26 July 2009

Pharmacology Presentations Part-1



Pharmacology Presentations from Howard University College of Medicine

Anticoagulant, Antithrombotic and Anti-Platelet Drugs
By: Robert Taylor, MD, Ph.D.

Antiviral Agents
By:Jillian H. Davis

Antiepileptic Drugs 1, 2, 3, 4
By:Martha I. Dávila-García, Ph.D.

Routes of Drug Administration 1, 2, 3
By:Robert L. Copeland, Ph.D.

Tetracyclines, 2
By:Martha I. Dávila-García, Ph.D.

Pediatric and Perinatal Pharmacology
By: Martha I. Dávila-García, Ph.D.

Antiepileptic Drugs
By:Martha I. Dávila-García, Ph.D

Penetration of drug into the eye after systemic Administration

Antidepressants
By:Martha I. Dávila-García, Ph.D.

Clinical Toxicology
By:Joseph Hanig, Ph.D.

Acid-Peptic Disease PUD/GERD/NSAIDs
By:Duane T. Smoot, M.D., FACP, FACG

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16 July 2009

Chest Trauma



Chest Trauma
by:Kent J. Blanke, D.O., FACOS
Introduction
Thoracic Trauma
Penetrating Chest Injuries
* Majority are stab wounds or gunshot wounds (GSW)
* Lower mortality rates--less likely to include multiorgan injury
* 85% of penetrating chest wounds can be treated with tube thoracostomy and supportive measures
Penetrating Chest Trauma
* Wounds that enter or exit inferior to the nipple or the posterior tip of scapula may perforate the dome of the diaphragm.
* Any penetrating wound such as this should be considered to have an abdominal component until proven otherwise.

Penetrating Chest Trauma: Treatment
* ATLS protocol: A,B,C,D,E’s
* Emergency management
o Needle thoracentesis
o Tube thoracostomy
o Subxiphoid pericardotomy
o Video assisted thoracic surgery (VATS)

Work-up of Penetrating Chest Trauma
* Physical examination
o Look, Listen, Feel
o Contusions, diminished or absent breath sounds, SQ emphysema can readily be found
* CXR- best, least expensive and fastest initial evaluation
* Ultrasound-may soon replace CXR as initial radiographic study in chest trauma
* Angiography- to look for great vessel injuries
* CT Scan: for better evaluation of chest wall and parenchyma
* Transesophogeal Echocardiography

Penetrating Chest Injuries
* Operative intervention required for:
o Massive or persistent bleeding
o Massive air leak
o Tracheobronchial injuries
o Esophageal perforation
o Cardiac or great vessel injuries
o Post-traumatic empyema
* Wounds that enter or exit inferior to the nipple or the posterior tip of scapula may perforate the dome or the diaphragm.
* Any penetrating wound such as this should be considered to have an abdominal component until proven otherwise.

Penetrating Chest Trauma:Indications for Mechanical Ventilation
Intrapulmonary Foreign Bodies
* Bullets, fragments: indications for removal
Intrapulmonary Foreign Bodies
Pulmonary Parenchymal Laceration
High Velocity Missile Injuries
Blunt Chest Trauma
Categories of chest wall injuries
* Open pneumothorax
* Contusion and Hematoma
* Sternal fractures
* Scapular fractures
* Flail chest
* Intercostal vessel injury
Categories of Intra-thoracic Injuries
* Pulmonary
o Pneumothorax, hemothorax
o Pulmonary contusion
o Pulmonary laceration
* Vascular
o Great vessel disruption (Ao dissection, pulmonary vasculature)
* Cardiac
o Blunt Cardiac Injury, Penetrating injury

Work-up of Blunt Chest Trauma
* Physical examination
o Look, Listen, Feel
o Contusions, diminished or absent breath sounds, SQ emphysema can readily be found
* CXR- best, least expensive and fastest initial evaluation
* Ultrasound-may soon replace CXR as initial radiographic study in chest trauma
* Angiography- to look for great vessel injuries
* CT Scan: for better evaluation of chest wall and parenchyma
* Transesophogeal Echocardiography

Categories of chest wall injuries
* Contusion and hematoma

Categories of chest wall injuries
* Open pneumothorax
* Pneumothorax
Operative Intervention for Hemothorax
* As noted previously
* Hemothorax: massive = initial drainage more than 1,000 cc or
* Continuous bleeding of 200 cc/hr for 2 hrs

Fractured Ribs: Chest Wall Trauma
Blunt Cardiac Injury
Categories of chest wall injuries
* Sternal fractures
Categories of chest wall injuries
* Scapular fractures
* Flail chest
Pulmonary Contusion
Intra-thoracic Trauma: Pulmonary Contusion
Intra-thoracic Trauma: Great Vessel and Mediastinal Trauma
* Aorta
* Pulmonary vessels
* Tracheobronchial lacerations
* Esophageal lacerations

Intra-thoracic Trauma: Great Vessel and Mediastinal Trauma—Work-up
* Plain CXR to identify thoracic aorta injuries
* Look for air in the mediastinum
* Persistent airleak should cue into:
o Bronchopulmonary or tracheobronchial injury
* Mediastinitis, tube feedings in chest tube or saliva in chest tube should cue into:
o Esophageal injury
* Bronchoscopy
* Esophagoscopy
* CT
* Serial CXR

Initial CXR of Concern

Indications for Angiography
* Lateral deviation of the NGT in esophagus
* Widened mediastinum (>8cm)
* Loss of visualization of the aortic knob
* Hematoma of the Left cervical pleura (pleural cap)
* Depressed left main stem bronchus
* Rt lateral deviation of the trachea
* Widened mediastinum (>8cm)
* Forward displacement of the trachea on the lateral CXR
* Fx of the 1st or 2nd rib
* Massive chest trauma w/ multiple rib fx
* Fx or dislocation of the thoracic spine
* Major deceleration injury
Complete Aortogram

Chest Trauma.ppt

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Radiographic Findings in Blunt Chest Trauma



Soft Tissue Radiographic Findings in Blunt Chest Trauma
By:Jonathan Yarris MSIV

Trauma
* Trauma is the leading cause of death in patients < 40 years
* 4th leading COD overall
* 80% of trauma is due to blunt mechanisms

Blunt Chest Trauma (BCT)
* Seen in about ½ of blunt trauma cases
* ~20% of trauma deaths attributable to BCT
* Etiology: typically deceleration injury
* Radiographic evaluation should begin immediately after initial trauma team assessment

Approach to Trauma Radiographs
* Initial exclusion of life threatening injuries
* Followed by search for less critical injuries
* Life threatening Injuries:
Pneumothorax
Deep Sulcus Sign
Tension Pneumothorax
Tension PTX
Pulmonary Contusion
Laceration
Laceration with Pneumatocele
Hematoma
Pulmonary hematoma
Pneumatocele
Pulmonary Contusion with pneumatocele
Blunt Cardiac Injury (BCI)
Hemopericardium
Great Vessel Injury
Thoracic Aorta Injury
Intimal Flap with double lumen
Airway Injury
* Tracheobronchial tears are uncommon
* Leads to persistent PTX
* Specific Symptom: persistent PTX after chest tube placement
* Finding: “Fallen Lung Sign”, pneumomediastinum, pneumopericardium, sub cut. Emphysema
* ET Tube balloon inflation >2.8cm implies tracheal rupture
Pneumomediastinum
* Etiology: alveolar, tracheobronchial or esophageal rupture
* Most common cause: alveolar rupture due to sudden increased intra-alveolar pressure (Macklin Effect) with air tracking centrally
* Findings:
o Air outlining mediastinal soft tissues and parietal pleura.
o Continuous diaphragm sign
Pneumomediastinum
Pneumopericardium with tamponade
Esophageal Injury
Other
* Skeletal injuries:
* Diaphragm injuries:

Radiographic Findings in Blunt Chest Trauma.ppt

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