Viral Hepatitis Medicine Student Lecture

Viral Hepatitis Medicine Student Lecture
Presentation by:David R Nelson, M.D.

Associate Professor of Medicine
Director, Hepatology and Liver Transplantation
University of Florida

Causes of Acute Hepatitis

Acute Hepatitis
Viral Hepatitis
A, B/D, C, E
EBV
CMV & HSV
Drugs
Ethanol
Tylenol
Halothane
Toxins
Jamaica Bush Tea
Mushrooms
Vascular
Hypotension
Budd-Chiari
Autoimmune
Hepatitis
Metabolic
Wilson's Disease
A1AT

Causes of Chronic Hepatitis
Chronic Hepatitis
Viral Hepatitis
Drugs
MTX
INH
Amiodarone
Alcohol
NAFLD
Autoimmune
AIH
PBC
PSC
Metabolic
A1AT
HHC

Hepatitis A Virus
Nucleic Acid: 7.5 kb ssRNA
HAV Prevalence
Global Prevalence of Hepatitis A Infection
Hepatitis A Prevention - Immune Globulin

ACIP Recommendations MMWR 1999; 48(RR12):1
Hepatitis A: Pre-exposure Vaccination
Persons at increased risk or danger of infection
Hepatitis E

Clinical Characteristics
Hepatitis B Virus
HBsAg
HBV DNA
HBcAg
HBV Sources of Infection
Signs and Symptoms of Acute Hepatitis B

Hepatitis B - Clinical Features
Progression to Chronic Hepatitis B Virus Infection
Typical Serologic Course
Recovery from acute hepatitis B
Chronic HBeAg + disease
Chronic HBeAG – disease
Successful Vaccination
Resistance to antiviral agents
Hepatitis B: Disease Progression
Acute Infection
Chronic HBV is the 6th leading cause of liver transplantation in the US
Higher in HIV, immune suppressed
Targeted Surveillance for HCC
Hepatitis B Carriers
Non-hepatitis B Cirrhosis
Prevention of Transmission of Hepatitis B

and much more are discussed in this presentation.
Viral Hepatitis Medicine Student Lecture.ppt