Routes of Drug Administration

Routes of Drug Administration
By:Robert L. Copeland, Ph.D.
Department of Pharmacology, Howard University

Drug Absorption

* Absorption is the process by which a drug enters the bloodstream without being chemically altered or
* The movement of a drug from its site of application into the blood or lymphatic system
* Factors which influence the rate of absorption
* The rate at which a drug reaches it site of action depends on:
* Mechanisms of solute transport across membranes
Ion Trapping:
Kidney:
Lipid-Water Partition Coefficient
Enteral Routes
Sublingual/Buccal
Oral
First-pass Effect
Parenteral Routes
Intravascular
Absorption phase is bypassed
Intramuscular
Subcutaneous
Inhalation
Topical
Time-release preparations

Routes of Drug Administration.ppt