16 July 2009

Chest Trauma



Chest Trauma
by:Kent J. Blanke, D.O., FACOS
Introduction
Thoracic Trauma
Penetrating Chest Injuries
* Majority are stab wounds or gunshot wounds (GSW)
* Lower mortality rates--less likely to include multiorgan injury
* 85% of penetrating chest wounds can be treated with tube thoracostomy and supportive measures
Penetrating Chest Trauma
* Wounds that enter or exit inferior to the nipple or the posterior tip of scapula may perforate the dome of the diaphragm.
* Any penetrating wound such as this should be considered to have an abdominal component until proven otherwise.

Penetrating Chest Trauma: Treatment
* ATLS protocol: A,B,C,D,E’s
* Emergency management
o Needle thoracentesis
o Tube thoracostomy
o Subxiphoid pericardotomy
o Video assisted thoracic surgery (VATS)

Work-up of Penetrating Chest Trauma
* Physical examination
o Look, Listen, Feel
o Contusions, diminished or absent breath sounds, SQ emphysema can readily be found
* CXR- best, least expensive and fastest initial evaluation
* Ultrasound-may soon replace CXR as initial radiographic study in chest trauma
* Angiography- to look for great vessel injuries
* CT Scan: for better evaluation of chest wall and parenchyma
* Transesophogeal Echocardiography

Penetrating Chest Injuries
* Operative intervention required for:
o Massive or persistent bleeding
o Massive air leak
o Tracheobronchial injuries
o Esophageal perforation
o Cardiac or great vessel injuries
o Post-traumatic empyema
* Wounds that enter or exit inferior to the nipple or the posterior tip of scapula may perforate the dome or the diaphragm.
* Any penetrating wound such as this should be considered to have an abdominal component until proven otherwise.

Penetrating Chest Trauma:Indications for Mechanical Ventilation
Intrapulmonary Foreign Bodies
* Bullets, fragments: indications for removal
Intrapulmonary Foreign Bodies
Pulmonary Parenchymal Laceration
High Velocity Missile Injuries
Blunt Chest Trauma
Categories of chest wall injuries
* Open pneumothorax
* Contusion and Hematoma
* Sternal fractures
* Scapular fractures
* Flail chest
* Intercostal vessel injury
Categories of Intra-thoracic Injuries
* Pulmonary
o Pneumothorax, hemothorax
o Pulmonary contusion
o Pulmonary laceration
* Vascular
o Great vessel disruption (Ao dissection, pulmonary vasculature)
* Cardiac
o Blunt Cardiac Injury, Penetrating injury

Work-up of Blunt Chest Trauma
* Physical examination
o Look, Listen, Feel
o Contusions, diminished or absent breath sounds, SQ emphysema can readily be found
* CXR- best, least expensive and fastest initial evaluation
* Ultrasound-may soon replace CXR as initial radiographic study in chest trauma
* Angiography- to look for great vessel injuries
* CT Scan: for better evaluation of chest wall and parenchyma
* Transesophogeal Echocardiography

Categories of chest wall injuries
* Contusion and hematoma

Categories of chest wall injuries
* Open pneumothorax
* Pneumothorax
Operative Intervention for Hemothorax

Read more...

Radiographic Findings in Blunt Chest Trauma



Soft Tissue Radiographic Findings in Blunt Chest Trauma
By:Jonathan Yarris MSIV

Trauma
* Trauma is the leading cause of death in patients < 40 years
* 4th leading COD overall
* 80% of trauma is due to blunt mechanisms

Blunt Chest Trauma (BCT)
* Seen in about ½ of blunt trauma cases
* ~20% of trauma deaths attributable to BCT
* Etiology: typically deceleration injury
* Radiographic evaluation should begin immediately after initial trauma team assessment

Approach to Trauma Radiographs
* Initial exclusion of life threatening injuries
* Followed by search for less critical injuries
* Life threatening Injuries:
Pneumothorax
Deep Sulcus Sign
Tension Pneumothorax
Tension PTX
Pulmonary Contusion
Laceration
Laceration with Pneumatocele
Hematoma
Pulmonary hematoma
Pneumatocele
Pulmonary Contusion with pneumatocele
Blunt Cardiac Injury (BCI)
Hemopericardium
Great Vessel Injury
Thoracic Aorta Injury
Intimal Flap with double lumen
Airway Injury

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Lung Examination: Abnormal



Lung Examination: Abnormal
By:Arcot J. Chandrasekhar, M.D.

Illustrative Pathological problems
* Consolidation
* Atelectasis
* Pleural effusion
* Pneumothorax
* Mass
* Diffuse lung disease

Steps
* General Examination
* Mediastinal position
* Chest expansion
* Lung resonance
* Breath sounds
* Adventitious sounds
* Voice transmission
* Respiratory rate
* Pattern of breathing
* Cyanosis
* Clubbing
* Weight
* Cough
* Hospital setting
* Effort of ventilation
* Shape of thorax

Respiratory Rate
* Bradypnea: rate less than 8 per minute
* Tachypnea: rate greater than 25 per minute

Pattern of Breathing
* Kussmals
* Sleep apnea
* Cheyne strokes
* Pursed lip breathing
* Orthopnoea: Short of breath in supine position, gets some relief by sitting or standing up.

Sleep apnea syndrome
Central Cyanosis
Corpulmonale
Clubbing
Significance: Clubbing Observed In:
* Intrathoracic malignancy: Primary or secondary (lung, pleural, mediastinal)
* Suppurative lung disease: (lung abscess, bronchiectasis, empyema)
* Diffuse interstitial fibrosis: Alveolar capillary block syndrome
* In association with other systemic disorders
Effort of Ventilation

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Thoracic Trauma



Thoracic Trauma

Dave Lloyd, MD
Introduction to Thoracic Injury
* Vital Structures
* 25% of MVC deaths are due to thoracic trauma
* Abdominal injuries are common with chest trauma.
* Prevention Focus

Anatomy and Physiology of the Thorax
* Thoracic Skeleton
* Diaphragm
* Associated Musculature
* Physiology of Respiration
* Trachea, Bronchi & Lungs
* Mediastinum
* Heart
* Contraction Cycle
* Great Vessels
* Esophagus
* Blunt Trauma
* Penetrating Trauma
Pathophysiology of Thoracic Trauma
Injuries Associated with Penetrating Thoracic Trauma
* Closed pneumothorax
* Open pneumothorax (including sucking chest wound)
* Tension pneumothorax
* Pneumomediastinum
* Hemothorax
* Hemopneumothorax
* Laceration of vascular structures
* Tracheobronchial tree lacerations
* Esophageal lacerations
* Penetrating cardiac injuries
* Pericardial tamponade
* Spinal cord injuries
* Diaphragm trauma
* Intra-abdominal penetration with associated organ injury

Pathophysiology of Thoracic Trauma Chest Wall Injuries
* Contusion
* Rib Fractures
* Sternal Fracture & Dislocation
* Flail Chest
* Simple Pneumothorax
* Open Pneumothorax
* Tension Pneumothorax
* Dyspnea
* Progressive ventilation/perfusion mismatch
* Hypoxemia
* Hyperinflation of injured side of chest
* Hyperresonance of injured side of chest
* Diminished then absent breath sounds on injured side
* Cyanosis
* Diaphoresis
* AMS
* JVD

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Artificial Airways



Artificial Airways

Definition
* A tube or tube-like device that is inserted through the nose, mouth, or into the trachea to provide an opening for ventilation

Types of Artificial Airways
* Oropharyngeal airways
* Nasopharyngeal tubes
* Orotracheal tubes
* Nasotracheal tubes
* Tracheostomy tubes
* Esophageal obturator airway
* Cricothyroid tubes

Indications for Artificial Airways
* Relief of airway obstruction -guarantees the patency of upper airway regardless of soft tissue obstruction.
* Protecting or maintaining an airway N. have 4 main airway protect. reflexes 1. Pharyngeal reflex - 9th & 10th cranial nerves gag and swallowing
* Reflexes (cont’d) 2.Laryngeal -vagovagal reflex - will cause laryngospasm 3.Tracheal -vagovagal reflex - cough when a foreign body or irritation in trachea 4.Carinal -cough with irritation of carina
* Facilitation of tracheobronchial clearance
- mobilization of secretions from the trachea requires either an adequate cough or direct suctioning of the trachea
* Facilitation of artificial ventilation
- ventilation with a mask should on be used for short periods d/t gastric insufflation

Hazards of Artificial Airways
* Infection d/t bypassing the normal defense mechanisms that prevent bacterial contamination
* Ineffective cough maneuver
* Impaired verbal communication
* Loss of personal dignity

Oropharyngeal Airway
* Device designed for insertion along the tongue until the teeth &/or gingiva limit the insertion
* Lies between the posterior pharynx and the tongue and pushes the tongue forward
* Will activate the gag reflex, should use on unconscious patient
* Correct sizing of airway is imperative

Hazards of Oropharyngeal Airway
* If too small, may not displace tongue or may cause tongue to obstruct airway or may aspirated
* It too large, may cause epiglottis impaction
* Roof of mouth may be lacerated upon insertion
* Aspiration from intact gag reflex

Nasopharyngeal Airway
* Located so that it can provide a clear path for gas flow into the pharynx
* Is a soft rubber catheter
* Can be tolerated by the conscious patient
* Useful for patient with a soft tissue obstruction who have jaw injury or spasm of jaw muscles
* Proper sizing and insertion

Orotracheal Airway

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Thoracic Trauma



Thoracic Trauma
By:EMS Professions
Temple College

Thoracic Trauma
* Second leading cause of trauma deaths after head injury
* Cause of about 10-20% of all trauma deaths
* Many deaths due to thoracic trauma are preventable
* Prevention Strategies
* Mechanisms of Injury
* Anatomical Injuries


What structures may be involved with each injury?
* Often result in:
o Hypoxia
o Hypercarbia
o Acidosis
* Ventilation & Respiration Review
* General Pathophysiology
* Initial exam directed toward life threatening:
o Injuries
o Conditions
* Assessment Findings

Specific Injuries

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Nervous system in the abdomen and pelvis



Nervous system in the abdomen and pelvis

Targets of NS in abdomen and pelvis
Abdominal muscles (motor)
Body wall & parietal peritoneum (sensory)
Perineal muscles (motor)
(eg. external anal sphincter)
Perineal skin (sensory)
Sweat glands, erector pilae & sm mm of BVs in abdominal and perineal skin
Foregut smooth muscle & glands
Midgut smooth muscle & glands
Kidneys and suprarenal glands
Hindgut smooth muscle & glands
Blood vessels of GIT
Pelvic viscera and blood vessels
Smooth muscle & glands of reproductive tract
Blood vessels in erectile tissue

SYMPATHETIC
Gray rami of chain
ganglia
Thoracic
splanchnic nerves:
Lumbar splanchnic nerves
Sacral splanchnic Nerves
Prevertebral ganglia


PARA-SYMPATHETIC
Vagus
Pelvic splanchnic nerves
Intramural ganglia/enteric nervous system
SOMATIC
Abdomino-inercostal nerves
L1 spinal nerve
Pudendal nerve
ANS in the abdomen and pelvis:
important principles
Autonomic nerves are found in plexuses along the blood vessels or other major structures
In thorax:
In abdomen:
In pelvis:
Prevertebral plexus for abdominal viscera
Several parts: named for adjacent vessel or region

Lecture Plan
* Parasympathetic innervation of GIT and other structures
* Sympathetic innervation of GIT and other structures
* Referred pain
* Somatic nerves of the abdomen, pelvis and perineum
* Sympathetic
* Parasympathetic
ANS Divisions
Parasympathetic division
Intramural neurons are part of the enteric nervous system:
Parasympathetic Vagal trunk dissection
Left and right vagus nerves
Anterior (left) and posterior (right)
vagal trunks

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Fetal outcomes: Comparison of gestational diabetes



Fetal outcomes: Comparison of oral agents with diet controlled and insulin controlled gestational diabetes
By:Amanda Hatton, MD
Investigators
* Amanda Hatton, MD
* Selman Welt, MD
* Samuel Prien, PhD

Background
* Gestational diabetes affects from 1-14% of pregnant mothers1
* Levels of diabetogenic placental steroids and peptide hormones (estrogen, progesterone, chorionic sommatomammotrophin) rise linearly throughout the second and third trimester resulting in progressively increasing tissue resistance to insulin2
* Maternal insulin resistance requires a significant increase in pancreatic insulin production to more than twice non-pregnant levels
* Failure to adequately compensate for increased demand of insulin production leads to maternal hyperglycemia followed by fetal hyperglycemia

Fetal health implications
* Fetal hyperglycemia leads to fetal hyperinsulinemia which has detrimental consequences to fetal growth and well-being2
* Promotes storage of excess nutrients leading to macrosomia
* Drives catabolism of oversupply of fuel, using energy and depleting fetal oxygen stores
* Episodic fetal hypoxia leads to increased adrenal catecholamines causing hypertension, cardiac remodeling, and hypertrophy
* Hypoxia also causes stimulation of erythropoietin which in turn increases hematocrit level and causes poor circulation and postnatal hyperbilirubinemia
* At birth fetal hyperinsulinemia in absence of maternal glucose supply leads to hypoglycemia

Treatment of GDM
* Glycemic monitoring, dietary regulation and medical therapy are used to control diabetes and prevent postnatal sequelae
* Insulin discovered in 1922, successful management of diabetic pregnancies became possible and the frequency of antepartum fetal death decreased by one half2
* Glycemic control must be instituted early and aggressively if excellent newborn outcome is to be achieved
* Oral agents such as acarbose and glyburide are aimed at augmenting insulin supply, decreasing insulin resistance, and limiting postprandial hypoglycemia
* These agents have been shown to be an effective and safe alternative, since they do not significantly cross the placenta in vitro3

Objectives
* To compare fetal outcomes in mothers with gestational diabetes treated with:
* Diet - ADA diet, weight dependent, 3 meals and 3 snacks
* Oral agents
* Acarbose - alpha-glucosidase inhibitor, reversibly inhibits enzymes in the small intestine, delaying cleavage of oligosaccharides and disaccharides to monosaccharides
* Glyburide - sulfonylurea compound, stimulates insulin release from the pancreatic beta cells, reduces glucose output from the liver and also increases insulin sensitivity at peripheral target sites
* Insulin – weight based split mix dose of NPH and Novolog, insulin pump therapy, or long acting insulin with supplementation
* This study was submitted to the IRB and was found to be exempt from formal IRB review

Experimental Design

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Ultrasonographic features of endometrium



Ultrasonographic features of endometrium in pre- and postmenopausal women
By:C. Tracy Suit, MD
Cornelia de Riese, MD
Samuel Prien, PhD
Kelsey Kelso, BS

Background

* The endometrium is a dynamic tissue
o Menstrual cycle
o Postmenopausal
o Exogenous hormones

Transvaginal US
* Non-invasive
* Relatively inexpensive
* Good safety profile
* Readily available

Normal endometrium
* Menstrual phase
* Proliferative phase
* Secretory phase
* In the follicular phase, the endometrium becomes relatively hypodense
* As the cycle progresses the endometrium becomes more hyperechoic
* Ovulatory period = trilaminar endometrium
* Usually disappears 48 hours after ovulation
* Postmenopausal women
* A small amount of fluid may be considered normal

Premenopausal—Differential Diagnosis
* Often due to normal proliferation under hormonal influences
* Can include:
o Polyps
o Polypoid growths
o Hyperplasia or cancer
o Submucosal fibroids
Postmenopausal
* Important distinction: symptoms
* Exogenous hormones
Postmenopausal—differential diagnosis
* Polyps
* Hyperplasia or cancer
* Fibroids
Associated sonographic findings
* Polyps: cystic spaces
* Hyperplasia: regular/homogeneous echotexture
* Cancer: irregular margins, indistinct borders between the endometrium and myometrium, heterogeneous echotexture, complex fluid

Study objective
* To evaluate the predictive value of endometrial thickness and descriptive sonographic appearance on pathology in pre- and postmenopausal women
Methods
* 1903 gynecologic ultrasounds of the endometrium were performed between January, 2004 and January 2009
* Stratification: Of these, 367 had pathology performed within 3 months of the ultrasound
* The patients were then divided into either pre- or post menopausal after review of the chart
* Each US was critically evaluated for:
o Endometrial thickness
o Descriptors of the endometrium

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General Internal Medicine Lectures



General Internal Medicine Lectures in ppt format from
Texas Tech University Health Sciences Centre School of Medicine

15 July 2009

Physiology Presentations



Physiology Presentations from ksums.net

Properties of Cardiac Muscle.ppt

Endo Introduction.ppt

Renal Physiology.pdf

Male Reproductive System.pdf

Endo Thyroid gland.pdf

Female Reproductive System.pdf

Respiratory physiology.ppt

Acid Base Regulation.ppt

Acid Base Regulation Modified.ppt

Acid Base Abnormality

Parathyroid Gland%20& Calcium Homeostasis.ppt

Pregnancy and Lactation.ppt

Read more...

12 July 2009

Males Embriology Presentations - Part-2



Males Embriology Powerpoint Presentations from ksums.net


Development of respiratory system

Pharyngeal Arches Pouches and Clefts Part-2

Tongue Thyroid.ppt

Face,nose, palate dev.ppt

Body cavities.ppt

Digestive system.ppt Part-2

Dev. Urinary System.ppt

Read more...

Males Embriology Presentations - Part-1



Males Embriology Powerpoint Presentations from ksums.net

Gametogenesis.ppt

Ovarian & Uterine Cycles.ppt

Fertilization.ppt

Implantation.ppt

Bilaminar & Trilaminar Discs.ppt

Ectoderm Derivatives.ppt

Ectoderm Derivatives.pdf

Read more...

Female Embriology Presentations - Part-2



Female Embriology Powerpoint Presentations from ksums.net


Pharyngeal arches.ppt


Development of face.ppt

Body cavities Primitive Mesenteries and Diaphragm.ppt

Foregut Derivatives.ppt


Midgut & Hindgut Embryo.ppt

Urinary Embrio.ppt

Male genital system.ppt

Read more...

Female Embriology Presentations - Part-1



Female Embriology Powerpoint Presentations from ksums.net

Gametogenesis.ppt

Ovarian and Uterine Cycles.ppt

Fertilization.ppt

Implantation.ppt

Bilaminar & Trilaminar Embryonic Disc.ppt

Ectodermal Derivitives.ppt

Read more...
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