Osteoarticular & Connective Tissues Systemic Pathology

Systemic Pathology

Osteoarticular & Connective Tissues
Bone
Function of Bone
Structure of Bone
Bone Remodeling Cycle
Osteoclasts
Osteoblasts
Fractures & Their Healing
Healing of Fractures
Congenital & Hereditary Bone Disorders
Achondroplasia
Osteogenesis Imperfecta
Regulation of Calcium Metabolism
Role in metabolic bone disease
Osteoporosis
Aetiological Factors
Factors in the Development of Osteoporosis
Pathogenesis
Acquired or genetic aetiology
Clinical Features
Rickets & Osteomalacia
manifestations of Vitamin D deficiency
Clinical Features & Diagnosis
Bone Disease Associated with Hyperparathyroidism & Hypercalcaemia
Morphology
Renal Osteodystrophy
Mechanisms of Renal Bone Disease
Osteomyelitis
Pathogenesis
Acute Osteomyelitis
Chronic Osteomyelitis
Tuberculous Osteomyelitis
Paget’s Disease (Osteitis Deformans)
Pathogenesis
Morphology
The affected femur shows characteristic thickening & deormity
Bone Tumours
Disease of the Joints
Osteoarthritis
Fibrillation & fissuring seen in osteoarthritis
Rheumatoid Arthritis
Immunological Abnormalities
Infectious Agents
Pathogenesis Overview
Extra-Articular Features
Spondyloarthropathies
Infective Arhtritis (Sepetic arthritis)
Aetiological Organisms

* Staphylococcus aureus
* S. albus (prosthetic jnts); S. pyogens
* Diplococcus pneumoniae
* Neisseria gonorrhoeae (STD)
* Heamophilus influenza (children)
* Gram –ve organisms (drug addicts)
* Borrelia burgdorferi (Lyme disease
* Mycobacterium TB
* Brucella abortus (intervertebral discs)

Routes of infection

* Haematogenous
* Traumatic implantation
* Direct spread from adjacent tissue

Gout
Aetiology of Hyperuricaemia
CHRONIC TOPHACEOUS ARTHRITIS
Pathogenesis of Renal Involvement
Typical Clinical Presentations
Pyrophosphate Arthropathy pseudogout
Systemic Diseases & Joint Changes
Examples

Systemic Pathology.ppt