Selective Estrogen Receptor Modulators

Selective Estrogen Receptor Modulators
Steroid Hormone Receptor Signaling
http://www.sbs.utexas.edu

Estrogen Receptor: New Paradigms in Localization, Function,
Constitution, Signaling and related SERMs Strategies.
Irida Kastrati
http://lab.pharm.uic.edu

Estrogen receptor alpha
Colette N. Miller, MS
http://cnmiller.myweb.uga.edu/

Selective Estrogen Receptor Modulators Cause Abnormal Skeletal Development in the Zebrafish
Joshua Simulcik
http://www.staff.sbc.edu

Steroid/Intracellular Receptor Pharmacology
https://courses.washington.edu

Idoxifene: A Selective Estrogen Receptor Modulator that Prevents Bone Loss in Ovariectomized rats
Nuttall, M., Bradbeer, J.N., Stroup, G.B., Nadeau, D.P., Hoffman, S.J., Zhao, H., Rehm, S., and Gowen, M.
http://snhs-plin.barry.edu

Endometrial Cancer
Faina Linkov, PhD
http://www.pitt.edu

Estrogens and Progestins: Basic Pharmacology and Noncontraceptive Applications
http://www.epcc.edu

Sex Hormones and Drugs
http://www.calstatela.edu

Breast Cancer Chemoprevention
Jane Chawla, M.D.
http://hematology.wustl.edu

Selective Estrogen Receptor Modulators (SERMS)
http://www.siumed.edu

Steroid Hormones
Estrogen & Progesterone
http://faculty.smu.edu

Estrogens, Progestins, & Hormone Therapy
Lorelei Vandiver
http://faculty.smu.edu

Estrogen Antagonists/SERMs
http://faculty.smu.edu

Gonadal hormones
http://elearning.najah.edu

Osteoporosis
http://www.med.unc.edu

Published articles
1. Güerri-Fernández RC, Diez-Perez A. Is there a future for selective - estrogen-receptor modulators in osteoporosis? Ther Adv Musculoskelet Dis. 2012 - Apr;4(2).55-9.
2. Komm BS, Chines AA. Bazedoxifene. the evolving role of third-generation - selective estrogen-receptor modulators in the management of postmenopausal - osteoporosis. Ther Adv Musculoskelet Dis. 2012 Feb;4(1).21-34.
3. Hadji P. The evolution of selective estrogen receptor modulators in - osteoporosis therapy. Climacteric. 2012 Aug 1. [Epub ahead of print]
4. Sodero AC, Romeiro NC, da Cunha EF, de Oliveira Magalhaães U, de Alencastro - RB, Rodrigues CR, Cabral LM, Castro HC, Albuquerque MG. Application of 4D-QSAR - studies to a series of raloxifene analogs and design of potential selective - estrogen receptor modulators. Molecules. 2012 Jun 15;17(6).7415-39.
5. Simons R, Gruppen H, Bovee TF, Verbruggen MA, Vincken JP. Prenylated - isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs). - Food Funct. 2012 Aug 25;3(8).810-27. Epub 2012 Jun 11.
6. Stice JP, Mbai FN, Chen L, Knowlton AA. Rapid Activation of Nuclear Factor κB  - by 17β-Estradiol and Selective Estrogen Receptor Modulators. Pathways Mediating - Cellular Protection. Shock. 2012 Aug;38(2).128-36.
7. Shen J, Jiang J, Kuang G, Tan C, Liu G, Huang J, Tang Y. Discovery and - structure-activity analysis of selective estrogen receptor modulators via - similarity-based virtual screening. Eur J Med Chem. 2012 Aug;54.188-96. Epub 2012 - May 14.
8. Hajjo R, Setola V, Roth BL, Tropsha A. Chemocentric informatics approach to - drug discovery. identification and experimental validation of selective estrogen  - receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as - potential cognition enhancers. J Med Chem. 2012 Jun 28;55(12).5704-19. Epub 2012  - Jun 11.
9. Birkhäuser M. [Selective Estrogen Receptor Modulators (SERMs) for prevention - and treatment of postmenopausal osteoporosis]. Ther Umsch. 2012 Mar;69(3).163-72. - Review. German.
10. Birzniece V, Sutanto S, Ho KK. Gender difference in the neuroendocrine - regulation of growth hormone axis by selective estrogen receptor modulators. J - Clin Endocrinol Metab. 2012 Apr;97(4).E521-7. Epub 2012 Feb 8.
11. Velázquez-Zamora DA, Garcia-Segura LM, González-Burgos I. Effects of - selective estrogen receptor modulators on allocentric working memory performance  - and on dendritic spines in medial prefrontal cortex pyramidal neurons of - ovariectomized rats. Horm Behav. 2012 Apr;61(4).512-7. Epub 2012 Jan 21.
12. Rodrigues DM Jr, dos Santos AR, Cavalcante AA, Alencar AP, Lopes-Costa PV, da - Silva BB. Assessment of micronucleus frequency in the peripheral blood of female  - rats in persistent estrus treated with selective estrogen receptor modulators. - Environ Mol Mutagen. 2012 Jan;53(1).51-4. doi. 10.1002/em.20676. Epub 2011 Aug - 29.
13. Komm BS, Chines AA. An update on selective estrogen receptor modulators for - the prevention and treatment of osteoporosis. Maturitas. 2012 Mar;71(3).221-6. - Epub 2011 Dec 22. Review.
14. Palacios S, Brincat M, Erel CT, Gambacciani M, Lambrinoudaki I, Moen MH, - Schenck-Gustafsson K, Tremollieres F, Vujovic S, Rees M, Rozenberg S. EMAS - clinical guide. selective estrogen receptor modulators for postmenopausal - osteoporosis. Maturitas. 2012 Feb;71(2).194-8. Epub 2011 Dec 15. Review.
15. González-Burgos I, Rivera-Cervantes MC, Velázquez-Zamora DA, Feria-Velasco A, - Garcia-Segura LM. Selective estrogen receptor modulators regulate dendritic spine - plasticity in the hippocampus of male rats. Neural Plast. 2012;2012.309494. Epub  - 2011 Nov 2.
16. Therrien E, Englebienne P, Arrowsmith AG, Mendoza-Sanchez R, Corbeil CR, - Weill N, Campagna-Slater V, Moitessier N. Integrating medicinal chemistry, - organic/combinatorial chemistry, and computational chemistry for the discovery of - selective estrogen receptor modulators with Forecaster, a novel platform for drug - discovery. J Chem Inf Model. 2012 Jan 23;52(1).210-24. Epub 2011 Dec 15.
17. Calmarza-Font I, Lagunas N, Garcia-Segura LM. Antidepressive and anxiolytic - activity of selective estrogen receptor modulators in ovariectomized mice - submitted to chronic unpredictable stress. Behav Brain Res. 2012 Feb - 1;227(1).287-90. Epub 2011 Oct 29.
18. Abdelhamid R, Luo J, Vandevrede L, Kundu I, Michalsen B, Litosh VA, Schiefer  - IT, Gherezghiher T, Yao P, Qin Z, Thatcher GR. Benzothiophene Selective Estrogen  - Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism. - ACS Chem Neurosci. 2011 May 18;2(5).256-268.
19. Yadav Y, Maclean ED, Bhattacharyya A, Parmar VS, Balzarini J, Barden CJ, Too  - CK, Jha A. Design, synthesis and bioevaluation of novel candidate selective - estrogen receptor modulators. Eur J Med Chem. 2011 Sep;46(9).3858-66. Epub 2011 - May 30.
20. Mark-Kappeler CJ, Martin DS, Eyster KM. Estrogens and selective estrogen - receptor modulators regulate gene and protein expression in the mesenteric - arteries. Vascul Pharmacol. 2011 Jul-Sep;55(1-3).42-9. Epub 2011 Jun 1.
21. Lello S. [Selective estrogen receptor modulators. focus on bazedoxifene]. - Minerva Ginecol. 2011 Jun;63(3).305-14. Review. Italian. Erratum in. Minerva - Ginecol. 2011 Dec;63(6).580.
22. Palacios S. Selective estrogen receptor modulators. the future in menopausal  - treatment. Minerva Ginecol. 2011 Jun;63(3).275-86.
23. Bouchard C. Selective estrogen receptor modulators and their effects on hot - flashes. a dilemma. Menopause. 2011 May;18(5).477-9.
24. Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, - Degani H, Sussman JL. Structure of estradiol metal chelate and estrogen receptor  - complex. the basis for designing a new class of selective estrogen receptor - modulators. J Med Chem. 2011 May 26;54(10).3575-80. Epub 2011 Apr 19.
25. Baraka AM, Korish AA, Soliman GA, Kamal H. The possible role of estrogen and  - selective estrogen receptor modulators in a rat model of Parkinson's disease. - Life Sci. 2011 May 9;88(19-20).879-85. Epub 2011 Mar 21.
26. Rosano C, Stec-Martyna E, Lappano R, Maggiolini M. Structure-based approach - for the discovery of novel selective estrogen receptor modulators. Curr Med Chem. - 2011;18(8).1188-94. Review.
27. Kumar R, Verma V, Sarswat A, Maikhuri JP, Jain A, Jain RK, Sharma VL, Dalela  - D, Gupta G. Selective estrogen receptor modulators regulate stromal proliferation - in human benign prostatic hyperplasia by multiple beneficial mechanisms--action - of two new agents. Invest New Drugs. 2012 Apr;30(2).582-93. Epub 2010 Dec 23. -
28. Vogel VG. Selective estrogen receptor modulators and aromatase inhibitors for - breast cancer chemoprevention. Curr Drug Targets. 2011 Dec;12(13).1874-87. - Review.
29. Arevalo MA, Santos-Galindo M, Lagunas N, Azcoitia I, Garcia-Segura LM. - Selective estrogen receptor modulators as brain therapeutic agents. J Mol - Endocrinol. 2011 Jan 19;46(1).R1-9. Print 2011 Feb. Review.
30. Pickar JH, Mirkin S. Tissue-selective agents. selective estrogen receptor - modulators and the tissue-selective estrogen complex. Menopause Int. 2010 - Sep;16(3).121-8. Review.
31. Chen YX, Luo NS, Lin YQ, Yuan WL, Xie SL, Nie RQ, Wang JF. Selective estrogen - receptor modulators promising for cardiac syndrome X. J Postgrad Med. 2010 - Oct-Dec;56(4).328-31.
32. Birzniece V, Sata A, Sutanto S, Ho KK. Neuroendocrine regulation of growth - hormone and androgen axes by selective estrogen receptor modulators in healthy - men. J Clin Endocrinol Metab. 2010 Dec;95(12).5443-8. Epub 2010 Sep 15.
33. Silverman SL. New selective estrogen receptor modulators (SERMs) in - development. Curr Osteoporos Rep. 2010 Sep;8(3).151-3. Review.
34. Paimela T, Hyttinen JM, Viiri J, Ryhänen T, Karvonen MK, Unkila M, Uusitalo - H, Salminen A, Kaarniranta K. Influence of selective estrogen receptor modulators - on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19).  - Eur J Pharmacol. 2010 Aug 25;640(1-3).219-25. Epub 2010 May 21.
35. Castle PE. Do selective estrogen receptor modulators treat cervical precancer - and cancer? Time to pool data from relevant trials. Int J Cancer. 2011 Feb - 15;128(4).997-8. doi. 10.1002/ijc.25393.
36. Shulman LP. Selective estrogen receptor modulators and vulvovaginal atrophy.  - can we improve the lives of our patients with new therapeutic options? Menopause. - 2010 May-Jun;17(3).452-3.
37. Shahryarinejad A, Gardner TR, Cline JM, Levine WN, Bunting HA, Brodman MD, - Ascher-Walsh CJ, Scotti RJ, Vardy MD. Effect of hormone replacement and selective - estrogen receptor modulators (SERMs) on the biomechanics and biochemistry of - pelvic support ligaments in the cynomolgus monkey (Macaca fascicularis). Am J - Obstet Gynecol. 2010 May;202(5).485.e1-9.
38. Kansra S, Chen S, Bangaru ML, Sneade L, Dunckley JA, Ben-Jonathan N. - Selective estrogen receptor down-regulator and selective estrogen receptor - modulators differentially regulate lactotroph proliferation. PLoS One. 2010 Apr - 19;5(4).e10060.
39. Pinkerton JV, Goldstein SR. Endometrial safety. a key hurdle for selective - estrogen receptor modulators in development. Menopause. 2010 - May-Jun;17(3).642-53. Review.
40. de Araujo LF, Grozovsky R, dos Santos Pereira MJ, de Carvalho JJ, Vaisman M,  - Carvalho DP. Expressions of vascular endothelial growth factor and nitric oxide - synthase III in the thyroid gland of ovariectomized rats are upregulated by - estrogen and selective estrogen receptor modulators. Thyroid. 2010 - Jan;20(1).85-92.
41. Baumann CK, Castiglione-Gertsch M. Clinical use of selective estrogen - receptor modulators and down regulators with the main focus on breast cancer. - Minerva Ginecol. 2009 Dec;61(6).517-39. Review.
42. DuSell CD, Nelson ER, Wittmann BM, Fretz JA, Kazmin D, Thomas RS, Pike JW, - McDonnell DP. Regulation of aryl hydrocarbon receptor function by selective - estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1).33-46. Epub 2009 Nov - 9.
43. Okada H, Tsutsumi A, Imai M, Nakajima T, Yasuda K, Kanzaki H. Estrogen and - selective estrogen receptor modulators regulate vascular endothelial growth - factor and soluble vascular endothelial growth factor receptor 1 in human - endometrial stromal cells. Fertil Steril. 2010 May 15;93(8).2680-6. Epub 2009 Oct - 13.
44. de Villiers TJ. Clinical issues regarding cardiovascular disease and - selective estrogen receptor modulators in postmenopausal women. Climacteric. - 2009;12 Suppl 1.108-11. Review.
45. Wang T, You Q, Huang FS, Xiang H. Recent advances in selective estrogen - receptor modulators for breast cancer. Mini Rev Med Chem. 2009 - Sep;9(10).1191-201. Review.
46. Barreto G, Santos-Galindo M, Diz-Chaves Y, Pernía O, Carrero P, Azcoitia I, - Garcia-Segura LM. Selective estrogen receptor modulators decrease reactive - astrogliosis in the injured brain. effects of aging and prolonged depletion of - ovarian hormones. Endocrinology. 2009 Nov;150(11).5010-5. Epub 2009 Sep 24. -
47. Vogel VG. Altering the propensity for density. the benefits and risks of - selective estrogen receptor modulators. Menopause. 2009 Nov-Dec;16(6).1079-82. -
48. Glace L, Grygielko ET, Boyle R, Wang Q, Laping NJ, Sulpizio AC, Bray JD. - Estrogen-induced stromal cell-derived factor-1 (SDF-1/Cxcl12) expression is - repressed by progesterone and by Selective Estrogen Receptor Modulators via - estrogen receptor alpha in rat uterine cells and tissues. Steroids. 2009 - Nov-Dec;74(13-14).1015-24. Epub 2009 Aug 7.
49. Cerciat M, Unkila M, Garcia-Segura LM, Arevalo MA. Selective estrogen - receptor modulators decrease the production of interleukin-6 and - interferon-gamma-inducible protein-10 by astrocytes exposed to inflammatory - challenge in vitro. Glia. 2010 Jan 1;58(1).93-102.
50. Biersack B, Schobert R. Metallodrug Conjugates with Steroids and Selective - Estrogen Receptor Modulators (SERM). Curr Med Chem. 2009;16(18).2324-37. Review.  -
51. Peng J, Sengupta S, Jordan VC. Potential of selective estrogen receptor - modulators as treatments and preventives of breast cancer. Anticancer Agents Med  - Chem. 2009 Jun;9(5).481-99. Review.
52. Nomura H, Kawashima H, Masaki S, Hosono TY, Matsumura K, Tamada S, Tanaka T,  - Nakatani T. Effect of selective estrogen receptor modulators on cell - proliferation and estrogen receptor activities in normal human prostate stromal - and epithelial cells. Prostate Cancer Prostatic Dis. 2009;12(4).375-81. Epub 2009 - May 26.
53. DonCarlos LL, Azcoitia I, Garcia-Segura LM. Neuroprotective actions of - selective estrogen receptor modulators. Psychoneuroendocrinology. 2009 Dec;34 - Suppl 1.S113-22. Epub .
54. Nath A, Sitruk-Ware R. Pharmacology and clinical applications of selective - estrogen receptor modulators. Climacteric. 2009 Jun;12(3).188-205. Review.
55. Meczekalski B, Czyzyk A. [Selective estrogen receptor modulators in treatment - of postmenopausal osteoporosis]. Ginekol Pol. 2009 Mar;80(3).213-7. Review. - Polish.
56. Jain N, Xu J, Kanojia RM, Du F, Jian-Zhong G, Pacia E, Lai MT, Musto A, Allan - G, Reuman M, Li X, Hahn D, Cousineau M, Peng S, Ritchie D, Russell R, Lundeen S,  - Sui Z. Identification and structure-activity relationships of chromene-derived - selective estrogen receptor modulators for treatment of postmenopausal symptoms.  - J Med Chem. 2009 Dec 10;52(23).7544-69.
57. Dunn BK, Ryan A. Phase 3 trials of aromatase inhibitors for breast cancer - prevention. following in the path of the selective estrogen receptor modulators.  - Ann N Y Acad Sci. 2009 Feb;1155.141-61. Review.
58. Lo SS, Pritchard KI, Robinson P, Albain KS. Endocrine Therapy with Selective  - Estrogen Receptor Modulators (SERMs) and Aromatase Inhibitors in the Prevention - and Adjuvant Therapy Settings. Cancer Treat Res. 2009;147.1-29.
59. Martín-Santamaría S, Rodríguez JJ, de Pascual-Teresa S, Gordon S, Bengtsson - M, Garrido-Laguna I, Rubio-Viqueira B, López-Casas PP, Hidalgo M, de - Pascual-Teresa B, Ramos A. New scaffolds for the design of selective estrogen - receptor modulators. Org Biomol Chem. 2008 Oct 7;6(19).3486-96. Epub 2008 Aug 4.  -
60. Bebo BF Jr, Dehghani B, Foster S, Kurniawan A, Lopez FJ, Sherman LS. - Treatment with selective estrogen receptor modulators regulates myelin specific - T-cells and suppresses experimental autoimmune encephalomyelitis. Glia. 2009 - May;57(7).777-90.
61. Peano BJ, Crabtree JS, Komm BS, Winneker RC, Harris HA. Effects of various - selective estrogen receptor modulators with or without conjugated estrogens on - mouse mammary gland. Endocrinology. 2009 Apr;150(4).1897-903. Epub 2008 Nov 20. -
62. Yamamoto Y, Iwase H. Safety profiles of aromatase inhibitors and selective - estrogen-receptor modulators in the treatment of early breast cancer. Int J Clin  - Oncol. 2008 Oct;13(5).384-94. Epub 2008 Oct 23. Review.
63. Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, - Bolton JL, Thatcher GR. Structural modulation of oxidative metabolism in design - of improved benzothiophene selective estrogen receptor modulators. Drug Metab - Dispos. 2009 Jan;37(1).161-9. Epub 2008 Oct 20.
64. Oseni T, Patel R, Pyle J, Jordan VC. Selective estrogen receptor modulators - and phytoestrogens. Planta Med. 2008 Oct;74(13).1656-65. Epub 2008 Oct 8. Review. -
65. Harris HA, Chennathukuzhi VM, Zhang X, Mekonnen B, Jelinsky SA, Schelling SH, - Patel VS, Huselton C, Negahban A, Azam F, Winneker RC. Development of an early - biomarker for the ovarian liability of selective estrogen receptor modulators in  - rats. J Steroid Biochem Mol Biol. 2008 Nov;112(1-3).40-6. Epub 2008 Sep 4.
66. Col NF, Chlebowski RT. Risks and benefits of therapy with menopausal hormones - versus selective estrogen-receptor modulators in peri- and postmenopausal women - at increased breast cancer risk. Menopause. 2008 Jul-Aug;15(4 Suppl).804-9. - Review.
67. Saji S, Kuroi K. Application of selective estrogen receptor modulators for - breast cancer treatment according to their intrinsic nature. Breast Cancer. - 2008;15(4).262-9. Epub 2008 Jul 25. Review.
68. Ohta H. [Role of estrogen and selective estrogen receptor modulators in - anti-aging]. Clin Calcium. 2008 Jul;18(7).986-94. Review. Japanese.
69. Dai SY, Chalmers MJ, Bruning J, Bramlett KS, Osborne HE, Montrose-Rafizadeh - C, Barr RJ, Wang Y, Wang M, Burris TP, Dodge JA, Griffin PR. Prediction of the - tissue-specificity of selective estrogen receptor modulators by using a single - biochemical method. Proc Natl Acad Sci U S A. 2008 May 20;105(20).7171-6. Epub - 2008 May 12.
70. Lee WL, Cheng MH, Chao HT, Wang PH. The role of selective estrogen receptor - modulators on breast cancer. from tamoxifen to raloxifene. Taiwan J Obstet - Gynecol. 2008 Mar;47(1).24-31. Review.
71. Crabtree JS, Peano BJ, Zhang X, Komm BS, Winneker RC, Harris HA. Activity of  - three selective estrogen receptor modulators on hormone-dependent responses in - the mouse uterus and mammary gland. Mol Cell Endocrinol. 2008 Jun - 11;287(1-2).40-6. Epub 2008 Feb 12.
72. Shelly W, Draper MW, Krishnan V, Wong M, Jaffe RB. Selective estrogen - receptor modulators. an update on recent clinical findings. Obstet Gynecol Surv.  - 2008 Mar;63(3).163-81. Review.
73. Carroll JC, Pike CJ. Selective estrogen receptor modulators differentially - regulate Alzheimer-like changes in female 3xTg-AD mice. Endocrinology. 2008 - May;149(5).2607-11. Epub 2008 Feb 14.
74. Xiao A, Zhang Z, An L, Xiang Y. 3D-QSAR and docking studies of - 3-arylquinazolinethione derivatives as selective estrogen receptor modulators. J  - Mol Model. 2008 Feb;14(2).149-59. Epub 2008 Jan 3.
75. Xie L, Wang J, Bourne PE. In silico elucidation of the molecular mechanism - defining the adverse effect of selective estrogen receptor modulators. PLoS - Comput Biol. 2007 Nov;3(11).e217. Epub 2007 Sep 26.
76. Migliaccio S, Brama M, Spera G. The differential effects of bisphosphonates,  - SERMS (selective estrogen receptor modulators), and parathyroid hormone on bone - remodeling in osteoporosis. Clin Interv Aging. 2007;2(1).55-64. Review.
77. Hardman MJ, Emmerson E, Campbell L, Ashcroft GS. Selective estrogen receptor  - modulators accelerate cutaneous wound healing in ovariectomized female mice. - Endocrinology. 2008 Feb;149(2).551-7. Epub 2007 Nov 1.
78. Hamad A, Kluk M, Fox J, Park M, Turner JE. The effects of aromatase - inhibitors and selective estrogen receptor modulators on eye development in the - zebrafish (Danio rerio). Curr Eye Res. 2007 Oct;32(10).819-27.
79. Wu T, Chen X, Xie L. Selective estrogen receptor modulators (SERMs) for - uterine leiomyomas. Cochrane Database Syst Rev. 2007 Oct 17;(4).CD005287. Review. -
80. Jordan VC, O'Malley BW. Selective estrogen-receptor modulators and - antihormonal resistance in breast cancer. J Clin Oncol. 2007 Dec - 20;25(36).5815-24. Epub 2007 Sep 24. Review.
81. Mark CJ, Tatchum-Talom R, Martin DS, Eyster KM. Effects of estrogens and - selective estrogen receptor modulators on vascular reactivity in the perfused - mesenteric vascular bed. Am J Physiol Regul Integr Comp Physiol. 2007 - Nov;293(5).R1969-75. Epub 2007 Sep 19.
82. Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, - Bolton JL, Thatcher GR. Structural modulation of reactivity/activity in design of - improved benzothiophene selective estrogen receptor modulators. induction of - chemopreventive mechanisms. Mol Cancer Ther. 2007 Sep;6(9).2418-28.
83. Simsa P, Mihalyi A, Kyama CM, Mwenda JM, Fülöp V, D'Hooghe TM. Selective - estrogen-receptor modulators and aromatase inhibitors. promising new medical - therapies for endometriosis? Womens Health (Lond Engl). 2007 Sep;3(5).617-28. -
84. Papoutsi Z, Kassi E, Fokialakis N, Mitakou S, Lambrinidis G, Mikros E, - Moutsatsou P. Deoxybenzoins are novel potent selective estrogen receptor - modulators. Steroids. 2007 Sep;72(9-10).693-704. Epub 2007 Jun 13.
85. Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, - Bolton JL, Thatcher GR. Structure-activity relationships for a family of - benzothiophene selective estrogen receptor modulators including raloxifene and - arzoxifene. ChemMedChem. 2007 Oct;2(10).1520-6.
86. Verdier-Sévrain S. Effect of estrogens on skin aging and the potential role - of selective estrogen receptor modulators. Climacteric. 2007 Aug;10(4).289-97. - Review.
87. Liu H, Qin Z, Thatcher GR, Bolton JL. Uterine peroxidase-catalyzed formation  - of diquinone methides from the selective estrogen receptor modulators raloxifene  - and desmethylated arzoxifene. Chem Res Toxicol. 2007 Nov;20(11).1676-84. Epub - 2007 Jul 13.
88. Sonpavde G, Okuno N, Weiss H, Yu J, Shen SS, Younes M, Jian W, Lerner SP, - Smith CL. Efficacy of selective estrogen receptor modulators in nude mice bearing - human transitional cell carcinoma. Urology. 2007 Jun;69(6).1221-6.
89. Sheldahl LC, Marriott LK, Bryant DM, Shapiro RA, Dorsa DM. Neuroprotective - effects of estrogen and selective estrogen receptor modulators begin at the - plasma membrane. Minerva Endocrinol. 2007 Jun;32(2).87-94. Review.
90. Musa MA, Khan MO, Cooperwood JS. Medicinal chemistry and emerging strategies  - applied to the development of selective estrogen receptor modulators (SERMs). - Curr Med Chem. 2007;14(11).1249-61. Review.
91. Gennari L, Merlotti D, Valleggi F, Martini G, Nuti R. Selective estrogen - receptor modulators for postmenopausal osteoporosis. current state of - development. Drugs Aging. 2007;24(5).361-79. Review.
92. Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, - Thatcher GR. Benzothiophene selective estrogen receptor modulators with modulated - oxidative activity and receptor affinity. J Med Chem. 2007 May 31;50(11).2682-92. - Epub 2007 May 10.
93. Wu Y, Niwa K, Onogi K, Tang L, Mori H, Tamaya T. Effects of selective - estrogen receptor modulators and genistein on the expression of ERalpha/beta and  - COX-1/2 in ovarectomized mouse uteri. Eur J Gynaecol Oncol. 2007;28(2).89-94. -
94. Cano A, Hermenegildo C, Oviedo P, Tarín JJ. Selective estrogen receptor - modulators and risk for coronary heart disease. Climacteric. 2007 - Apr;10(2).97-111. Review.
95. Palacios S. The future of the new selective estrogen receptor modulators. - Menopause Int. 2007 Mar;13(1).27-34. Review.
96. Lingxia X, Taixiang W, Xiaoyan C. Selective estrogen receptor modulators - (SERMs) for uterine leiomyomas. Cochrane Database Syst Rev. 2007 Apr - 18;(2).CD005287. Review. Update in. Cochrane Database Syst Rev. - 2007;(4).CD005287.
97. Gold DT, Silverman SL. Do estrogen or selective estrogen receptor modulators  - improve quality of life for women with postmenopausal osteoporosis? Curr - Osteoporos Rep. 2007 Mar;5(1).3-7.
98. Christodoulakos GE, Lambrinoudaki IV, Botsis DC. The cardiovascular effects - of selective estrogen receptor modulators. Ann N Y Acad Sci. 2006 - Dec;1092.374-84. Review.
99. Leung KC, Brce J, Doyle N, Lee HJ, Leong GM, Sjögren K, Ho KK. Regulation of  - growth hormone signaling by selective estrogen receptor modulators occurs through - suppression of protein tyrosine phosphatases. Endocrinology. 2007 - May;148(5).2417-23. Epub 2007 Feb 1.
100. Härkönen PL, Väänänen HK. Monocyte-macrophage system as a target for - estrogen and selective estrogen receptor modulators. Ann N Y Acad Sci. 2006 - Nov;1089.218-27. Review.
101. Sikoski P, Register TC, Lees CJ, Lundeen S, Hutchison J, Brown KH, Cline JM. - Effects of two novel selective estrogen receptor modulators, raloxifene, - tamoxifen, and ethinyl estradiol on the uterus, vagina and breast in - ovariectomized cynomolgus monkeys (Macaca fascicularis). Am J Obstet Gynecol. - 2007 Jan;196(1).75.e1-7.
102. Mann V, Huber C, Kogianni G, Collins F, Noble B. The antioxidant effect of - estrogen and Selective Estrogen Receptor Modulators in the inhibition of - osteocyte apoptosis in vitro. Bone. 2007 Mar;40(3).674-84. Epub 2006 Dec 13. -
103. Cano A, Hermenegildo C, Oviedo P, Tarín JJ. The risk for cardiovascular - disease in women. from estrogens to selective estrogen receptor modulators. Front - Biosci. 2007 Jan 1;12.49-68. Review.
104. Diez-Perez A. Selective estrogen receptor modulators (SERMS). Arq Bras - Endocrinol Metabol. 2006 Aug;50(4).720-34.
105. Dahm AE, Iversen N, Birkenes B, Ree AH, Sandset PM. Estrogens, selective - estrogen receptor modulators, and a selective estrogen receptor down-regulator - inhibit endothelial production of tissue factor pathway inhibitor 1. BMC - Cardiovasc Disord. 2006 Oct 9;6.40.
106. Kozakiewicz K, Wycisk A. [Hormonal replacement therapy and selective - estrogen receptor modulators in prevention of cardiovascular disease]. Wiad Lek.  - 2006;59(5-6).377-82. Review. Polish.
107. Smith MR. Selective estrogen receptor modulators to prevent - treatment-related osteoporosis. Rev Urol. 2005;7 Suppl 3.S30-5.
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