10 May 2009

Tinnitus



Tinnitus
Presenatation by:Lianne Beck, MD
Assistant Professor
Emory Family Medicine

Tinnitus
* Definition
* Classification
* Objective tinnitus
* Subjective tinnitus
* Theories
* Evaluation
* Treatment

Introduction
* Tinnitus -“The perception of sound in the absence of external stimuli.”
* Tinnire – means “ringing” in Latin
* Includes buzzing, hissing, roaring, clicking, pulsatile sounds
* For some, an unbearable sound that drives them to contemplate suicide.
* May be perceived as unilateral or bilateral
* Originating in the ears or around the head
* First or only symptom of a disease process or auditory/psychological annoyance

Classification

* Objective tinnitus – sound produced by paraauditory structures which may be heard by an examiner, often pulsatile
* Subjective tinnitus – sound is only perceived by the patient (most common)
* Pulsatile tinnitus – matches pulse or a rushing sound
o Possible vascular etiology
o Objective or subjective
o Increased or turbulent blood flow through paraauditory structures

Objective tinnitus
* Vascular (pulsatile)
o A/V malformations
o Vascular tumors
o Venous hum (cardiac murmurs, anemia, BIH, thyrotoxicosis, pregnancy, dehiscent jugular bulb)
o Atherosclerosis
o Ectopic carotid artery
o Persistent stapedial artery
o Vascular loops
* Neuromuscular
o Palatomyclonus
o Stapedial muscle spasm
* Patulous eustachian tube

Arteriovenous Malformations

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Hematuria



Hematuria

Gross hematuria:
Suspected if a red or brown color change of urine
Intermittent red or brown color urine a/w variety of clinical setting
Medications (phenazopyridine, microbid, NSAID)
Ingestion of beets or certain dyes
Metabolities
Myoglobinuria or hemoglobinuria

Work up
Centrifuge the specimen, Supernatant be tested for heme (hemoglobin or myoglobin) with a urine dipstick.

Causes of heme-negative red urine
Medications
Food dyes
Metabolities
Doxorubicin
Beets (in selected patients)
Bile pigments
Chloroquine
Blackberries
Homogentisic acid
Deferoxamine
Food coloring
Melanin
Ibuprofen
Methemoglobin
Iron sorbitol
Porphyrin
Nitrofurantoin
Tyrosinosis
Phenazopyridine
Urates
Phenolphthalein
Rifampin

Approach to the patient with red or brown urine
Microscopic hematuria:
Major causes of hematuria by age and duration
The evaluation should address the following three questions

1. Are there any clues from the history or physical examination that suggest a particular diagnosis?
2. Does the hematuria represent glomerular or extraglomerular bleeding?
3. Is the hematuria transient or persistent?

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Insulin Secretion, Beta Cell Biology



Insulin Secretion, Beta Cell Biology and the Pathogenesis of Type 2 Diabetes


Kenneth S. Polonsky
Presentation by:Professor of Medicine, Cell Biology and Physiology
Director Institute of Clinical and Translational Sciences
Washington University School of Medicine

Diabetes:Basic Abnormalities
Islets of Langerhans
GLUCOSE
Pancreas
Muscle
Liver
Fat

INSULIN
* The pancreas does not produce enough insulin
* Muscle, liver and fat tissues don’t respond to insulin-insulin resistance
* Elevated Fatty Acids impair insulin secretion and action

Normal Glucose Tolerance
Genetic susceptibility
Diabetogenic Lifestyle
Normal Glucose Tolerance
Insulin Resistance
Compensatory hypersecretion of insulin
Impaired Glucose Tolerance
Insulin Resistance
β-cell compensation starts to fail
Overt Hyperglycemia
Insulin Resistance
Failed β-cell compensation

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