Chronic Kidney Disease

Chronic Kidney Disease
By:Justin A. Glass, MD
Emory Family Medicine

Objectives
* CKD o Definition
o Epidemiology
o Management

Literature sources
Normal Kidney Function
* Regulation of fluid / electrolyte balance
* Regulation of blood pressure
* Regulation of red cell mass
* Regulation of calcium / phosphate metabolism
* Renal hormones
o Renin
o Bradykinin
o Prostaglandins (PGE2 / PGI2)
o Erythropoietin
o Calcitriol

Definition of CKD
* Chronic Kidney Disease (CKD)
* Kidney Damage
o Proteinuria
o Abnormal urine sediment
o Abnormal serum or urine chemistries
o Abnormal imaging study

Proteinuria
Abnormal Sediment
Definition: Chronic Kidney Disease
Renal Function Measurement
Classification of CKD
* Stage 0: At risk patients
* Stage 1: Kidney damage w/ normal GFR
* Stage 2: GFR 60-89
* Stage 3: GFR 30-59
* Stage 4: GFR 15-29
* Stage 5: GFR <15 or dialysis
CKD: Burden of disease
* Definitions (expanded)
Risk Factor Modification
CKD: Cause
Prevention of progression
Complications of CKD
Anemia due to CKD
Anemia in CKD
Anemia in CKD: Treatment
Bone Disease in CKD
Hypertension in CKD
Cardiovascular Disease in CKD
CVD Prevention in CKD
When to refer?

Chronic Kidney Disease.ppt