Medical Microbiology 4th Edition Edited by Samuel Baron

Medical Microbiology
Edited by Samuel Baron
Medical Microbiology 4th Edition
Edited by Samuel Baron

Section 1. Bacteriology

1. Immunology Overview
Armond S. Goldman and Bellur S. Prabhakar.

Introduction to Bacteriology

2. Structure
Milton R.J. Salton and Kwang-Shin Kim.

3. Classification
Ellen Jo. Baron.

4. Bacterial Metabolism
Peter Jurtshuk.

5. Genetics
Randall K. Holmes and Michael G. Jobling.

6. Normal Flora
Charles Patrick. Davis.

7. Bacterial Pathogenesis
Johnny W. Peterson.

8. Specific Acquired Immunity
John B. Robbins, Rachel Schneerson, and Shousun C. Szu.

9. Epidemiology
Philip S. Brachman.

10. Principles of Diagnosis
John A. Washington.

11. Antimicrobial Chemotherapy
Harold C. Neu and Thomas D. Gootz.

12. Staphylococcus
Timothy Foster.

13. Streptococcus
Maria Jevitz. Patterson.

14. Neisseria, Moraxella, Kingella and Eikenella
Stephen A. Morse.

15. Bacillus
Peter C. B. Turnbull.

16. Miscellaneous Pathogenic Bacteria
Herbert Hof.

17. Anaerobes: General Characteristics
David J. Hentges.

18. Clostridia: Sporeforming Anaerobic Bacilli
Carol L. Wells and Tracy D. Wilkins.

19. Anaerobic Cocci
Carol L. Wells and Tracy D. Wilkins.

20. Anaerobic Gram-Negative Bacilli
Sydney M. Finegold.

21. Salmonella
Ralph A. Giannella.

22. Shigella
Thomas L. Hale and Gerald T. Keusch.

23. Campylobacter and Helicobacter
Guillermo I. Perez-Perez and Martin J. Blaser.

24. Cholera, Vibrio cholerae O1 and O139, and Other Pathogenic Vibrios
Richard A. Finkelstein.

25. Escherichia Coli in Diarrheal Disease
Doyle J. Evans and Dolores G. Evans.

26. Escherichia, Klebsiella, Enterobacter, Serratia, Citrobacter, and Proteus
M. Neal. Guentzel.

27. Pseudomonas
Barbara H. Iglewski.

28. Brucella
G.G. Alton and J.R.L. Forsyth.

29. Pasteurella, Yersinia, and Francisella
Frank M. Collins.

30. Haemophilus Species
Daniel M. Musher.

31. Bordetella
Horst Finger and Carl Heinz Wirsing. von Koenig.

32. Corynebacterium Diphtheriae
John R. Murphy.

33. Mycobacteria and Nocardia
David N. McMurray.

34. Actinomyces, Propionibacterium propionicus, and Streptomyces
Geroge H.W. Bowden.

35. Leptospira
Russell C. Johnson.

36. Treponema
Justin D. Radolf.

37. Mycoplasmas
Shmuel Razin.

38. Rickettsiae
David H. Walker.

39. Chlamydia
Yechiel Becker.

40. Legionella
Washington C. Winn.

Section 2. Virology

Introduction to Virology

41. Structure and Classification of Viruses
Hans R. Gelderblom.

42. Multiplication
Bernard Roizman.

43. Viral Genetics
W. Robert. Fleischmann.

44. Effects on Cells
Thomas Albrecht, Michael Fons, Istvan Boldogh, and Alan S. Rabson.

45. Viral Pathogenesis
Samuel Baron, Michael Fons, and Thomas Albrecht.

46. Persistent Viral Infections
Istvan Boldogh, Thomas Albrecht, and David D. Porter.

47. Tumor Viruses
Joan C. M. Macnab and David Onions.

48. Epidemiology and Evolution
Frank Fenner.

49. Nonspecific Defenses
Ferdinando Dianzani and Samuel Baron.

50. Immune Defenses
Gary R. Klimpel.

51. Control of Viral Infections and Diseases
Karen L. Goldenthal, Karen Midthun, and Kathryn C. Zoon.

52. Chemotherapy of Viral Infections
Erik De Clercq.

53. Picornaviruses
Marguerite Yin-Murphy and Jeffrey W. Almond.

54. Alphaviruses (Togaviridae) and Flaviviruses (Flaviviridae)
Alan L. Schmaljohn and David McClain.

55. Togaviruses: Rubella Virus
Paul D. Parkman.

56. Bunyaviruses
Robert E. Shope.

57. Arenaviruses
Charles J. Pfau.

58. Orthomyxoviruses
Robert B. Couch.

59. Paramyxoviruses
Gisela Enders.

60. Coronaviruses
David A.J. Tyrrell and Steven H. Myint.

61. Rhabdoviruses: Rabies Virus
Charles E. Rupprecht.

62. Human Retroviruses
Miles W. Cloyd.

63. Rotaviruses, Reoviruses, Coltiviruses, and Orbiviruses
Albert Z. Kapikian and Robert E. Shope.

64. Parvoviruses
John R. Pattison and Gary Patou.

65. Norwalk Virus and Other Caliciviruses
Neil R. Blacklow.

66. Papovaviruses
Janet S. Butel.

67. Adenoviruses
Walter Doerfler.

68. Herpesviruses
Richard J. Whitley.

69. Poxviruses
Derrick Baxby.

70. Hepatitis Viruses
Arie J. Zuckerman.

71. Subacute Spongiform Unconventional Virus Encephalopathies
Clarence J. Gibbs and David M. Asher.

72. Filoviruses
Heinz Feldmann and Hans-Dieter Klenk.

Section 3. Mycology

Introduction to Mycology

General Concepts of Mycology
Michael R. McGinnis and Stephen K. Tyring.

Introduction to Mycology
Michael R. McGinnis and Stephen K. Tyring.

73. Basic Biology of Fungi
Garry T. Cole.

74. Disease of Mechanisms of Fungi
George S. Kobayashi.

75. Spectrum of Mycoses
Thomas J. Walsh and Dennis M. Dixon.

76. Antifungal Agents
Dennis M. Dixon and Thomas J. Walsh.

Section 4. Parasitology

Introduction to Parasitology

77. Protozoa: Structure, Classification, Growth, and Development
Robert G. Yaeger.

78. Protozoa: Pathogenesis and Defenses
John Richard. Seed.

79. Intestinal Protozoa: Amebas
William A. Sodeman.

80. Other Intestinal Protozoa and Trichomonas Vaginalis
Ernest A. Meyer.

81. Free-Living Amebas: Naegleria, Acanthamoeba and Balamuthia
Augusto Julio. Martinez.

82. Hemoflagellates
Rodrigo A. Zeledón.

83. Malaria
James M. Crutcher and Stephen L. Hoffman.

84. Toxoplasma Gondii
J. P. Dubey.

85. Pneumocystis Carinii
Walter T. Hughes.

86. Helminths: Structure, Classification, Growth, and Development
Gilbert A. Castro.

87. Helminths: Pathogenesis and Defenses
Derek Wakelin.

88. Schistosomes and Other Trematodes
Barbara L. Doughty.

89. Cestodes
Donald Heyneman.

90. Enteric Nematodes of Humans
John H. Cross.

91. Enteric Nematodes of Lower Animals Transmitted to Humans: Zoonoses
Doris S. Kelsey.

92. Filarial Nematodes
John H. Cross.

Section 5. Introduction to Infectious Diseases

Introduction to Infectious Diseases

93. Infections of the Respiratory System
Purushothama V. Dasaraju and Chien Liu.

94. Microbiology of the Circulatory System
Lawrence L. Pelletier.

95. Microbiology of the Gastrointestinal Tract
Sherwood L. Gorbach.

96. Microbiology of the Nervous System
Richard T. Johnson.

97. Microbiology of the Genitourinary System
Allan Ross. Ronald and Michelle J. Alfa.

98. Microbial Infections of Skin and Nails
Raza Aly.

99. Microbiology of Dental Decay and Periodontal Disease
Walter J. Loesche.

100. Bone, Joint, and Necrotizing Soft Tissue Infections
Jon T. Mader and Jason Calhoun.


Read on line from pubmed

Read more...

Lumbar Puncture Video

Lumbar Puncture Video from Wake Forest University Schools of Medicine.
Download / view the following full-length video or individual chapters from the links below


To Download: Rt. Click Icon then Save Target as..
To View: Left Click

Indications & Contraindications 1:22
Risks & Complications 2:19
Equipment & Supplies 1:38
Review of Anatomy 2:09

Positioning the Patient 2:20

Finding the Target (injection) Point 1:58
Numbing the Target Area 1:10
Inserting the LP Needle 1:26
Collecting CSF Samples & Finishing Procedure 1:45
Administering Intrathecal Chemotherapy 0:36
Dealing with Problems 2:56
Proper Handling of CSF Samples 1:12
Interpreting Results 2:54
Summary & Review 0:41
Credits 0:40

Full version - Lumbar Puncture: Step by Step 25:05

Read more...

Amenorrhea

Amenorrhea
Presentation lecture by:Jean Amoura, MD, MSc

Amenorrhea
* Primary
o Absence of menses by age 16 with normal secondary sexual characteristics
o Absence of menses by age 14 without secondary sexual development
* Secondary
o Absence of menses for 6 months in a previously menstruating female

Events of Puberty
* Thelarche (breast development)
o Requires estrogen
* Pubarche/adrenarche (pubic hair development)
o Requires androgens
* Menarche
o Requires:
o GnRH from the hypothalamus
o FSH and LH from the pituitary
o Estrogen and progesterone from the ovaries
o Normal outflow tract

Are there secondary sexual characteristics?

Primary Amenorrhea
Think hypogonadism or hypogonadotropism
Amenorrhea with Immature Secondary Characteristics
FSH Serum level Low / normal / High
Hypogonadotropic
hypogonadism
Gonadal
dysgenesis

* Hypogonadism
* Enzyme deficiencies
* Kallmann’s syndrome, CNS tumors
* Irradiation
* Chemotherapy
* Galactosemia
* Hypogonadism (gonadal failure)
* Note: gonadotropins (FSH/LH) will be high, similar to menopause

Gonadal Dysgenesis
* Chromosomally abnormal
- Classic turner’s syndrome (45XO)
- Turner variants (45XO/46XX),(46X-abnormal X)
- Mixed gonadal dygenesis (45XO/46XY)
* Chromosomally normal
- 46XX (Pure gonadal dysgeneis)
- 46XY (Swyer’s syndrome)

Primary Amenorrhea with Immature Sexual Characteristics

* Hypogonadotropism
o Hypothalamic dysfunction
+ Kallmann syndrome
+ Anorexia nervosa
+ Space-occupying lesion of CNS
+ Marijuana use
o Pituitary damage (surgery/radiation)
o Constitutional delay

Are there secondary sexual characteristics?
* Is there normal development of secondary sexual characteristics?
* Think
o Pregnancy
o Mullerian anomaly
o Androgen insensitivity
* Mullerian Anomalies
o Mullerian agenesis (Mayer-Rokitansky-Kuster-Hauser syndrome)
o Imperforate hymen
o Transverse vaginal septum

Mayer-Rokitansky-Kuster-Hauser Syndrome (utero-vaginal agenesis)
* 15% of primary amenorrhea
* Normal secondary development & external female genitalia
* Normal female range testosterone level
* Absent uterus and upper vagina & normal ovaries
* Karyotype 46-XX
* 15-30% renal, skeletal and middle ear anomalies

Imperforate Hymen
Androgen Insensitivity
* Normal breasts but no sexual hair
* Normal looking female external genitalia
* Absent uterus and upper vagina
* Karyotype 46, XY
* Male range testosterone level
* Treatment : gonadectomy after puberty + HRT
* Evaluation
o Pregnancy test
o Physical exam to determine presence of uterus
o FSH
o Karyotype

Primary Amenorrhea
Secondary Amenorrhea
* Pregnancy!
* CNS disorders
* Pituitary gland
* Thyroid
* Ovary
* Uterus
* Systemic disorders
* CNS disorders
* Pituitary disorders
* Thyroid disorders
* Ovulation disorders
* Uterine abnormalities
* Drug-induced amenorrhea

Asherman’s Syndrome
Secondary Amenorrhea
Negative Pregnancy.test
TSH ,PROLACTIN, Progesterone challenge test
withdrawal bleeding
without withdrawal bleeding
hypoestrogenic
compromised outflow tract
* Treatment goals
* Sexually active, using condoms
* No recent change in weight, skin, hair
* Occasional heat intolerance
* No cyclic pain
* No gynecologic surgery
* Regular menses (every 28-30 days) prior to past year

* Exam
o Overweight
o No galactorrhea
o Normal hair distribution
o Normal pelvic exam
* Pregnancy test
* Progestin challenge, TSH, serum prolactin
* Estrogen/progestin cycle, FSH

Amenorrhea.ppt

Read more...