleep Disorders



Eating Disorders, Obesity & Sleep Disorders

Eating Disorders
* Characterized by severe disturbances in eating behavior
* Types of eating disorders:
o Anorexia Nervosa (peak onset – 14-18 yrs)
o Bulimia Nervosa (peak onset – late adolescence to early adulthood)
o Binge-eating Disorder (unknown)

Anorexia Nervosa
* Essential features:
o Refusal to maintain a minimally normal body weight (for height and age)
o Intensely afraid of gaining weight
o Exhibit a severe disturbance in perception of shape/size of one’s body
o Absence of at least 3 consecutive menstrual periods
* Self-esteem highly dependent on shape/size
* Refusal to maintain minimal body weight:
o Generally weigh less than 85% of the normal body weight
* Weight loss is usually a result of:
o Reduction of food
o Purging (vomiting, laxatives)
o Excessive exercise regimes
* Intensely afraid of gaining weight:
o Fear of becoming fat is not alleviated by weight loss
o Weight loss is seen as an impressive achievement and a sign of self-discipline
o Weight gain is viewed as failure of self-control
* Distorted view of body weight and shape
o Some feel overweight all over, no matter how thin they become
+ Others feel that a particular part of the body is “too fat”
o Some demonstrate excessive weighing
+ Measure body parts
+ Use mirrors to check body parts for fat
* Resulting physiological problems:
o Constipation, impaired renal functioning
o Cold intolerance  lanugo
o Emaciation, yellowing of the skin, dry skin
o Tend to lose 20-25% of body weight, some lose up to 35%;
o Cardiovascular/heart problems, amenorrhea, osteoporosis & death

Bulimia Nervosa

* Essential features:
o Binge eating
o Inappropriate compensatory methods to prevent weight gain
o Binge eating and compensatory behaviors must occur, on average, at least 2x/wk for 3 months
o Perception of self is excessively influenced by one’s body shape and weight.
* Binge eating:
o Eating an amount of food that is definitely larger than most individuals would eat under similar circumstances
+ Binges can last up to 2 hours
o Could occur in one setting or as a continuation of eating

* Food consumed typically includes sweet, high-caloric foods
* Usually ashamed of the eating problem
o Attempt to hide their symptoms

* Binge eating usually occurs in secrecy, or as inconspicuously as possible:
o Binges may be planned in advance
o Usually characterized by rapid consumption
o Eating continues until person is uncomfortably, even painfully full
o The individual experiences a sense of a lack of control during the binge-eating episode

* Recurrent use of inappropriate compensatory behaviors:
o 80-90% of binge eaters who seek treatment report self-induced vomiting  relief from discomfort/fear of gaining weight  eventually can vomit at will
o Others use laxatives, diuretics and enemas
* Compensatory behaviors (cont.)
o Individuals with bulimia may fast for a day or more to compensate for binges
o They may compensate by exercising excessively

* Similar to Anorexia Nervosa in that the individual:
o Has a fear of gaining weight
o Has a desire to lose weight
o Are dissatisfied with their bodies

* Different from Anorexia Nervosa in that:
o Individuals with Bulimia recognize their behavior is not normal
+ People with Anorexia Nervosa don’t
o Despite behaviors, weight is usually normal
+ People with anorexia become very thin
o Individuals with Bulimia are more likely to seek and respond to treatment.

* Resulting physiological problems:
o Skin irritations (esp. around mouth and fingers due to contact with stomach acid)
o Tooth decay and cavities
o Damaged taste receptors
o Abdominal pain, bowel problems
o Digestive disorders
o Possible cessation of menstruation

Theoretical Perspectives: Anorexia and Bulimia Nervosa

* Sociocultural factors:
o http://www.youtube.com/watch?v=knEIM16NuPg
o http://www.youtube.com/watch?v=I0u0wWOMIsE&feature=related
o Social learning theory:
o Purging is a negative reinforcer; it alleviates the fear of gaining weight
* Cognitive theory:
o Behaviors are a result of irrational thoughts

* Family factors
o Tend to be dysfunctional
+ Critical, less nurturing, overprotective
+ Mother tends to feel daughter is unattractive and needs to lose weight
o Identified patient
* History of childhood physical/sexual abuse
o Especially with bulimia

* Biological factors:
o Low serotonin levels may prompt binge eating in people with bulimia, esp. carbohydrate cravings
o Genetics
+ Eating disorders tend to run in families

Binge Eating Disorder
* Essential features:
o Binge eating without purging or compensatory behaviors
o Must average at least 2 episodes/week for 6 months or longer
o Impaired control over eating
o Experience significant distress due to the eating behavior
* Impaired control over eating:
o Eating rapidly
o Eating until painfully full
o Eating large amounts when not hungry
* Significant distress
o Eating alone out of embarrassment
o Feeling disgust, guilt or depressed after the eating episode
o Concern over how episodes will affect body size/shape

* Associated features:
o Some episodes are triggered by depression or anxiety
+ Others report no specific trigger, though report the behavior initially relieves tension
o Some report a dissociative quality during the episodes
o Most are overweight & were yo-yo dieters.

Obesity: A Chronic Medical Disease
* Weighing 20% above the recommended weight
* Americans eat 815 billion calories daily
o That’s 200 billion more than is necessary to maintain their weight
o Those extra calories would sustain a country of 80 million people
* Potential Causes
o High set-point
o Genetics
o Hypothalamus
o Coping technique
o Clock-watchers
o Addiction
o Eat too much + inactivity

Sleep Disorders
* Dyssomnias:
o Disorders in which a person has difficulty getting to sleep, staying asleep or sleeping too much
* Characterized by a disturbance in the:
o Amount of sleep
o Quality of sleep
o Or the timing of sleep
* Dyssomnia disorders include:
o Primary Insomnia
o Primary Hypersomnia
o Narcolepsy
o Breathing-Related Sleep Disorder
o Circadian Rhythm Sleep Disorder

Primary Insomnia
* Essential features:
o Difficulty falling asleep, staying asleep, or awakening too early that lasts at least one month (some report nonrestorative sleep)
o Causes distress or impairment in social, occupational or other important areas of functioning
* Some facts:
o As much as 30% of the population suffers from this; 9-15% have chronic bouts; nearly everyone has bouts at some point
o Primarily affects middle-age and older pop.; affects more females than males
* Most probable cause of insomnia – stress
o Person goes to bed  thinks about the days events or problems in life  mind races  can’t get to sleep  think about the fact s/he can’t get to sleep causes bodily arousal and more anxiousness  makes it even less likely s/he will get to sleep

* Question
o What should you do if you don’t fall asleep within about 20 minutes of getting in bed?

Primary Hypersomnia

* Essential feature:
* Excessive sleepiness for at least 1 month
o Prolonged sleep episodes
o Daytime sleep episodes which occur almost daily
o Must be severe enough to cause distress or impairment in social, occupational or other important areas of functioning

Primary Hypersomnia
* Duration of major sleep episodes range from 8-12 hours
o Often followed by difficulty awakening
* Excessive sleep during normal waking hours takes the form of
o Intentional naps
o Inadvertent episodes of sleep
* Daytime naps
o Are relatively long (lasting an hour or more)
o Are not refreshing
o Do not lead to heightened alertness
* Unintentional sleep episodes occur in low-stimulation and low-activity situations
o Such as?
* Hypersomnia can lead to distress and dysfunction:
o Difficulty in meeting morning obligations
o Unintentional daytime sleep episodes can be dangerous and embarrassing
o Low level of alertness can lead to poor efficiency, poor concentration, and poor memory

Narcolepsy
* Essential features:
o Repeated irresistible attacks of refreshing sleep
o Cataplexy and/or
o Intrusion of REM sleep between wakefulness and periods of sleep
* For diagnostic purposes, the sleep attacks must occur daily over a period of at least 3 months

* Repeated irresistible attacks of refreshing sleep:
o Sleep is irresistible; results in unintended sleep in inappropriate places
o Sleep episodes usually last 10-20 minutes, but can last up to an hour
o Individuals typically have 2-6 daily episodes
+ some attempt to control sleepiness by taking naps

* Cataplexy: Loss of muscle tone during episodes (usually lasts only seconds):
o Can be subtle or dramatic
o Person is fully conscious/alert during episode
o Occurs in approx. 70% of cases
+ Often develops years after onset
+ Triggered by strong emotions

* Approx. 20-40% experience intense dreamlike imagery:
o Hypnagogic hallucinations – just prior to falling asleep
o Hypnopompic hallucinations – just after awakening
o Most hallucinations are visual and incorporate elements of one’s environment

* Approximately 30-50% of individuals with narcolepsy experience sleep paralysis:
o Occurs just on falling asleep or awakening
o Individual is awake but unable to move or speak
+ Some feel like they can’t breathe
o Hallucinations and paralysis can occur simultaneously
+ Typically lasts seconds–minutes, ends abruptly

Narcolepsy

* Causes:
o Unknown
o May be genetic – higher degree of incidence among biological relatives
o May be partly due to a loss of certain brain cells in hypothalamus
+ Produce sleep-regulating chemical

Breathing-Related Sleep Disorder
* Essential feature:
o Sleep disruption, leading to excessive sleepiness or insomnia, that is due to abnormalities of ventilation during sleep
o Daytime sleepiness is the most frequently reported complaint

* Obstructive sleep apnea syndrome
o Temporary cessation of breathing during sleep
+ Seems to be a result of blocked upper air passages, causing breathing to stop temp.
# Enlargement of soft tissue may cause airways to narrow
+ May also be the result of structural deformities
+ Cessation of breathing lasts from 15-90 seconds
+ Individual may wake up as many as 500x/night
o Individual may wake up gasping for air, making a loud snorting sound, and go back to sleep
+ Individual is usually not aware of these interruptions of sleep
o Approx. 20 million Americans suffer from this disorder; men are 2x as like as women to suffer from it; usually occurs in overweight people

* Things that may help:
o Dieting
o Surgery (tonsils and adenoids)
o Dental appliances which reposition the tongue
o Ventilating machines

Circadian Rhythm Sleep Disorder
* Essential features:
o Disruption of normal sleep wake pattern
o Must be severe enough to cause severe distress or impairment of social, occupational or other important functioning
o Result of jet lag, working swing shifts, etc

Parasomnias
* Sleep disorders characterized by abnormal behavior or physiological events that occur in association with:
o Sleep
o Specific sleep stages or
o Sleep-wake transitions
* Usually complain of unusual behavior during sleep

Parasomnias

* Parasomnias include:
o Nightmare Disorder
o Sleep Terror Disorder
o Sleepwalking Disorder

Nightmare Disorder

* Essential Feature:
o Repeated occurrence of frightening dreams that lead to awakenings from sleep
o Must result in significant distress or result in social or occupational dysfunction

* Nightmares defined:
o A lengthy, elaborate dream sequence that is highly anxiety provoking or terrifying
* Dream content:
o Usually focuses on imminent danger to the individual
+ Sometimes the danger is more subtle, as involving personal failure or embarrassment

* Nightmares may replicate a real life traumatic experience a person had
o But not usually
* Individuals are alert upon wakening
o Can describe the dream in detail
* Occur almost exclusively during REM sleep
* Believed to be caused by stress

* Upon awakening, the individual experiences a lingering sense of anxiety or fear  difficulty returning to sleep
* Some individuals avoid sleeping, resulting in
o Excessive sleepiness
o Poor concentration, irritability
o Depression/anxiety

Sleep Terror Disorder
* Def: repeated abrupt awakenings from NREM sleep accompanied by:
o Intense physiological arousal
o Feelings of panic
* Often occurs during times of stress
* Most frequently occurs in children (up to 6%); rare in adults (<1%)
* Typical experience (lasts 1-10 minutes):
o Wake up in a state of panic, screaming
+ Body is in full physiological arousal
o Child may thrash about while still sleeping
o If awakened, the child is usually confused and incoherent
+ Soon fall back into deep sleep

Sleep Terror Disorder

o Children do not remember the incident in the morning; more terrifying to the parent
o Sleepwalking and sleep-talking may accompany sleep terror disorder
* Typically outgrown by adolescence
o Though some cases last into adulthood
* Cause is unknown
o But it is thought to be associated with stress

Sleepwalking Disorder

* Essential features:
o Arising from bed and walking about while asleep
* During episodes, the person has
o Reduced alertness/responsiveness
o A blank stare
o Is unresponsive to communication with others or efforts to wake them

Sleepwalking Disorder

* Individual typically has little recall of the incident upon awakening
* For diagnosis, the sleepwalking must cause severe distress or impairment of social or occupational functioning

* Sleepwalking episodes can include a variety of behaviors:
o May sit up in bed, look around, pick at blankets
o May walk into closets, out of the room, down stairs and even out of a building
o Some use the bathroom, eat or talk
o On occasion, some run from a perceived threat
o Some have operated machinery

* Particularly during childhood, sleepwalking can include inappropriate behavior
o E.g. Urinating in a closet
* Individuals often wake up in another place
o Or with evidence they performed some activity
* Most episodes last minutes to half an hour
* Cause: Unknown
o Genetics and environment may be involved

Eating Disorders, Obesity & Sleep Disorders.ppt

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Sleep and Sleep Disorders



Sleep and Sleep Disorders
The Science of Sleep
By:Robert Averbuch, MD
Assistant Professor of Psychiatry

Lecture Outline

* Physiology of Normal Sleep
o Non-REM
o REM
o Normal patterns of sleep
* Sleep Disorders
o Dyssomnias
o Parasomnias

Physiology of Normal Sleep

2 Phases: REM and Non-REM Sleep

Non-REM Sleep

* 4 stages of progressively deeper sleep
* Normal muscle tone
* Associated with increased 5HT (serotonin)
* Decreased autonomic activity:
o Lower BP, Pulse, respirations slow

Stage One
* Brief transition between wakefulness and sleep (accounts for only 5% of sleep time)
Stage Two
* Light sleep
* Accounts for 50% of total sleep time
* ElectroEncephaloGram (EEG) shows some characteristic findings…

EEG in Stage 2
Stages 3,4

* Most restful, restorative stages of sleep
* Aka: Delta wave sleep/ slow wave sleep
* Greatest proportion is in the first 1/3 to 1/2 of night

NREM Sleep: Theories of its purpose…

* The decrease in metabolic demand on the brain during NREM allows glycogen stores to replenish
* Allows for consolidation of memories and learning

REM (dreamland)

* 10-20 min. cycles consisting of:
o Rapid Eye Movements
o ElectroEncepahaloGram shows fast activity very similar to wakeful EEG pattern
o Suppression of peripheral muscle tone
o Penile Tumescence
o Often increased autonomic tone- ie, increased blood pressure, resp, heart rate

REM (dreamland)

* Where dreaming occurs
* REM is marked by increased cholinergic activity
o Thus REM-supression seen with anti-cholinergic drugs (ex. some antidepressants)

Normal Sleep Pattern
* Sleep cycles between NREM and REM approx. 4-5 times/night
* Cycles last approx. 90min
* REM duration and frequency increase thru night
* Proportion of slow wave sleep (stages 3,4) decreases thru night

Normal Sleep Parameters
* Sleep Onset Latency- the time it takes one to fall asleep, averages 10-20min
* REM Latency- time between sleep onset and the first REM period, averages 90-120min

Normal Sleep Distribution
* REM sleep accounts for approximately 25% of total sleep time
* Non-REM sleep accounts for 75% of sleep time, with 25% of that spent in Stages 3,4 (most restful portion)

Sleep Onset
* Mediated by increased Serotonergic activity in the Dorsal Raphe Nuclei of the Pons
o Dampens activity in the ascending reticular activating system (RAS), inducing sleep
* Dopamine has opposite effect- promotes wakefulness

Age-Related Changes

* Decreases in dreaming, total sleep time, REM, and slow-wave (deep sleep)
* Increases in early morning awakening, fragmentation, daytime napping, and phase advancement-
o Ie, earlier to bed, and awaken earlier

“Measuring” Sleep
Polysomnography

The Polysomnogram

* EEG, ECG
* EOG (oculogram)
* Chin EMG (myelogram)
* Ant. Tibialis EMG
* Pulse Oxymeter
* Blood Pressure

Sleep Disorders
Sleep Disorders- 2 Divisions

* Dyssomnias- disorders of quality, timing, or amount of sleep (quantity)
* Parasomnias- abnormal behaviors associated with sleep or sleep-wake transition, that often produce arousals

Dyssomnias
* Primary Insomnia
* Narcolepsy
* Sleep Apnea
* Circadian Rhythm Sleep Disorder (jet lag, et al.)
* Restless Legs Syndrome (RLS)
* Medical/Substance related insomnia

Primary Insomnia
* “Primary”, meaning no underlying medical cause
* Onset often with stressor or disruption to sleep schedule or environment
* Results from poor sleep hygiene, along with classical conditioning-
o Faulty learning/association of sleep environment with state of arousal

INSOMNIA- an epidemic?
* Definition: “Subjective” experience of poor sleep quality or quantity that adversely affects daily functioning
* Extremely common complaint in general practice
* 30-40% adults have occasional poor sleep
* 15-20% adults have chronic insomnia

Consequences of Insomnia
* Depression
* Irritability
* Decreased cognitive functioning
* Decreased productivity
* Injuries and accidents

Narcolepsy
* A dyssomnia characterized by poor sleep quality (restless, fragmented) and dysfunction in the transitions between sleep and wakefulness
* Presents with Excessive Daytime Sedation (EDS)

Narcolepsy Tetrad

* Classic tetrad of associated findings:
o 1. Sleep attacks
o 2. Cataplexy
o 3. Sleep paralysis
o 4. Sleep hallucinations

1. Sleep Attacks
* Most common symptom of the tetrad
* Brief (10-20min) “power-naps”- refreshing and restful
* Average 10-20/wk

2. Cataplexy
* Sudden loss of muscle tone (rarely full body paralysis) caused by intrusion of REM activity into daytime wakefulness
* Triggered by heightened emotion
* Average duration: 30 seconds
* No loss of consciousness

3. Sleep Paralysis
* Brief paralysis upon waking
* Remain alert with full eye movements Can occur in the absence of Narcolepsy (ie, normal variant)

4. Sleep Hallucinations
* Hypnogogic hallucinations- occur during transition into sleep
* Hynopompic hallucinations- occur upon awakening from sleep
* Can occur in the absence of Narcolepsy (ie, normal variant)

Narcolepsy: Etiology
* CNS lesions: brain trauma, stroke, tumor, Multiple Sclerosis
* Familial/idiopathic: onset in adolescence or young adulthood

Sleep Apnea
* Dyssomnia characterized by poor sleep quality due to frequent awakenings (apneas)
* Apneas last sec-minutes- produce brief arousal
* Presents with excessive daytime sedation- EDS

Sleep Apnea: Two Types
* Obstructive Sleep Apnea: most common
* Central Sleep Apnea

Obstructive Sleep Apnea
* Classic- obese, middle-aged male with thick neck or enlarged tonsils
* Apneas- brief gasps…silence, followed by loud “resuscitative” snores, and sometimes body movements (restless)
* Usually unaware of snoring, arousals…but sleep partner is aware

Central Sleep Apnea
* Apneas- episodic cessation of central ventilation drive
o Thus snoring is less common
* More in elderly, with underlying CNS lesions- ex. tumor, stroke

Sleep Apnea: Consequences
* Depression
* Anxiety
* Morning headaches
* Cognitive dysfunction
* Hypertension

Restless Legs Syndrome
* Paresthesias and/or dysesthesias in the legs, relieved by movements
* Usually occur in transition from wakefulness to sleep

RLS Causes
* Peripheral neuropathies
* Peripheral vascular disease
* Medication side effects
* Anemia
* Pregnancy
* Renal failure

Circadian Rhythm Disorders
* Delayed Sleep Phase Syndrome
* Jet Lag
* Accelerated Sleep Phase Syndrome
* Shift Work Sleep Disorder

Insomnia from Medical Conditions
* Reflux (GERD)
* Nocturia
* Peripheral neuropathies
* Breathing problems- Asthma, COPD
* Heart Disease/Failure
* Pain conditions

Psychiatric Causes of Insomnia
* Depression
* Anxiety
* Psychosis
* Substance intoxication/withdrawal

Sleep and Sleep Disorders.ppt

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29 July 2009

Fungal Presentations



Fungal Presentations from:fungalforum.com

High Dose AmBisome Treatment: what do we know?
By:V-J Anttila, Specialist in Infectious Diseases
Helsinki University Central Hospital, Finland

INVASIVE ASPERGILLOSIS
Management with liposomal amphotericin B
By:Michael Ellis

Is invasive aspergillosis hospital or community acquired: reassessing the evidence?
By:Malcolm Richardson PhD, FIBiol, FRCPath
Department of Bacteriology & Immunology
University of Helsinki, Finland

Invasive fungal infections in immunocompetent patients Does it exists ?

Antifungal combination therapy: where are we?
By:Malcolm Richardson. University of Helsinki.

Emerging fungal pathogens: clinical usefulness of new diagnostic tools

Update on glucan detection
By:Malcolm Richardson PhD, FIBiol, FRCPath
Department of Bacteriology & Immunology
University of Helsinki

Is azole prophylaxis a double-edged sword?
By:Malcolm Richardson PhD, FRCPath
Senior Lecturer in Medical Mycology
University of Helsinki, Finland

Clinical Findings in Rare and Emerging Fungal İnfections
By:Dr. Murat Akova
Hacettepe University School of Medicine
Section of Infectious Diseases
Ankara, Turkey


Liposomal amphotericin B: 20 years of clinical experience
By:Luis Ostrosky-Zeichner, MD, FACP
Assistant Professor of Medicine and Epidemiology
University of Texas Health Science Center at Houston

Antifungal and Surgical Management of a Case of Maxillary Sinus Aspergilloma
By:Riina Rautemaa
DDS, PhD, Consultant of Oral Microbiology
Helsinki University Central Hospital Maxillofacial Clinic and Laboratory Diagnostics;
and Haartman Institute, University of Helsinki, Finland


AMPHOTERICIN B NEPHROTOXICITY
By:GILBERT DERAY
PARIS , FRANCE

Changing Epidemiology:
The Importance of Broad Spectrum Therapeutics
By:Cornelia Lass-Flörl
Innsbruck Medical University

Antifungal treatment: Past and Present
By:Malcolm Richardson, PhD, FIBiol, FRCPath
University of Helsinki

Is combination antifungal therapy a viable option for the future?
By: Brian L Jones
Glasgow Royal Infirmary, UK

Fungal infections in solid organ transplantation recipients
By:Malcolm Richardson PhD, FIBiol, FRCPath
University of Helsinki and Helsinki University Central Hospital

Ten years experience of liposomal amphotericin B, AmBisome treatment in solid organ transplant recipients (SOT)

Advances in Empirical Antifungal Therapy in Patients with Febrile Neutropenia.
By:Marc A. Boogaerts

Does azole prophylaxis confer resistance to amphotericin B and influence virulence?
By:Malcolm Richardson
Department of Bacteriology & Immunology Haartman Institute
University of Helsinki

Liposomal amphotericin B: 20 years of clinical experience
The body of knowledge and familiarity of use
By:Malcolm Richardson PhD, FIBiol, FRCPath
Associate Professor in Medical Mycology
University of Helsinki, Finland

Prophylaxis of invasive fungal infections in high risk patients with hematologic malignancies
By:Olaf Penack

Read more...
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