Pharmacology Review of Everything

Pharmacology Review of Everything 2003-2004

Abacavir
Antiretroviral
Nucleoside reverse transcriptase inhibitor (NRTI)

Abciximab
Antiplatelet
Anti-GPIIb/IIIa receptor antibody

Acarbose
Oral hypoglycemic
Alpha-glucosidase inhibitor
Inhibitor of intestinal glucose absorption

Acebutolol
Sympatholytic
1 adrenergic antagonist
Class II antiarrhytmic

Antihypertensive
Antianginal
Bronchoconstrictor

Acetaminophen
Analgesic, Antipyretic

Acetazolamide
Diuretic
Carbonic anhydrase inhibitor


Acetylcholine
Cholinomimetic
Antigluacoma
Muscle contraction (nicotinic receptor)

Activated charcoal
Antidote

Acyclovir
Antiherpes
Purine analog
Phosphorylated to inhibitor of viral DNA polymerase

Adenosine
Antiarrhythmic
Miscellaneous
(does not fit class I-IV organization)

Adrenocorticotropin
(ACTH)
Anterior pituitary hormone
Anticonvulsant

Stimulates synthesis
and release of cortisol


Albendazole
Antihelminthic
Treatment of intestinal roundworms

Albuterol
Sympathomimetic
2 adrenergic agonist
Short acting bronchodilator
Used in asthma

Aldosterone
Adrenocorticosteroid
Mineralocorticoid

Alemtuzumab
Antineoplastic
Anti-CD52 antibody

Alendronate
Anti-osteoporesis

Bisphosphonate
Inhibitor of osteoclast-mediated bone resorption

Alfentanil
Opioid
General anaesthetic
Intravenous anaesthetic

Allopurinol
Antigout
Antineoplastic (supporting agent)

Folic acid analogue
Xanthine oxidase inhibitor


Alteplase
Thrombolytic
Tissue plasminogen activator (tPA)

Aluminum hydroxide
Antiulcer
Antacid

Amantadine
Antiviral
Antiparkinson

Treatment of Influenza A
Inhibits replication
at the stage of uncoating

List goes A-Z. This is very exhaustive presentation.

Pharmacology Review of Everything 2003-2004

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Designing Anti-Tumor Drugs Using Natural and Synthetic Agents

Designing Anti-Tumor Drugs Using Natural and Synthetic Agents
By:Herman L. Holt, Jr.
University of North Carolina, Asheville

Medicinal Chemistry Folklore
Famous for Synthesis and Discovery of the Mechanism of Action of:
Indomethacin
Sulindac
Diflunisal
Other anti-inflammatory-analgesic (NSAIDS) and immunoregulators
More than 210 U.S. Patents and scientific publications


* Medicinal Chemistry is defined as an interdisciplinary science situated at the interface of organic chemistry and life sciences (such as biochemistry, pharmacology, molecular biology, immunology, pharmacokinetics and toxicology) on one side and chemistry-based disciplines (such as physical chemistry, crystallography, spectroscopy and computer-based information technologies) on the other.

Chemistry based disciplines
Organic Chemistry
Life Sciences
Medicinal Chemistry
Definition and Objectives
Challenges for Medicinal Chemistry
TUBULIN
* Globular Protein
* Taxoid Site
* Vanca Alkaloid
Domain
* Colchicine Site
MICROTUBULES
* Tubulin Polymers
MITOTIC SPINDLE
* Composed of Microtubules and associated proteins
* Needed for cellular division
* Tubulin Polymers

What is the MTT assay?
CISPLATIN
* Anti-cancer agent
* Ovarian
* Testicular
* Lung
* Breast
* Cleaves DNA

TAXOL
* Anti-cancer agent
* Pacific Yew Tree
* Ovarian
* Testicular
* Lung
* Breast

VANCOMYCIN
COLCHICINE
COMBRETASTATIN
HETEROCYCLE ANALOGS OF COMBRETASTATIN
COMBRETASTATIN AND TRIAZOLE SYNTHESIS
AZIRIDINE ANALOGS OF COMBRETASTATINS
AZIRIDINE TYPE ANALOGS OF COMBRETASTATINS
MITOMYCINS
REFERENCES

Designing Anti-Tumor Drugs Using Natural and Synthetic Agents.ppt

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Pharmacology of Drugs Used to Treat Respiratory Disorders

The Pharmacology of Drugs Used to Treat Respiratory Disorders

Stuff about inverse-agonist beta-blockers (nadolol) and asthma
Asthma
COPD
Rhinitis & rhinorrhea
Cough

Asthma

“Obstruction of the airways (3rd to 7th generation of the bronchi) that is reversible with time or in response to treatment.”
Causes

* Allergens
* Cold air
* Exercise
* Upper respiratory infections
* Genetics

Features of asthma
Breathlessness
Cough
Wheezing
Chest tightness
Hyper-responsive lower airway
Hyperinflated lungs
Treatment

Remodeled airway
Poor distensibility of airway lumen on inspiration
Submucosal swelling internal to rigid zone with edema
Limited response to bronchodilator or anti-inflammatory therapy

Cells Recruited During Asthmatic Inflammation
Modulators of BSM contraction Contraction
Smooth muscle cell
Inflammatory mediators (e.g., histamine)
Goals of Therapy

Pharmacologic Therapy of Asthma
Anti-inflammatory
Bronchodilation
Prophylaxis
Anti-inflammatory Glucocorticoids
* Corticosteroids: the most effective anti-inflammatory agents.
* Primary action is to regulate gene expression.
Pharmacologic Actions
Anti-inflammatory Glucocorticoids
Inhalation of corticosteroids minimizes side effects
Disposition of Inhaled Drugs
Glucocorticoids Pharmacologic Actions
Inflammation Bronchonstriction
Mechanism of Action
Glucocorticoid Toxicity Administration by Inhalation
Toxicity: Inhalation
Glucocorticoid Toxicity: Systemic administration
Toxicity: Chronic systemic
Precautions/Contraindications
Therapy of Asthma
Long-acting(prophylaxis)
Short-acting(symptomatic)
and more topics are covered

The Pharmacology of Drugs Used to Treat Respiratory Disorders.ppt

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