Showing posts with label Immunology. Show all posts
Showing posts with label Immunology. Show all posts

14 October 2012

Antigen Antibody Reactions



Antigen-Antibody Reactions
Robert J. Boackle, Ph.D.
http://www.musc.edu

Antigen-Antibody interactions
http://www.longwood.edu/

Antigen-Antibody Interactions
http://www3.uwsuper.edu

Common Methods of protein detection
http://vet.tufts.edu

Advanced Clinical Immunohematology
Antigen and Antibody Reactions
http://colleges.weber.edu

Antigen-Antibody Interactions
http://www.uvm.edu

Antigen-Antibody Interactions
Dr. Capers
http://faculty.irsc.edu

Antibody-Antigen Reactions
http://www.umich.edu

The Immune Response: Antigen-Antibody Reactions
http://pages.cabrini.edu

Radioimmunoassay & Enzyme Linked Immunosorbent Assay
M K Unnikrishnan
http://www.pitt.edu

Antibody Detection
Renee Wilkins, PhD, MLS(ASCP)cm
http://cls.umc.edu/


Use of Antigen-Antibody Reactions in Lab
http://web.biosci.utexas.edu

Blood, Lymph and Immune Systems
http://www.rsu.edu

Antibody Identification
http://colleges.weber.edu

Practical Applications of Immunology
http://www.austincc.edu/

Blood Group Antigens and Antibodies
Terry Kotrla, MS, MT(ASCP)BB
http://www.austincc.edu

Basic Immunologic Procedures
Terry Kotrla, MS, MT(ASCP)BB
http://www.austincc.edu

237 Published articles on Antigen Antibody Reactions

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21 July 2012

IPEX Syndrome



IPEX Syndrome
Immunodysregulation Polyendocrinopathy Enteropathy X-linked Syndrome is a rare disease linked to the dysfunction of the transcriptional activator.
Child with IPEX syndrome
http://som.ucdenver.edu/
Diabetes in Youth
http://www.ucdenver.edu

Cells of the Immune System
http://www.med.umich.edu/

T Regulatory Cells and Stem Cell Transplantation
Armin Ghobadi, MD
http://hematology.im.wustl.edu

Type 4 Hypersensitivity and Autoimmunity
http://web.ics.purdue.edu

Type 1 Diabetes
Mark Anderson, MD,PhD
http://physio.ucsf.edu

Immune Tolerance
Dr. Prakash Nagarkatti
http://pathmicro.med.sc.edu

Regulatory T cells, or Tregs
http://bmdcr.bsd.uchicago.edu

IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome)
http://www.sbs.utexas.edu/

Immune system
http://www.sbs.utexas.edu/

Disruption of Healthy Tissue by the Immune Response
http://ww2.madonna.edu

Regulatory T Cells
M. Carrie Miceli
http://www.lsic.ucla.edu/

Immunology: Gene Expression and Natural Defense Systems
http://faculty.irsc.edu
58 Published articles on IPEX Syndrome

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09 July 2012

Systemic Lupus Erythematosus (SLE)



Systemic Lupus Erythematosus
Steve Beesley
http://ruby.fgcu.edu/

Systemic Lupus Erythematosus
http://isites.harvard.edu/

Systemic Lupus Erythematosus (SLE)
Heidi Roppelt, MD
https://cbase.som.sunysb.edu/

Systemic Lupus Erythematosus
Cassidy Summers, Tricia Molett, Summer Lashley, Kelly Winship
http://mailer.fsu.edu

Systemic Lupus Erythematosus (SLE)
http://www.austincc.edu/

Lupus
http://sest.vsu.edu/

SLE: Fighting Self Sabotage
Susan Manzi, MD, MPH
http://www.pitt.edu

Autoimmune diseases
Henry O. Ogedegbe, PhD., C(ASCP)SC
http://ruby.fgcu.edu

What’s New in Lupus
Jennifer H. Anolik, MD, PhD
http://www.urmc.rochester.edu

Emergency Issues in Pediatric Rheumatology
Elivette Zambrana-Flores
http://www.pediatrics.emory.edu

Neuropsychiatric Lupus
SEULI BOSE BRILL, MD
https://medicine.med.unc.edu/


Latest 200 full text articles free access

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02 July 2012

Rh Isoimmunization



Post Partum Mother
http://www.oakton.edu/

Isoimmunization
http://faculty.msmc.edu/

The pregnant trauma patient
Tom Archer MD, MBA
http://anes-som.ucsd.edu/

Reproductive Life Planning
Becca Maddox
http://www.highlands.edu/

Objectives for Medical Students Isoimmunization
http://www.med.unc.edu/

Rh isoimmunization
http://cstl-hhs.semo.edu

Isoimmunization
http://pediatrics.uchicago.edu

Human Reproduction
http://www.ansci.wisc.edu/

Care of the Client Experiencing Dysfunctional Childbirth
T. Dennis
http://www.abac.edu

Assessment of Fetal Well Being
http://www.lavc.edu/

Diagnostic Tests
Prof. Unn Hidle
http://faculty.lagcc.cuny.edu/

Hyperbilirubinemia
http://www.ohsu.edu

Assessment of Fetal Well Being
http://www.mccc.edu

Indications For Emergency CS
http://elearning.najah.edu

The Newborn at Risk: Acquired and Congenital Problems
http://www.sonoma.edu

Medical Complications of Pregnancy
Serena Wu, MD
http://www.unmc.edu

Complications During Pregnancy
http://www.netc.edu/

Alloimmunization in Pregnancy
Brooke Grizzell, M.D.
http://www.austincc.edu

High Risk Newborn
Mary L. Dunlap
http://www.lscc.edu/


48 free access published articles

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05 June 2012

Immunosuppressants



Immunosuppression in Bone Marrow Transplant
Ashley Newland, PharmD
BMT_2011.ppt

Immunosuppression for Cardiac Transplantation
Immunosuppression.ppt

Transplant Associated Thrombotic Microangiopathy (TA-TMA)
Kristen Sanfilippo MD
Transplant Associated Thrombotic Microangiopathy.ppt

Agents Which Affect the Immune Response
Dan Fernandez
Agents Which Affect the Immune Response.ppt

Immunosuppressants
Immunosuppressants.ppt

Care of the Post-OLT Patient
George Makar
CareofthePostOLTPatient.ppt

Dermatology
Pediatrics/Dermatology.ppt

Eczema Atopic Dermatitis
Eczema Atopic Dermatitis.ppt

Introduction to Transplantation  Immunosuppression
Transplantation  Immunosuppression.ppt

Organ Transplant and Recovery 
K. Brooks, RN, MSNEd
Organ Transplant and Recovery .ppt

Transplantation Immunology
Mitchell S. Cairo, MD
Transplantation Immunology.ppt

Hypersensitivity Disorders
Hypersensitivity Disorders.ppt

Thrombotic Microangiopathy after Stem Cell Transplant
Janakiraman Subramanian M.D.
Thrombotic Microangiopathy after Stem Cell Transplant.ppt

Chronic GVHD: in Search of a Model to Understand its Pathobiology
Mark A. Schroeder, M.D.
Chronic GVHD.ppt

Post PCI Contrast Induced Nephropathy
Brandon M. Williams M.D
Post PCI Contrast Induced Nephropathy.ppt

Calcium entry and calcium signaling – different routes, different roles
Calcium entry and calcium signaling.ppt

Atopic Dermatitis
Nnenna G. Agim, MD
Atopic Dermatitis.ppt

Drugs in the Therapy of Transplant Rejection
Dr. Thomas Abraham
ImmunosuppressiveAgents.ppt

Principles of Pharmacology Immunomodulators
Dr. Laure Aurelian
Principles of Pharmacology Immunomodulators.ppt

Care of Clients with Altered Immunity
Care of Clients with Altered Immunity.ppt
467 Published articles list

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24 May 2012

Humoral Immunity



The term humoral refers to the non-cellular components of the blood, such as plasma and lymphatic fluid. The humoral immune response denotes immunologic responses that are mediated by antibodies.

Humoral Immunity
Humoral Immunity.ppt

Humoral Immunity Antibodies
Humoral Immunity Antibodies.ppt

Humoral Immune Response
Terry Kotrla, MS, MT(ASCP)BB
HumoralImmuneResponse.ppt
HumoralImmuneResponseFall2010.ppt

Effector Mechanisms of Humoral Immunity
Effector Mechanisms of Humoral Immunity.ppt

Immunity mediated by B-lymphocytes and Antibodies
Immunity mediated by B-lymphocytes and Antibodies.ppt

The Immune System: Innate and Adaptive Body Defenses
The Immune System.ppt

The Immune system
The Immune System.ppt

Adaptive/Acquired Immunity
Adaptive_Immunity2.ppt

Specific Host Defenses: The Immune Response
SpecificDefenses.ppt

The Body’s Defenses
Immunity.ppt

Acquired – Specific – Adaptive Immunity
Acquired – Specific – Adaptive Immunity.ppt

Immunity Body Defenses
ImmunityF07.ppt

Immune System
Daryl Beatty
Immune System.ppt

DNA Vaccines
DNA Vaccines.ppt

Adaptive Immunity: Specific Defenses of the Host
Adaptive Immunity.ppt

Immunity and Cell Defense
Lukasz Stelinski
Immunity and Cell Defense.ppt

Humoral Immune Response
Humoral Immune Response.ppt

Adaptive Immune Response
Adaptive Immune Response.ppt

The Immune System
immune.ppt

Immunity and Autoimmune Disease
Jessica Rando
Immunologyfinal.ppt

Immune Response and Immunity
Mark D. Sobsey
Immune Response and Immunity.ppt

Humoral Immunity: B Cells
SpecificResistII.ppt

Immunity – The War Against Infection
Immunity – The War Against Infection.ppt

Lymphatics and the Immune System
Lymphatics and the Immune System.ppt
Published articles on humoral immunity Free access

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06 May 2012

Wiskott-Aldrich Syndrome



The Wiskott-Aldrich Syndrome: An X-linked Primary Immunodeficiency
Kristin Goff
The Wiskott-Aldrich Syndrome.ppt

Wiskott Aldrich Syndrome Treatment
The Wiskott-Aldrich Syndrome.ppt

Immunodeficiency
Immunodeficiency.ppt

Primary Immunodeficiency
Regina D. Wells, MD
Immune_System_for_the_Boards.ppt

Wiskott-Aldrich Syndrome (WAS)
Wiskott-Aldrich Syndrome (WAS).ppt

Transfusion Associated Graft versus Host Disease TAGvHD
Lloyd O. Cook, M.D.
TransfusionAssociatedGraftversusHostDisease.ppt

Immunodeficiencies
Immunodeficiencies.ppt

Protein Ontologies and Protein Disorder
A. Keith Dunker
Protein Ontologies and Protein Disorder.ppt

Heme-Onc Grand Rounds Case Presentation
Case Presentation.ppt

Clinical Coagulation
QualPLTs.ppt

Atopic Dermatitis, Eczema, and Noninfectious Immunodeficiency Disorders
Atopic Dermatitis.ppt

Platelet structure
Platelet structure disorders.ppt
200 scholarly articles free access

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16 April 2012

Cytokines Ppts and 100 free full text articles



Cytokines
Cytokines.ppt

Cytokines and Chemokines
Leo Carr
Cytokines.ppt

Cytokines and Receptors
Cytokines.ppt

Cytokines and Thelper subsets
Cytokines and Thelper subsets.ppt

Principles of Immunology Cytokines
Cytokines.ppt

Cytokines Functions Receptors Signalling
Cytokines Functions Receptors Signalling.ppt

Cytokines-Based Diseases and Cytokine Therapy
Cytokine.ppt

Cytokines and the regulation of steroid genesis
Buck Hales
Cytokines.ppt

Cytokines and Chemokines
Immuno.Cytokines.ppt

Cytokines Molecular Signals
Immunology/Cytokines.ppt

Cytokines properties, categories, signalling, function
Signalling.ppt
100 free full text articles

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24 March 2010

Immune System Overview Mechanisms of Immunosuppression



Immune System Overview Mechanisms of Immunosuppression
By:Bob Luebke
Immunotoxicology Branch
Experimental Toxicology Division
NHEERL, ORD

Role of the Immune System in Homeostasis

* Bidirectional interaction with other systems
o Reproduction
o Endocrine
o CNS

Basics of Immunology
The Immune Response
Innate Immunity
Adaptive (Acquired) Immunity
-Phylogenetically ancient
-Limited recognition
-Rapid (minutes – hours)
- No cell proliferation required
-Limited memory (? mammals)
-First appeared in jawed fishes
- Infinite array of specificities
- Slow (days)
-Requires proliferation and differentiation
-Long-lasting memory

Basics of Immunology
* The adaptive immune response to antigen
Organs of the Immune System
Immune System Anatomy
Organs of the Immune System
Thymus: source of naive T cells
Fate of T Cells in the Thymus
Positive selection: optimal binding to self Ag prevents apoptosis
Negative selection: superoptimal binding to self Ag induces apoptosis
B cells: Tolerance to “Self”
Anergy: low expression of
IgM on surface; can’t bind Ag
Clonal ignorance: too few
copies of Ag in the periphery

Thymus size and architecture:
* May be very sensitive to xenobiotics
* Also sensitive to acute toxicity

Methods for Assessing Direct Immunotoxicity Associated with Exposure to Chemicals
Organs of the Immune System
Spleen: Antigen trapping and presentation, clonal expansion, cellular export
Organs of the Immune System
Lymph nodes: Antigen trapping and presentation, clonal expansion, cellular export
Cells of the Immune System
Innate Immune System: Granulocytes
Neutrophil (“PMN”)
* First responders
* Phagocytosis and killing of bacteria
* Inflammation

Eosinophil
* Allergy
* Killing parasite larvae
Basophil
* Circulating mast cells
* Allergy/anaphylaxis

Innate Immune System: Granulocytes
Neutrophil (“PMN”)
* First responders
* Phagocytosis and killing of bacteria
* Inflammation
Cells of the Immune System
Innate Immune System: Monocytes
Monocyte/macrophage
Macrophage with ingested
asbestos fiber (encarta.msn.com)
* Phagocytosis and killing of bacteria
* Antigen processing
* Inflammation
Adaptive Immune System: Lymphocytes
Activated B cell
Peripheral blood
Activated T cell (SEM)
* B cells: Mature into plasma cells, secrete antibody (IgM, IgG, IgA, IgE, IgD)
* T cells: T helper - produce stimulatory and regulatory cytokines
* T cells: T cytotoxic/suppressor – contact-dependent cytotoxicity,

regulation of immune response
* NK cells: direct killing of cells (innate arm of IS)

Plasma Cells Produce Antibodies
* IgM: Primary response, efficient agglutination
* IgG: Recall response, highest concentration
* IgA: Mucosal surfaces, trapping of microbes
* IgE: Allery/anaphylaxis

Factors Affecting Immunocompetence
* Age
* Gender
* Genotype
* Nutritional status
* Life style choices
* Acute toxicity
CONCEPT: Individual immunocompetence, in the absence of xenobiotic exposure, is complex, dynamic and affected by fixed and variable factors. At the population level, the “normal” range is broad.

Immunocompetence in the Young: Innate immunity
* Neutrophils
* NK cells
Immunocompetence in the Young: Adaptive immunity
* Humoral immunity
* Cellular immunity
* Resistance to infection
Advanced Age and Immunocompetence

* Innate Immunity
* Adaptive immunity
* Resistance to infection

Gender and Immunocompetence
Genotype and Immunocompetence
Lifestyle and Immunocompetence
* Recreational drug use
* Excessive use of alcohol
* Smoking
* Stress

Xenobiotic Exposure and Immunocompetence
Immune
System
Exposure
Suppression
Infection
Neoplasia
Modulation
Allergy
Autoimmunity

Consequences of Xenobiotic Exposure on Immunocompetence
“Pre-immune” Mechanisms of Defense
Immune Mediated Resistance to Infection
Organism Factors Influencing Host Resistance
Mechanisms of Chemically-induced Immunosuppression
Mechanisms of Suppression:
Effects on Supply of Cells
Mechanisms of Suppression: Effects on Supply of Cells
UVB (320-280 nm) exposure
Mechanisms of Suppression: Tolerance Induction (and then some)
Mechanisms of Suppression: Tolerance Induction (human studies)
Mechanisms of Suppression: Modulation of cytokine production
Mechanisms of Suppression: Th1/Th2 Polarization
Mechanisms of Suppression: Disruption of innate immunity
Human and Mouse Macrophage Responses to Ozone in vivo
Mechanisms of Chemically-induced Immunosuppression
Mechanisms of Suppression:
Summary
* Reduced supply of immune system cells
* Misdirection of the immune system
* Direct effects on cells
* Combination of effects
Decreased Host Resistance: Implications for Human Health

Immune System Overview Mechanisms of Immunosuppression

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26 April 2009

Autoimmune Disorders



Autoimmune Disorders

Classification of Autoimmune Diseases
Local single organ
Probable:

* Hashimoto thyroidistis
* Autoimmune haemolytic anaemia
* Autoimmune atrophic gastritis (pernicious anemia)
* Autoimmune encephalomyelitis
* Autoimmune orchitis
* Goodpasture syndrome
* Autoimmune thrombocytopaenia
* Type I DM (IDDM)
* Myasthenia gravis
* Graves disease

Possible:

* Primary biliary cirrhosis
* Chronic active hepatitis
* Ulcerative colitis
* Membranous glomerulonephritis

Systemic multiple sites

Probable:

* Systemic Lupus Erythematosus
* Rheumatoid arhtritis
* Sjogren’s syndrome
* Reiter syndrome
* Inflammatory myopathy
* Systemic sclerosis (scleroderma)
* Polyarteritis nodosa

Immunological Tolerance

* State in which an individual is capable of developing an immune response against a specific antigen
* Self- tolerance specifically refers to a lack of immune responsiveness to one’s own tissue antigens
* Immunologically competent cells learn to recognize the body’s own antigens at an early stage
* Central vs peripheral tolerance

Central Tolerance
Clonal deletion
Peripheral Tolerance
Apoptosis
Peripheral suppression
Failure in Tolerance

* Failure in activation-induced cell death (apoptosis)
* Breakdown of T-cell anergy
* Bypass of B-cell requirement for T-cell help
* Failure in T-cell mediated suppression
* Polyclonal lymphocyte activation
* Release of sequestered antigens
* Exposure of cryptic self & epitope speading
* Normally maintained in isolation from immune mechanisms
* Hidden/sequestered antigens may not be recognised as self (such as intracellular substances)
* E.g spermatazoa; myelin protein; lens material



Breakdown of T-cell helper tolerace
T-cell suppressor function
Genetics
Infection
Autoimmune Disorders & Mechanisms
General Pathology
Immunological Antibodies & HLA
Rheumatoid Factor
Antinuclear Antibody
Pansma autoantibodies & Disease Association
Human Leukocyte Antigen (HLA)
HLA – B27

Autoimmune Disorders.ppt

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Forensic Serology - Immunoassays



Forensic Serology - Immunoassays

Immunoassay Definitions
Structure of Antibodies
Preparation of Polyclonal Antibodies
Preparation of Monoclonal Antibodies
Categories of Immunoassay Tests
Competitive Assays
Noncompetitive Assays
Heterogeneous and Homogeneous Immunoassays Methods
Radioimmunoassay (RIA)
Enzyme Immunoassay (EIA)
Enzyme Immunoassay (ELISA)
Fluorescence Polarization Immunoassay (FPIA)
Fluorescence
Polarized Light
Accuracy and Precision
Calibrators and Controls
Assay Interferences
Elisa is a type of EIA

Forensic Serology - Immunoassays.ppt

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Immunology and immunotherapy in allergic disease



Immunology and immunotherapy in allergic disease
Presentation by:Jing Shen , M. D.
Matthew Ryan, M. D.

Allergy
Hypersensitivity
Immunology review
Antigen presenting cells
CD4+ T lymphocyte
Cytokines
B lymphocyte and IgE antibodies
Mast cells
Eosinophil
Immunotherapy
Mechanism: B cell response
Mechanism: T cell response
Long term efficacy of immunotherapy
Advantage of immunotherapy
Patient selection
Immunotherapy
Sublingual immunotherapy

Efficacy of sublingual immunotherapy

References

Immunology and immunotherapy in allergic disease.ppt

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22 April 2009

Immunology Presentations



Introduction to Immunology
Antibody Structure and B Cell Diversity
Antigen Recognition by T Lymphocytes
Development of B Lymphocytes
Development of T Lymphocytes
T Cell Mediated Immunity (CMI)
Immunity Mediated by B Cells and Antibodies
Defense Mechanisms of Human Host
Failure of Human Defense Mechanisms
HIV Infection and AIDS
Allergy and Hypersensitivity
Autoimmunity and Autoimmune Diseases
Case Studies in Autoimmunity
Case Studies in Autoimmunity
Multiple Sclerosis
Myasthenia Gravis
Vaccines and Vaccination
Transplantation of Tissue and Organs

Read more...
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