27 April 2009

Kawasaki Syndrome



Kawasaki Syndrome
Presentation by: Anna Mae Smith, MPAS, PA-C
Lock Haven University

* An acute, distinct, self-limited, febrile disease of children
o Mucocutaneous lymph node syndrome
o vasculitis of coronary blood vessels with potential dilation, aneurysms, thrombosis, rupture, or myocardial ischemia
o 25% develop cardiac sequelae
* Incidence/Prevalence in USA: Worldwide, affects all races but most prevalent in Japan
* In the US, the annual incidence rate is 0.6 cases/100,000 children under 5 years old
* Seasonal variation - increased in winter and spring.
* Increased outbreaks at 2-3 year intervals
* Predominant age: 1-5 years; 50% are < 2 years old, 80% are < 5 years old. Seldom
* seen after 8 years of age

Diagnostic Criteria

* Fever lasting greater than 5 days plus 4 of the 5 following…
o Polymorphous rash
o Bilat. Conjunctiva injection
o 1 or more mucous mb changes
+ Diffuse injection of oral/pharyngeal mucosa
+ Erythema or fissure of the lips
+ Strawberry tongue
o Acute cervical lymphadenopathy
o 1 or more extremity changes
+ Erythema of palms &/or soles
+ Indurative edema of the same
+ Membranous desquamation of the fingertips
Treatment

TAKAYASU ARTERITIS

* Asian population
* Affects young adult populations
* Affects large elastic arteries
o Aorta & major branches & renal

ALLERGIC ANGIITIS/CHURG- STRAUSS SYNDROME

* Occurs in patients with asthma
* Middle age men>women
* Eosinophilia >10% WBC
* Mono or Polyneuropathy
* Transitory Pulmonary infiltrates
* Paranasal sinus Abnormalities
* Biopsy - Extravascular eosinophils

Kawasaki Syndrome

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Patient Management Strategies in Arthritis



Patient Management Strategies in Arthritis
Presented by: Anna Mae Smith, MPAS, PA-C
Lock Haven University of PA


Physician Assistant Program
DJD/Osteoarthritis

* Obesity
o increase in body mass
o altered biodynamics of gait
o genetic predisposition (genetically obese mice are susceptible to osteoarthritis)
o altered metabolism (e.g., estrogens)
Risk Factors

* Occupational
Treatment

* Physical measures may be subdivided into..
o Exercise
o Supportive devices
o Alterations in activities of daily living
o Thermal modalities
Exercise

* Associated with reduced pain & improved function.
o Passive range of motion
o Rest periods
o Active: range of motion, isometric, isotonic, isokinetic
* Improved muscle tone reduces muscle spasm and prevents contractures. It is theorized that improved muscle support of the joint will retard the progression of osteoarthritis.

Which Exercises
* Swimming
* Biking (Stationary)
* Walking

Support Devices & Orhotics

* Devices such as canes, forearm crutches, crutches, and walkers can improve balance and decrease pain.
* The total length of a properly measured cane should be equal to the distance between the upper border of the greater trochanter of the femur and the bottom of the heel of the shoe. This should result in elbow flexion of about 20°.
* The cane should be held in the hand contralateral to and moved together with the affected limb. The healthier limb should precede the affected limb when climbing up stairs; when climbing down stairs, the cane and the affected limb should be advanced first. The cane can unload the affected hip by 60%.

Modified activities of daily living
* Proper positioning and support when sitting, sleeping or driving a car
* Adjusting ways of performing such activities as getting dressed, etc.
* Adjusting furnishings around the house or at work (e.g., raising the level of a chair or toilet seat)

Thermal modalities
* Superficial heat (e.g., hot packs, paraffin baths)
* Deep heat (e.g., ultrasound)
* Cold applications (e.g., cold packs, vapocoolant sprays)

HEAT

* The therapeutic value of applying heat includes decreasing joint stiffness, alleviating pain, relieving muscle spasm, and preventing contractures.
* The use of heat is contraindicated over tissues with inadequate vascular supply, bleeding, or cancer. Heat should also be avoided in areas close to the testicles or near developing fetuses.

Miscellaneous

* Pulsed electromagnetic fields
* TENS
* Acupuncture
* Chiropractic
* Spa, massage, and yoga therapy


Short acting drugs
Long Acting Agents
Hyaluronic Acid Derivatives
DIET

* Avoid coffee, artificial additives, red meats & processed foods
* Limit tomatoes,potatoes,eggplants, peppers, & simple carbohydrates(white flour & refined sugar).
* Fresh fruits & veges, complex carbs, wheat germ & oily fish
* Vit. A 10,000iu/day
* Vit. C 2grams/day
* Vit. E 600iu/day
* Vit. B6 50 mg/day

First-line therapy

* Anti-inflammatories
* Aspirin
* Nonsteroidal anti-inflammatory
Second Line Therapies

* Antimalarials (chloroquine, hydroxychloroquine)
* Sulfasalazine
* Methotrexate
* Gold salts
* Auranofin
* Parenteral gold
* D-penicillamine
* Azathioprine
* Cyclosporin A
* Combination therapies
* Corticosteroids
* Systemic steroids
* Low-dose oral
* Parenteral pulse steroids
* Intra-articular

Investigational

* EPA (eicosapentaenoic) - anti-inflammatory effect of fish oil fatty acid
* Plant seed oils particularly those extracted from evening primrose oil and borage seed oil that contain large amounts of gamma linolenic acid.
Light Therapy

* Extracorporeal photochemotherapy and extracorporeal protein A immunoadsorption
Vitamins

* Vit. C 2grams/day
* Vit. E 600iu/day
* B complex vitamin
* Calcium 1200-1500/day
* Selenium 100mg/day
* Zinc 30mg/day

Hydrotherapy

* Cold compresses when acutely inflamed followed by alternating hot & cold
* Massage - lavender, tiger balm & chamomile oils

Herbs

* Black cohosh
* Wild yam
* Willow bark
* Licorice

Patient Management Strategies in Arthritis.ppt

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Patient Management Strategies in Fibromyalgia



Patient Management Strategies in Fibromyalgia
Presentation by: Anna Mae Smith,MPAS, PA-C
Lock Haven University of PA

Education

* Not a ‘psychiatric’ illness
* Usually chronic but controllable
* Not deforming or Life-threatening
* Medications that improve sleep appear to be the best treatment!

Amitriptyline & Cyclobenzaprine

* They tend to increase NREM Stage IV sleep
* the availability of brain serotonin
* decrease muscle spasm
* Decreases patients' reports of pain intensity
* Sleep quality
* Improvements in pain threshold or tender point counts
* Loses effect after 6 months

Alprazolam and ibuprofen
Other Treatments

* Aerobic Exercise
* Cognitive Behavior Therapy
* Biofeedback
* Hypnotherapy
* Acupuncture
* Inject trigger points with steroids
* Treat underlying depression if needed

Diet
* avoid the following:
* refined sugar
* alcohol
* caffeine
* foods high in saturated fats
* high-calorie, high-fat, low-food-value junk food
* A moderate diet containing the following ratio (based on percentages of calories, not grams):
40% carbohydrate/ 30% protein/ 30% fat for each meal and snack
* Water…8/8oz

Herbs

* Ginseng and gotu kola, have both been found to improve energy and mental alertness.
* Ginseng is known to contain a steroid
* Valerian Root
* St John’s Wort
* Gingko Biloba
* Grape See Extract
* Devils Claw Root

Patient Management Strategies in Fibromyalgia.ppt

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