Ion Channels in the Cardiovascular System in Health and Disease

Ion Channels in the Cardiovascular System in Health and Disease
Presentation by: William A. Coetzee

Hearts are Composed of Cells
The Cardiac Myocyte
Cells Have Membranes
Patch Clamping
Ion Channels - Gating
Inward Currents
Outward Currents
Ion Channels

* Na+ channels
* Ca2+ channels
* K+ channels
* Exchangers
* Pumps

Na+-Channels: Genetic Disorders
Na+ Channels - Pharmacology
Ca2+ Channels: Electrophysiology
Ca2+ Channel a-Subunits
Molecular Composition
Ca2+ Channel a-Subunits
Structural elements of function
Hyperkalemic periodic paralysis
Malignant hyperthermia
Functional Diversity of K+ Channels in the Heart
Voltage-activated K+ Channels
Inward Rectifier K+ Channels
Leak K+ Channels
Plateau (IKP) K+ channels
K+ Channels - Structure
K+ Channel Principal and Auxiliary Subunits
Voltage-gated K+ channels
Ca2+-activated K+ channels
Voltage-activated K+ Channels
Transient Outward K+ Channels
Delayed Rectifier Currents
Two Types of Delayed Rectifiers
Compounds Blocking Delayed Rectifiers
K+ Channel a-Subunits
Molecular determinants of gating
N-type inactivation
Kvb Subunits Accelerate Inactivation of Kv Channels
Enhanced Surface Expression
Kvb Subunits as Molecular Chaperones
3-Dimensional Structure of Kvb2
Kvb Confers Hypoxia-Sensitivity to Kv4 Channels
Identification of Frequenin as a Putative Kv4 b-subunit
Effects of Frequenin on Kv4.2 Currents
Delayed Rectifier K+ Channels
Molecular Composition
Voltage-activated K+ Channels Pharmacology
Mechanisms of Arrhythmias
Triggered Activity
Early Afterdepolarizations
Factors Promoting EADs
Inward Rectifier K+ Channels
Voltage-activated
Inward Rectifier K+ Channels
Electrophysiology
K+ Channel Principal Subunits
Voltage-gated K+ channels
Ca2+-activated K+ channels
K+ Channel Principal and Auxiliary Subunits
Voltage-gated K+ channels
Ca2+-activated K+ channels
Inward Rectifier K+ Channels
Genetic Disorders
Bartter’s syndrome
K+ Channel Principal and Auxiliary Subunits
Role of the KATP Channel
Secretory Mechanisms
Mechanism of Insulin Release
Glibenclamide Blocks KATP Channels

Ion Channels in the Cardiovascular System in Health and Disease.ppt

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Receptor theory

Receptor theory

Presentation covered the following topics.
Nerve/Muscle Endings
Muscle Fiber
Intercellular Signaling
Criteria for hormone-mediated events
Recognition and Transduction
Receptor theory and receptor binding.
Scatchard transformation
Competition binding assays
Dose-response experiments.
Fractional response
Receptor antagonists.
Competitive antagonist.
Non-competitive antagonist
Irreversible antagonists.
Receptor subtypes
Opioid receptor subtypes
Receptor type
Selective antagonists
CTAP
Stopping the GPCR signal
Receptor desensitization
Receptor down-regulation

Receptor theory.ppt

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New Antiepileptic Drugs and Treatments

New Antiepileptic Drugs and Treatments
Presentation by: Josiane LaJoie, MD

Assistant Professor of Neurology and Pediatrics
NYU Comprehensive Epilepsy Center
New AED’s
Gabapentin
Gabapentin Side Effects
FELBAMATE
FBM Dosing
FBM-Common Side Effects
Aplastic Anemia and Hepatotoxicity with Felbamate
Risks of Felbamate
Fatal Hepatotoxicity of VPA
FBM Interactions
LAMOTRIGINE
Lamotrigine Side Effects
Lamictal and SJS
Lamictal Dosing-Children
Lamotrigine and AED’s
Topiramate
Topiramate SE
Topiramate Interactions
TIAGABINE
Tiagabine Dosing
Tiagabine Side Effects
Tiagabine Interactions
Levetiracetam
Zonisamide
New Treatments
Vagus Nerve Stimulator (VNS)
VNS candidates
VNS Implantation
The VNS System
VNS Function
Effects & Side Effects
Deep Brain Stimulation
Cerebellar Stimulation
Brain Stimulation
Functional Radiosurgery
Gamma Knife-Limitations
Neuropace
Melatonin
Melatonin’s Effects
Evidence-Basic Science
Animal study
Evidence-Clinical Studies

New Antiepileptic Drugs and Treatments.ppt

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Drug Induced Liver Injury

Drug Induced Liver Injury
Presentation by:Robert J. Fontana, MD
University of Michigan Medical Center

Drug Induced Liver Injury
Hepatic Adverse Event Nomenclature
Liver Injury Classification
DILI Population based study
DILI Diagnosis
Clinicopathologic forms of DILI
DILI: A Diagnosis of exclusion
Acute Hepatocellular: Differential Dx
Ultrasound/ CT
DILI: Causality Assessment
RUCAM
RUCAM limitations
Prognosis in DILI with jaundice
Spectrum of DILI
ALT monitoring and DILI
DILI pathogenesis
DILIN: Sphere of Influence
Idiosyncratic Liver Injury Associated with Drugs (ILIAD)
New agent signals
Drug
Human genome
DILIN Genotyping Initiative
Acetaminophen: Friend or foe ?
Glucuronyl transferases sulfotransferases
Acetaminophen
ACM-cysteine adducts
Biomarker for ACM hepatotoxicity
Implications of ACM related ALF
Acetaminophen advice
Acetaminophen toxicity in severe acute HAV/ HBV
Prospective Study Design
DILI Causality Instrument
Prognosis in DILI with jaundice

Drug Induced Liver Injury.ppt

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Neuropsychopharmacology

Neuropsychopharmacology

Free access prior to 12 months from current.

Neuropsychopharmacology is an international scientific journal and the official publication of the American College of Neuropsychopharmacology. The journal focuses on clinical and basic science contributions that advance our understanding of the brain and behaviour.

Access from 1994 Volume 11, issue 3 onwards
narure.com

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